One-year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment
Aim. To evaluate outcomes 1 year after cessation of treatment for cocaine‐ and alcohol‐dependent individuals. Design. Randomized controlled trial. Setting. Urban substance abuse treatment center. Participants. Ninety‐six of 122 subjects randomized to treatment. Interventions. One of five treatments...
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| Veröffentlicht in: | Addiction (Abingdon, England) England), 2000-09, Vol.95 (9), p.1335-1349 |
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| creator | Carroll, Kathleen M. Nich, Charla Ball, Samuel A. McCance, Elinore Frankforter, Tami L. Rounsaville, Bruce J. |
| description | Aim. To evaluate outcomes 1 year after cessation of treatment for cocaine‐ and alcohol‐dependent individuals.
Design. Randomized controlled trial.
Setting. Urban substance abuse treatment center.
Participants. Ninety‐six of 122 subjects randomized to treatment.
Interventions. One of five treatments delivered over 12 weeks. Cognitive‐behavioral treatment (CBT) plus disulfiram; Twelve‐Step facilitation (TSF) plus disulfiram; clinical management (CM) plus disulfiram; CBT without disulfiram; TSF without disulfiram.
Measurements. Percentage of days of cocaine and alcohol use during follow‐up, verified by urine toxicology screens and breathalyzer tests.
Results. First, as a group, participants reported significant decreases in frequency of cocaine, but not alcohol, use after the end of treatment. Secondly, the main effects of disulfiram on cocaine and alcohol use were sustained during follow‐up. Finally, initiation of abstinence for even brief periods of time within treatment was associated with significantly better outcome during follow‐up.
Conclusions. These findings support the efficacy of disulfiram with this challenging population and suggest that comparatively brief treatments that facilitate the initiation of abstinence may have long‐term benefits. |
| doi_str_mv | 10.1046/j.1360-0443.2000.95913355.x |
| format | Article |
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Design. Randomized controlled trial.
Setting. Urban substance abuse treatment center.
Participants. Ninety‐six of 122 subjects randomized to treatment.
Interventions. One of five treatments delivered over 12 weeks. Cognitive‐behavioral treatment (CBT) plus disulfiram; Twelve‐Step facilitation (TSF) plus disulfiram; clinical management (CM) plus disulfiram; CBT without disulfiram; TSF without disulfiram.
Measurements. Percentage of days of cocaine and alcohol use during follow‐up, verified by urine toxicology screens and breathalyzer tests.
Results. First, as a group, participants reported significant decreases in frequency of cocaine, but not alcohol, use after the end of treatment. Secondly, the main effects of disulfiram on cocaine and alcohol use were sustained during follow‐up. Finally, initiation of abstinence for even brief periods of time within treatment was associated with significantly better outcome during follow‐up.
Conclusions. These findings support the efficacy of disulfiram with this challenging population and suggest that comparatively brief treatments that facilitate the initiation of abstinence may have long‐term benefits.</description><identifier>ISSN: 0965-2140</identifier><identifier>EISSN: 1360-0443</identifier><identifier>DOI: 10.1046/j.1360-0443.2000.95913355.x</identifier><identifier>PMID: 11048353</identifier><identifier>CODEN: ADICE5</identifier><language>eng</language><publisher>Oxford, UK: Carfax Publishing, part of the Taylor & Francis Group</publisher><subject>Addiction ; Adult ; Alcohol ; Alcohol dependence ; Alcohol Deterrents - therapeutic use ; Alcoholism ; Alcoholism - complications ; Alcoholism - therapy ; Biological and medical sciences ; Cocaine ; Cocaine-Related Disorders - complications ; Cocaine-Related Disorders - therapy ; Cognitive Therapy ; Combined Modality Therapy ; Dependency rehabilitation ; Disulfiram ; Disulfiram - therapeutic use ; Drug abuse ; Drug abusers ; Drug addiction ; Drug addictions ; Female ; Follow-Up Studies ; Followup studies ; Humans ; Male ; Medical sciences ; Medical treatment ; Psychology ; Psychotherapy ; Psychotherapy - methods ; Substance abuse treatment ; Temperance ; Toxicology ; Treatment ; Treatment Outcome ; U.S.A</subject><ispartof>Addiction (Abingdon, England), 2000-09, Vol.95 (9), p.1335-1349</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Carfax Publishing Company Sep 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5995-cca03e5df39c85bae8cbbf6acc1b8357b20be516cb8ede5e9b199f4df5b8398b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1360-0443.2000.95913355.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1360-0443.2000.95913355.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,31009,45583,45584</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=842128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11048353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carroll, Kathleen M.</creatorcontrib><creatorcontrib>Nich, Charla</creatorcontrib><creatorcontrib>Ball, Samuel A.</creatorcontrib><creatorcontrib>McCance, Elinore</creatorcontrib><creatorcontrib>Frankforter, Tami L.</creatorcontrib><creatorcontrib>Rounsaville, Bruce J.</creatorcontrib><title>One-year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment</title><title>Addiction (Abingdon, England)</title><addtitle>Addiction</addtitle><description>Aim. To evaluate outcomes 1 year after cessation of treatment for cocaine‐ and alcohol‐dependent individuals.
