Analysis of drug–drug interactions (DDIs) in nursing homes in Central Taiwan
Abstract With the progressive aging of the population, the long-term nursing care and drug safety for the elderly are gradually gaining attention. In Taiwan, nursing homes are the main institutes helping society or families take care of elderly people suffering from diseases. The aim of this study w...
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| Veröffentlicht in: | Archives of gerontology and geriatrics 2008-07, Vol.47 (1), p.99-107 |
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| container_title | Archives of gerontology and geriatrics |
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| creator | Liao, Hui-Ling Chen, Jin-Tang Ma, Tso-Chiang Chang, Yuan-Shiun |
| description | Abstract With the progressive aging of the population, the long-term nursing care and drug safety for the elderly are gradually gaining attention. In Taiwan, nursing homes are the main institutes helping society or families take care of elderly people suffering from diseases. The aim of this study was to assess the prescribed medications of nursing home residents, the occurrence of DDIs and the association between the number of drugs and DDIs with a view to reinforce drug safety for the elderly. The findings of this study showed that the mean number of medications per resident was 5.74 ± 2.4. Of the 323 samples, 81 (25.1%) had experienced DDIs, 63 (64.95%) were of moderate and 7 (7.2%) of major severity. The findings also showed that the number of potential DDIs increased as the number of medications used per residents increased. The residents with nine or more medications tended to have more DDIs, in comparison to those with one or two medications. The odds ratio (OR) was 11.389, which had reached statistical significance in difference. Therefore, to reduce potential DDIs, the number of medications for the senior people with chronic diseases should be properly controlled. |
| doi_str_mv | 10.1016/j.archger.2007.06.007 |
| format | Article |
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In Taiwan, nursing homes are the main institutes helping society or families take care of elderly people suffering from diseases. The aim of this study was to assess the prescribed medications of nursing home residents, the occurrence of DDIs and the association between the number of drugs and DDIs with a view to reinforce drug safety for the elderly. The findings of this study showed that the mean number of medications per resident was 5.74 ± 2.4. Of the 323 samples, 81 (25.1%) had experienced DDIs, 63 (64.95%) were of moderate and 7 (7.2%) of major severity. The findings also showed that the number of potential DDIs increased as the number of medications used per residents increased. The residents with nine or more medications tended to have more DDIs, in comparison to those with one or two medications. The odds ratio (OR) was 11.389, which had reached statistical significance in difference. Therefore, to reduce potential DDIs, the number of medications for the senior people with chronic diseases should be properly controlled.</description><identifier>ISSN: 0167-4943</identifier><identifier>EISSN: 1872-6976</identifier><identifier>DOI: 10.1016/j.archger.2007.06.007</identifier><identifier>PMID: 17868936</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Drug Interactions ; Drug Prescriptions - statistics & numerical data ; Drug safety ; Drug-Related Side Effects and Adverse Reactions - epidemiology ; Drugs ; Drug–drug interactions (DDIs) ; Elderly people ; Female ; Humans ; Incidence ; Internal Medicine ; Male ; Medication Errors - statistics & numerical data ; Middle Aged ; Nursing home ; Nursing homes ; Nursing Homes - statistics & numerical data ; Prescriptions ; Retrospective Studies ; Safety ; Taiwan ; Taiwan - epidemiology</subject><ispartof>Archives of gerontology and geriatrics, 2008-07, Vol.47 (1), p.99-107</ispartof><rights>2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-e448ff22c5b69b27b873477f588215b9ec6ab59960e46b3800fa47fea88f19c63</citedby><cites>FETCH-LOGICAL-c546t-e448ff22c5b69b27b873477f588215b9ec6ab59960e46b3800fa47fea88f19c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167494307001483$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17868936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Hui-Ling</creatorcontrib><creatorcontrib>Chen, Jin-Tang</creatorcontrib><creatorcontrib>Ma, Tso-Chiang</creatorcontrib><creatorcontrib>Chang, Yuan-Shiun</creatorcontrib><title>Analysis of drug–drug interactions (DDIs) in nursing homes in Central Taiwan</title><title>Archives of gerontology and geriatrics</title><addtitle>Arch Gerontol Geriatr</addtitle><description>Abstract With the progressive aging of the population, the long-term nursing care and drug safety for the elderly are gradually gaining attention. In Taiwan, nursing homes are the main institutes helping society or families take care of elderly people suffering from diseases. The aim of this study was to assess the prescribed medications of nursing home residents, the occurrence of DDIs and the association between the number of drugs and DDIs with a view to reinforce drug safety for the elderly. The findings of this study showed that the mean number of medications per resident was 5.74 ± 2.4. Of the 323 samples, 81 (25.1%) had experienced DDIs, 63 (64.95%) were of moderate and 7 (7.2%) of major severity. The findings also showed that the number of potential DDIs increased as the number of medications used per residents increased. The residents with nine or more medications tended to have more DDIs, in comparison to those with one or two medications. The odds ratio (OR) was 11.389, which had reached statistical significance in difference. Therefore, to reduce potential DDIs, the number of medications for the senior people with chronic diseases should be properly controlled.