Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users
Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore;...
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| Veröffentlicht in: | AIDS and behavior 2005-09, Vol.9 (3), p.301-309 |
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| creator | Golub, Elizabeth T Purvis, Lisa A Sapun, Marcella Safaeian, Mahboobeh Beyrer, Chris Vlahov, David Strathdee, Steffanie A |
| description | Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials. |
| doi_str_mv | 10.1007/s10461-005-9004-3 |
| format | Article |
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We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.</description><identifier>ISSN: 1090-7165</identifier><identifier>EISSN: 1573-3254</identifier><identifier>DOI: 10.1007/s10461-005-9004-3</identifier><identifier>PMID: 16088366</identifier><identifier>CODEN: AIBEFC</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; AIDS Serodiagnosis ; AIDS Vaccines - administration & dosage ; Clinical trials ; Clinical Trials as Topic ; Drug abusers ; Epidemiology ; Female ; Financial incentives ; HIV ; HIV Infections - diagnosis ; HIV Infections - prevention & control ; Human immunodeficiency virus ; Humans ; Injection ; Interviews as Topic ; Logistic Models ; Male ; Patient Participation - psychology ; Prevention ; Prospective Studies ; Public health ; Questionnaires ; Substance Abuse, Intravenous - complications ; Surveys and Questionnaires ; Vaccines ; Willingness</subject><ispartof>AIDS and behavior, 2005-09, Vol.9 (3), p.301-309</ispartof><rights>Springer Science+Business Media, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-4e817ebe7daee77e3b5842ad0502c5f77593bcf7fc48e6340e98d2c49d982e93</citedby><cites>FETCH-LOGICAL-c388t-4e817ebe7daee77e3b5842ad0502c5f77593bcf7fc48e6340e98d2c49d982e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27344,27924,27925,31000,33774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16088366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golub, Elizabeth T</creatorcontrib><creatorcontrib>Purvis, Lisa A</creatorcontrib><creatorcontrib>Sapun, Marcella</creatorcontrib><creatorcontrib>Safaeian, Mahboobeh</creatorcontrib><creatorcontrib>Beyrer, Chris</creatorcontrib><creatorcontrib>Vlahov, David</creatorcontrib><creatorcontrib>Strathdee, Steffanie A</creatorcontrib><title>Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users</title><title>AIDS and behavior</title><addtitle>AIDS Behav</addtitle><description>Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS Serodiagnosis</subject><subject>AIDS Vaccines - administration & dosage</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Drug abusers</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Financial incentives</subject><subject>HIV</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - prevention & control</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Injection</subject><subject>Interviews as Topic</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Patient Participation - psychology</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Public 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Basic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>AIDS and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golub, Elizabeth T</au><au>Purvis, Lisa A</au><au>Sapun, Marcella</au><au>Safaeian, Mahboobeh</au><au>Beyrer, Chris</au><au>Vlahov, David</au><au>Strathdee, Steffanie A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users</atitle><jtitle>AIDS and behavior</jtitle><addtitle>AIDS Behav</addtitle><date>2005-09</date><risdate>2005</risdate><volume>9</volume><issue>3</issue><spage>301</spage><epage>309</epage><pages>301-309</pages><issn>1090-7165</issn><eissn>1573-3254</eissn><coden>AIBEFC</coden><abstract>Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16088366</pmid><doi>10.1007/s10461-005-9004-3</doi><tpages>9</tpages></addata></record> |
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| ispartof | AIDS and behavior, 2005-09, Vol.9 (3), p.301-309 |
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| source | MEDLINE; Sociological Abstracts; Applied Social Sciences Index & Abstracts (ASSIA); SpringerLink Journals (MCLS) |
| subjects | Acquired immune deficiency syndrome Adult AIDS AIDS Serodiagnosis AIDS Vaccines - administration & dosage Clinical trials Clinical Trials as Topic Drug abusers Epidemiology Female Financial incentives HIV HIV Infections - diagnosis HIV Infections - prevention & control Human immunodeficiency virus Humans Injection Interviews as Topic Logistic Models Male Patient Participation - psychology Prevention Prospective Studies Public health Questionnaires Substance Abuse, Intravenous - complications Surveys and Questionnaires Vaccines Willingness |
| title | Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users |
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