Design. Randomized controlled trial.
Setting. Urban substance abuse treatment center.
Participants. Ninety‐six of 122 subjects randomized to treatment.
Interventions. One of five treatments delivered over 12 weeks. Cognitive‐behavioral treatment (CBT) plus disulfiram; Twelve‐Step facilitation (TSF) plus disulfiram; clinical management (CM) plus disulfiram; CBT without disulfiram; TSF without disulfiram.
Measurements. Percentage of days of cocaine and alcohol use during follow‐up, verified by urine toxicology screens and breathalyzer tests.
Results. First, as a group, participants reported significant decreases in frequency of cocaine, but not alcohol, use after the end of treatment. Secondly, the main effects of disulfiram on cocaine and alcohol use were sustained during follow‐up. Finally, initiation of abstinence for even brief periods of time within treatment was associated with significantly better outcome during follow‐up.
Conclusions. These findings support the efficacy of disulfiram with this challenging population and suggest that comparatively brief treatments that facilitate the initiation of abstinence may have long‐term benefits.</description><subject>Addiction</subject><subject>Adult</subject><subject>Alcohol</subject><subject>Alcohol dependence</subject><subject>Alcohol Deterrents - therapeutic use</subject><subject>Alcoholism</subject><subject>Alcoholism - complications</subject><subject>Alcoholism - therapy</subject><subject>Biological and medical sciences</subject><subject>Cocaine</subject><subject>Cocaine-Related Disorders - complications</subject><subject>Cocaine-Related Disorders - therapy</subject><subject>Cognitive Therapy</subject><subject>Combined Modality Therapy</subject><subject>Dependency rehabilitation</subject><subject>Disulfiram</subject><subject>Disulfiram - therapeutic use</subject><subject>Drug abuse</subject><subject>Drug abusers</subject><subject>Drug addiction</subject><subject>Drug addictions</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Followup studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Psychology</subject><subject>Psychotherapy</subject><subject>Psychotherapy - methods</subject><subject>Substance abuse treatment</subject><subject>Temperance</subject><subject>Toxicology</subject><subject>Treatment</subject><subject>Treatment Outcome</subject><subject>U.S.A</subject><issn>0965-2140</issn><issn>1360-0443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>7QJ</sourceid><recordid>eNqVkVGL1DAUhYso7rj6F6S44Ftr0jRpok_LjjsrDC6C4mNI0xumY9rUpGWn_96UmR1hX8SnkNzvnHvCSZIrjHKMSvZhn2PCUIbKkuQFQigXVGBCKM0Pz5LVefY8WSHBaFbgEl0kr0LYR7bionyZXOBoxAklq8Te95DNoHxqnLXuIZuG1Jm0acNkTetVl6q-SYcw650bd-DVMEfSp9pp1UapstrtnE2nAD58TMMUxuW9ScEY0GNYzEYPauygH18nL4yyAd6czsvkx-3n7zd32fZ-8-XmeptpKgTNtFaIAG0MEZrTWgHXdW2Y0hrXMXVVF6gGipmuOTRAQdRYCFM2hsax4DW5TN4ffQfvfk8QRtm1QYO1qgc3BUmrsmAFw_8ECRdEVBxF8N0TcO8m38dPyLibVaykPEKfjpD2LgQPRg6-7ZSfJUZyqU7u5VKPXOqRS3XysTp5iOq3pxVT3UHzV3vqKgJXJ0AFrazxqtdtOHO8LHCxhFgfqYfWwvw_CeT1ev14izbZ0aYNIxzONsr_kqwiFZU_v26k-LalbLNm8o78AWzBxrE</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>Carroll, 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Therapy</topic><topic>Dependency rehabilitation</topic><topic>Disulfiram</topic><topic>Disulfiram - therapeutic use</topic><topic>Drug abuse</topic><topic>Drug abusers</topic><topic>Drug addiction</topic><topic>Drug addictions</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Followup studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Psychology</topic><topic>Psychotherapy</topic><topic>Psychotherapy - methods</topic><topic>Substance abuse treatment</topic><topic>Temperance</topic><topic>Toxicology</topic><topic>Treatment</topic><topic>Treatment Outcome</topic><topic>U.S.A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carroll, Kathleen M.