Randomised double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal

This study compares the clinical response to lofexidine and clonidine in the out-patient treatment of opiate withdrawal in 50 opiate addicts, using a randomised double-blind study design. Patients were taking 40 mg or less methadone daily, or equivalent amounts of other opiates. Fifty-eight percent...

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Veröffentlicht in:	Drug and alcohol dependence 1998-05, Vol.50 (3), p.251-254
Hauptverfasser:	Carnwath, Tom, Hardman, Jo-anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - adverse effects Adrenergic alpha-Agonists - therapeutic use Adult Ambulatory Care - methods Ambulatory detoxification Biological and medical sciences Blood Pressure - drug effects Chi-Square Distribution Clonidine Clonidine - adverse effects Clonidine - analogs & derivatives Clonidine - therapeutic use Double-Blind Method Drug addictions Drug addicts Drug Therapy, Combination Female Humans Lofexidine Male Medical sciences Methadone - therapeutic use Narcotic Antagonists - adverse effects Narcotic Antagonists - therapeutic use Narcotics - therapeutic use Opiate withdrawal Opiates Opioid-Related Disorders - drug therapy Opioid-Related Disorders - rehabilitation Severity of Illness Index Substance Withdrawal Syndrome - drug therapy Time Factors Toxicology Treatment Treatment Outcome Withdrawal symptoms
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