A randomized trial of short psychotherapy versus sustained‐release bupropion for smoking cessation
ABSTRACT Aims To compare the efficacy and safety of a novel psychological intervention for smoking cessation called psychodynamic model (PDM) training to an active control condition of sustained‐release bupropion. Design Randomized controlled clinical trial with allocation concealment. Setting Pr...
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| Veröffentlicht in: | Addiction (Abingdon, England) England), 2008-12, Vol.103 (12), p.2024-2031 |
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| creator | Zernig, Gerald Wallner, Reinhild Grohs, Ursula Kriechbaum, Norbert Kemmler, Georg Saria, Alois |
| description | ABSTRACT
Aims To compare the efficacy and safety of a novel psychological intervention for smoking cessation called psychodynamic model (PDM) training to an active control condition of sustained‐release bupropion.
Design Randomized controlled clinical trial with allocation concealment.
Setting Private psychiatric practice.
Participants Seven hundred and seventy‐nine adult smokers recruited by advertising.
Interventions PDM training (n = 366 participants) consisted of a very brief (1.5 days) psychoeducation and a supervised training in autosuggestion techniques (guided imageries) aimed at enhancing self‐management, decidedness, assertiveness, security and competence in relationships, natural functions of organs and awareness of bodily functions. Bupropion SR (n = 413) was increased to 150 mg twice daily over 1 week and given over a 8‐week period.
Measurements Twelve‐month continuous abstinence confirmed by exhaled carbon monoxide (CO) of 9 parts per million (p.p.m.) or less at all interviews conducted at 3, 6 and 12 months.
Findings Intention‐to‐treat analysis revealed Russell standard 12‐month continuous abstinence rates of 39.1% in the psychotherapy group versus 12.3% in the bupropion SR group (P |
| doi_str_mv | 10.1111/j.1360-0443.2008.02348.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_57264734</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1594383751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4878-4cc59ccd18c70ebab3a6438937b3a816adf7983960acb7e2f71edf18afa3d9563</originalsourceid><addsrcrecordid>eNqNkc2u1CAYhonReMbRWzDEhbtWKJSfhYvJOf4lJ3Gja0Lhq9OxLRXa4xlXXoLX6JVInYkmbo4khC_wfG-AByFMSUnzeHEoKROkIJyzsiJElaRiXJW399Dmz8F9tCFa1EVFOblAj1I6EEKk0vwhuqCaCy252CC_w9GOPgzdN_B4jp3tcWhx2oc44ykd3T7Me4h2OuIbiGlJOM_ZdiP4n99_ROjBJsDNMsUwdWHEbYg4DeFzN37CDlKyc959jB60tk_w5Lxu0cfXrz5cvi2u3795d7m7LhxXUhXcuVo756lykkBjG2YFZ0ozmStFhfWt1IppQaxrJFStpOBbqmxrmde1YFv0_JSbb_NlgTSboUsO-t6OEJZkalkJLhm_E2SS1EJJeSdItagUz7-_Rc_-AQ9hiWN-bWZ0raUgKkPqBLkYUorQmil2g41HQ4lZxZqDWf2Z1Z9ZxZrfYs1tbn16zl-aAfzfxrPJDLw8AV-7Ho7_HWx2V1drxX4BJj-z-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199597608</pqid></control><display><type>article</type><title>A randomized trial of short psychotherapy versus sustained‐release bupropion for smoking cessation</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Zernig, Gerald ; Wallner, Reinhild ; Grohs, Ursula ; Kriechbaum, Norbert ; Kemmler, Georg ; Saria, Alois</creator><creatorcontrib>Zernig, Gerald ; Wallner, Reinhild ; Grohs, Ursula ; Kriechbaum, Norbert ; Kemmler, Georg ; Saria, Alois</creatorcontrib><description>ABSTRACT
Aims To compare the efficacy and safety of a novel psychological intervention for smoking cessation called psychodynamic model (PDM) training to an active control condition of sustained‐release bupropion.
Design Randomized controlled clinical trial with allocation concealment.
Setting Private psychiatric practice.
Participants Seven hundred and seventy‐nine adult smokers recruited by advertising.
Interventions PDM training (n = 366 participants) consisted of a very brief (1.5 days) psychoeducation and a supervised training in autosuggestion techniques (guided imageries) aimed at enhancing self‐management, decidedness, assertiveness, security and competence in relationships, natural functions of organs and awareness of bodily functions. Bupropion SR (n = 413) was increased to 150 mg twice daily over 1 week and given over a 8‐week period.