</creatorcontrib><creatorcontrib>Nich, Charla</creatorcontrib><creatorcontrib>Ball, Samuel A.</creatorcontrib><creatorcontrib>McCance, Elinore</creatorcontrib><creatorcontrib>Frankforter, Tami 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Abstracts (ASSIA)</collection><jtitle>Addiction (Abingdon, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carroll, Kathleen M.</au><au>Nich, Charla</au><au>Ball, Samuel A.</au><au>McCance, Elinore</au><au>Frankforter, Tami L.</au><au>Rounsaville, Bruce J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment</atitle><jtitle>Addiction (Abingdon, England)</jtitle><addtitle>Addiction</addtitle><date>2000-09</date><risdate>2000</risdate><volume>95</volume><issue>9</issue><spage>1335</spage><epage>1349</epage><pages>1335-1349</pages><issn>0965-2140</issn><eissn>1360-0443</eissn><coden>ADICE5</coden><abstract>Aim. To evaluate outcomes 1 year after cessation of treatment for cocaine‐ and alcohol‐dependent individuals.
Design. Randomized controlled trial.
Setting. Urban substance abuse treatment center.
Participants. Ninety‐six of 122 subjects randomized to treatment.
Interventions. One of five treatments delivered over 12 weeks. Cognitive‐behavioral treatment (CBT) plus disulfiram; Twelve‐Step facilitation (TSF) plus disulfiram; clinical management (CM) plus disulfiram; CBT without disulfiram; TSF without disulfiram.
Measurements. Percentage of days of cocaine and alcohol use during follow‐up, verified by urine toxicology screens and breathalyzer tests.
Results. First, as a group, participants reported significant decreases in frequency of cocaine, but not alcohol, use after the end of treatment. Secondly, the main effects of disulfiram on cocaine and alcohol use were sustained during follow‐up. Finally, initiation of abstinence for even brief periods of time within treatment was associated with significantly better outcome during follow‐up.
Conclusions. These findings support the efficacy of disulfiram with this challenging population and suggest that comparatively brief treatments that facilitate the initiation of abstinence may have long‐term benefits.</abstract><cop>Oxford, UK</cop><pub>Carfax Publishing, part of the Taylor & Francis Group</pub><pmid>11048353</pmid><doi>10.1046/j.1360-0443.2000.95913355.x</doi><tpages>15</tpages></addata></record> |
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| ispartof | Addiction (Abingdon, England), 2000-09, Vol.95 (9), p.1335-1349 |
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| language | eng |
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| source | Access via Wiley Online Library; Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE |
| subjects | Addiction Adult Alcohol Alcohol dependence Alcohol Deterrents - therapeutic use Alcoholism Alcoholism - complications Alcoholism - therapy Biological and medical sciences Cocaine Cocaine-Related Disorders - complications Cocaine-Related Disorders - therapy Cognitive Therapy Combined Modality Therapy Dependency rehabilitation Disulfiram Disulfiram - therapeutic use Drug abuse Drug abusers Drug addiction Drug addictions Female Follow-Up Studies Followup studies Humans Male Medical sciences Medical treatment Psychology Psychotherapy Psychotherapy - methods Substance abuse treatment Temperance Toxicology Treatment Treatment Outcome U.S.A |
| title | One-year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment |
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