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cross-Sectional Studies</subject><subject>Drug Interactions</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Drug safety</subject><subject>Drug-Related Side Effects and Adverse Reactions - epidemiology</subject><subject>Drugs</subject><subject>Drug–drug interactions (DDIs)</subject><subject>Elderly people</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medication Errors - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Nursing home</subject><subject>Nursing homes</subject><subject>Nursing Homes - statistics & numerical data</subject><subject>Prescriptions</subject><subject>Retrospective Studies</subject><subject>Safety</subject><subject>Taiwan</subject><subject>Taiwan - epidemiology</subject><issn>0167-4943</issn><issn>1872-6976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkc1u1DAUhS0EotPCI4CyQnSRcB07_tmAqim0lSpYUNaW47mZesg4rZ2AZsc78IZ9EhzNSEjddHWkq-_cq3sOIW8oVBSo-LCpbHS3a4xVDSArEFWWZ2RBlaxLoaV4ThaZkyXXnB2R45Q2AMChFi_JEZVKKM3Egnw9C7bfJZ-KoStWcVo__Pk7S-HDiNG60Q8hFe_Pz6_SaZ4VYYrJh3VxO2wxzYMlhjHavrix_rcNr8iLzvYJXx_0hPz48vlmeVlef7u4Wp5dl67hYiyRc9V1de2aVui2lq2SjEvZNUrVtGk1OmHbRmsByEXLFEBnuezQKtVR7QQ7Ie_2e-_icD9hGs3WJ4d9bwMOUzKNZKAUhydBqgVjVPAMNnvQxSGliJ25i35r485QMHPiZmMOiZs5cQPCZMm-t4cDU7vF1X_XIeIMfNoDmPP45bM9OY_B4cpHdKNZDf7JEx8fbXC9D97Z_ifuMG2GKeYS8y8m1QbM97n2uXWQAJQrxv4BjxGpNg</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Liao, Hui-Ling</creator><creator>Chen, Jin-Tang</creator><creator>Ma, Tso-Chiang</creator><creator>Chang, Yuan-Shiun</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>7QJ</scope></search><sort><creationdate>20080701</creationdate><title>Analysis of drug–drug interactions (DDIs) in nursing homes in Central Taiwan</title><author>Liao, Hui-Ling ; Chen, Jin-Tang ; Ma, Tso-Chiang ; Chang, Yuan-Shiun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-e448ff22c5b69b27b873477f588215b9ec6ab59960e46b3800fa47fea88f19c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cross-Sectional Studies</topic><topic>Drug Interactions</topic><topic>Drug Prescriptions - statistics & numerical data</topic><topic>Drug safety</topic><topic>Drug-Related Side Effects and Adverse Reactions - epidemiology</topic><topic>Drugs</topic><topic>Drug–drug interactions (DDIs)</topic><topic>Elderly people</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medication Errors - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Nursing home</topic><topic>Nursing homes</topic><topic>Nursing Homes - statistics & numerical data</topic><topic>Prescriptions</topic><topic>Retrospective Studies</topic><topic>Safety</topic><topic>Taiwan</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Hui-Ling</creatorcontrib><creatorcontrib>Chen, Jin-Tang</creatorcontrib><creatorcontrib>Ma, Tso-Chiang</creatorcontrib><creatorcontrib>Chang, Yuan-Shiun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Archives of gerontology and geriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Hui-Ling</au><au>Chen, Jin-Tang</au><au>Ma, Tso-Chiang</au><au>Chang, Yuan-Shiun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of drug–drug interactions (DDIs) in nursing homes in Central Taiwan</atitle><jtitle>Archives of gerontology and geriatrics</jtitle><addtitle>Arch Gerontol Geriatr</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>47</volume><issue>1</issue><spage>99</spage><epage>107</epage><pages>99-107</pages><issn>0167-4943</issn><eissn>1872-6976</eissn><abstract>Abstract With the progressive aging of the population, the long-term nursing care and drug safety for the elderly are gradually gaining attention. In Taiwan, nursing homes are the main institutes helping society or families take care of elderly people suffering from diseases. The aim of this study was to assess the prescribed medications of nursing home residents, the occurrence of DDIs and the association between the number of drugs and DDIs with a view to reinforce drug safety for the elderly. The findings of this study showed that the mean number of medications per resident was 5.74 ± 2.4. Of the 323 samples, 81 (25.1%) had experienced DDIs, 63 (64.95%) were of moderate and 7 (7.2%) of major severity. The findings also showed that the number of potential DDIs increased as the number of medications used per residents increased. The residents with nine or more medications tended to have more DDIs, in comparison to those with one or two medications. The odds ratio (OR) was 11.389, which had reached statistical significance in difference. Therefore, to reduce potential DDIs, the number of medications for the senior people with chronic diseases should be properly controlled.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>17868936</pmid><doi>10.1016/j.archger.2007.06.007</doi><tpages>9</tpages></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Aged, 80 and over Cross-Sectional Studies Drug Interactions Drug Prescriptions - statistics & numerical data Drug safety Drug-Related Side Effects and Adverse Reactions - epidemiology Drugs Drug–drug interactions (DDIs) Elderly people Female Humans Incidence Internal Medicine Male Medication Errors - statistics & numerical data Middle Aged Nursing home Nursing homes Nursing Homes - statistics & numerical data Prescriptions Retrospective Studies Safety Taiwan Taiwan - epidemiology |
| title | Analysis of drug–drug interactions (DDIs) in nursing homes in Central Taiwan |
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