Measurements Twelve‐month continuous abstinence confirmed by exhaled carbon monoxide (CO) of 9 parts per million (p.p.m.) or less at all interviews conducted at 3, 6 and 12 months.
Findings Intention‐to‐treat analysis revealed Russell standard 12‐month continuous abstinence rates of 39.1% in the psychotherapy group versus 12.3% in the bupropion SR group (P < 0.001) with a relative benefit (RB) of 3.16 (2.38–4.26). Completer analysis revealed 12‐month continuous abstinence rates of 39.9% in the psychotherapy group versus 22.5% in the bupropion group [P < 0.001; RB 1.78 (1.35–2.34)]. Of note, bupropion abstinence rates were comparable to previous medications/placebo‐only comparisons in geographically different samples.
Conclusions The 1.5‐day psychotherapy exceeded bupropion's efficacy, presenting an alternative to pharmacological smoking cessation aids, especially for smokers who reject drugs to treat their substance dependence, at a similar cost (€350) as the bupropion treatment (€355).</description><identifier>ISSN: 0965-2140</identifier><identifier>EISSN: 1360-0443</identifier><identifier>DOI: 10.1111/j.1360-0443.2008.02348.x</identifier><identifier>PMID: 19469746</identifier><identifier>CODEN: ADICE5</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Abstinence ; Addiction ; Adult ; Bupropion ; Bupropion - adverse effects ; Bupropion - therapeutic use ; Cessation ; Clinical outcomes ; Clinical trials ; Drug therapy ; Efficacy ; Female ; Group psychotherapy ; Humans ; Imagery (Psychotherapy) ; Male ; Methodology ; Middle Aged ; Nicotine dependence ; Patient Compliance ; Prescription drugs ; psychodynamic model training ; Psychotherapy ; Psychotherapy, Brief - methods ; Public health ; Random sampling ; randomized controlled trial ; Smoking ; Smoking - therapy ; Smoking cessation ; Smoking Cessation - methods ; Social problems ; sustained‐release bupropion ; Tobacco Use Disorder - therapy ; Treatment Outcome</subject><ispartof>Addiction (Abingdon, England), 2008-12, Vol.103 (12), p.2024-2031</ispartof><rights>2008 The Authors. Journal compilation © 2008 Society for the Study of Addiction</rights><rights>Journal compilation © 2008 Society for the Study of Addiction</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4878-4cc59ccd18c70ebab3a6438937b3a816adf7983960acb7e2f71edf18afa3d9563</citedby><cites>FETCH-LOGICAL-c4878-4cc59ccd18c70ebab3a6438937b3a816adf7983960acb7e2f71edf18afa3d9563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1360-0443.2008.02348.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1360-0443.2008.02348.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,30977,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19469746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zernig, Gerald</creatorcontrib><creatorcontrib>Wallner, Reinhild</creatorcontrib><creatorcontrib>Grohs, Ursula</creatorcontrib><creatorcontrib>Kriechbaum, Norbert</creatorcontrib><creatorcontrib>Kemmler, Georg</creatorcontrib><creatorcontrib>Saria, Alois</creatorcontrib><title>A randomized trial of short psychotherapy versus sustained‐release bupropion for smoking cessation</title><title>Addiction (Abingdon, England)</title><addtitle>Addiction</addtitle><description>ABSTRACT
Aims To compare the efficacy and safety of a novel psychological intervention for smoking cessation called psychodynamic model (PDM) training to an active control condition of sustained‐release bupropion.
Design Randomized controlled clinical trial with allocation concealment.
Setting Private psychiatric practice.
Participants Seven hundred and seventy‐nine adult smokers recruited by advertising.
Interventions PDM training (n = 366 participants) consisted of a very brief (1.5 days) psychoeducation and a supervised training in autosuggestion techniques (guided imageries) aimed at enhancing self‐management, decidedness, assertiveness, security and competence in relationships, natural functions of organs and awareness of bodily functions. Bupropion SR (n = 413) was increased to 150 mg twice daily over 1 week and given over a 8‐week period.
Measurements Twelve‐month continuous abstinence confirmed by exhaled carbon monoxide (CO) of 9 parts per million (p.p.m.) or less at all interviews conducted at 3, 6 and 12 months.
Findings Intention‐to‐treat analysis revealed Russell standard 12‐month continuous abstinence rates of 39.1% in the psychotherapy group versus 12.3% in the bupropion SR group (P < 0.001) with a relative benefit (RB) of 3.16 (2.38–4.26). Completer analysis revealed 12‐month continuous abstinence rates of 39.9% in the psychotherapy group versus 22.5% in the bupropion group [P < 0.001; RB 1.78 (1.35–2.34)]. Of note, bupropion abstinence rates were comparable to previous medications/placebo‐only comparisons in geographically different samples.
Conclusions The 1.5‐day psychotherapy exceeded bupropion's efficacy, presenting an alternative to pharmacological smoking cessation aids, especially for smokers who reject drugs to treat their substance dependence, at a similar cost (€350) as the bupropion treatment (€355).</description><subject>Abstinence</subject><subject>Addiction</subject><subject>Adult</subject><subject>Bupropion</subject><subject>Bupropion - adverse effects</subject><subject>Bupropion - therapeutic use</subject><subject>Cessation</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Drug therapy</subject><subject>Efficacy</subject><subject>Female</subject><subject>Group psychotherapy</subject><subject>Humans</subject><subject>Imagery (Psychotherapy)</subject><subject>Male</subject><subject>Methodology</subject><subject>Middle Aged</subject><subject>Nicotine dependence</subject><subject>Patient Compliance</subject><subject>Prescription drugs</subject><subject>psychodynamic model training</subject><subject>Psychotherapy</subject><subject>Psychotherapy, Brief - methods</subject><subject>Public health</subject><subject>Random sampling</subject><subject>randomized controlled trial</subject><subject>Smoking</subject><subject>Smoking - therapy</subject><subject>Smoking cessation</subject><subject>Smoking Cessation - methods</subject><subject>Social problems</subject><subject>sustained‐release bupropion</subject><subject>Tobacco Use Disorder - therapy</subject><subject>Treatment Outcome</subject><issn>0965-2140</issn><issn>1360-0443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkc2u1CAYhonReMbRWzDEhbtWKJSfhYvJOf4lJ3Gja0Lhq9OxLRXa4xlXXoLX6JVInYkmbo4khC_wfG-AByFMSUnzeHEoKROkIJyzsiJElaRiXJW399Dmz8F9tCFa1EVFOblAj1I6EEKk0vwhuqCaCy252CC_w9GOPgzdN_B4jp3tcWhx2oc44ykd3T7Me4h2OuIbiGlJOM_ZdiP4n99_ROjBJsDNMsUwdWHEbYg4DeFzN37CDlKyc959jB60tk_w5Lxu0cfXrz5cvi2u3795d7m7LhxXUhXcuVo756lykkBjG2YFZ0ozmStFhfWt1IppQaxrJFStpOBbqmxrmde1YFv0_JSbb_NlgTSboUsO-t6OEJZkalkJLhm_E2SS1EJJeSdItagUz7-_Rc_-AQ9hiWN-bWZ0raUgKkPqBLkYUorQmil2g41HQ4lZxZqDWf2Z1Z9ZxZrfYs1tbn16zl-aAfzfxrPJDLw8AV-7Ho7_HWx2V1drxX4BJj-z-Q</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Zernig, Gerald</creator><creator>Wallner, Reinhild</creator><creator>Grohs, Ursula</creator><creator>Kriechbaum, Norbert</creator><creator>Kemmler, Georg</creator><creator>Saria, Alois</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>7QJ</scope></search><sort><creationdate>200812</creationdate><title>A randomized trial of short psychotherapy versus sustained‐release bupropion for smoking cessation</title><author>Zernig, Gerald ; Wallner, Reinhild ; Grohs, Ursula ; Kriechbaum, Norbert ; Kemmler, Georg ; Saria, Alois</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4878-4cc59ccd18c70ebab3a6438937b3a816adf7983960acb7e2f71edf18afa3d9563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abstinence</topic><topic>Addiction</topic><topic>Adult</topic><topic>Bupropion</topic><topic>Bupropion - adverse effects</topic><topic>Bupropion - therapeutic use</topic><topic>Cessation</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Drug therapy</topic><topic>Efficacy</topic><topic>Female</topic><topic>Group psychotherapy</topic><topic>Humans</topic><topic>Imagery (Psychotherapy)</topic><topic>Male</topic><topic>Methodology</topic><topic>Middle Aged</topic><topic>Nicotine dependence</topic><topic>Patient Compliance</topic><topic>Prescription drugs</topic><topic>psychodynamic model training</topic><topic>Psychotherapy</topic><topic>Psychotherapy, Brief - methods</topic><topic>Public health</topic><topic>Random sampling</topic><topic>randomized controlled trial</topic><topic>Smoking</topic><topic>Smoking - therapy</topic><topic>Smoking cessation</topic><topic>Smoking Cessation - methods</topic><topic>Social problems</topic><topic>sustained‐release bupropion</topic><topic>Tobacco Use Disorder - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zernig, Gerald</creatorcontrib><creatorcontrib>Wallner, Reinhild</creatorcontrib><creatorcontrib>Grohs, Ursula</creatorcontrib><creatorcontrib>Kriechbaum, Norbert</creatorcontrib><creatorcontrib>Kemmler, Georg</creatorcontrib><creatorcontrib>Saria, Alois</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Addiction (Abingdon, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zernig, Gerald</au><au>Wallner, Reinhild</au><au>Grohs, Ursula</au><au>Kriechbaum, Norbert</au><au>Kemmler, Georg</au><au>Saria, Alois</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized trial of short psychotherapy versus sustained‐release bupropion for smoking cessation</atitle><jtitle>Addiction (Abingdon, England)</jtitle><addtitle>Addiction</addtitle><date>2008-12</date><risdate>2008</risdate><volume>103</volume><issue>12</issue><spage>2024</spage><epage>2031</epage><pages>2024-2031</pages><issn>0965-2140</issn><eissn>1360-0443</eissn><coden>ADICE5</coden><abstract>ABSTRACT
Aims To compare the efficacy and safety of a novel psychological intervention for smoking cessation called psychodynamic model (PDM) training to an active control condition of sustained‐release bupropion.
Design Randomized controlled clinical trial with allocation concealment.
Setting Private psychiatric practice.
Participants Seven hundred and seventy‐nine adult smokers recruited by advertising.
Interventions PDM training (n = 366 participants) consisted of a very brief (1.5 days) psychoeducation and a supervised training in autosuggestion techniques (guided imageries) aimed at enhancing self‐management, decidedness, assertiveness, security and competence in relationships, natural functions of organs and awareness of bodily functions. Bupropion SR (n = 413) was increased to 150 mg twice daily over 1 week and given over a 8‐week period.
Measurements Twelve‐month continuous abstinence confirmed by exhaled carbon monoxide (CO) of 9 parts per million (p.p.m.) or less at all interviews conducted at 3, 6 and 12 months.
Findings Intention‐to‐treat analysis revealed Russell standard 12‐month continuous abstinence rates of 39.1% in the psychotherapy group versus 12.3% in the bupropion SR group (P < 0.001) with a relative benefit (RB) of 3.16 (2.38–4.26). Completer analysis revealed 12‐month continuous abstinence rates of 39.9% in the psychotherapy group versus 22.5% in the bupropion group [P < 0.001; RB 1.78 (1.35–2.34)]. Of note, bupropion abstinence rates were comparable to previous medications/placebo‐only comparisons in geographically different samples.
Conclusions The 1.5‐day psychotherapy exceeded bupropion's efficacy, presenting an alternative to pharmacological smoking cessation aids, especially for smokers who reject drugs to treat their substance dependence, at a similar cost (€350) as the bupropion treatment (€355).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19469746</pmid><doi>10.1111/j.1360-0443.2008.02348.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Addiction (Abingdon, England), 2008-12, Vol.103 (12), p.2024-2031 |
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| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library All Journals |
| subjects | Abstinence Addiction Adult Bupropion Bupropion - adverse effects Bupropion - therapeutic use Cessation Clinical outcomes Clinical trials Drug therapy Efficacy Female Group psychotherapy Humans Imagery (Psychotherapy) Male Methodology Middle Aged Nicotine dependence Patient Compliance Prescription drugs psychodynamic model training Psychotherapy Psychotherapy, Brief - methods Public health Random sampling randomized controlled trial Smoking Smoking - therapy Smoking cessation Smoking Cessation - methods Social problems sustained‐release bupropion Tobacco Use Disorder - therapy Treatment Outcome |
| title | A randomized trial of short psychotherapy versus sustained‐release bupropion for smoking cessation |
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