Twelve-Week Outcomes From an Investigation of High-Dose Nicotine Patch Therapy for Heavy Smokers With a Past History of Alcohol Dependence
This study reports findings from an investigation of the efficacy of high-dose nicotine patch (NP) therapy for heavy smokers with a past history of alcohol dependence. One hundred thirty participants were randomly assigned to 42 mg or 21 mg of transdermal nicotine for 4 weeks, followed by an 8-week...
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| Veröffentlicht in: | Psychology of addictive behaviors 2004-03, Vol.18 (1), p.78-82 |
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| container_end_page | 82 |
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| container_issue | 1 |
| container_start_page | 78 |
| container_title | Psychology of addictive behaviors |
| container_volume | 18 |
| creator | Kalman, David Kahler, Christopher W Tirch, Dennis Kaschub, Cynthia Penk, Walter Monti, Peter M |
| description | This study reports findings from an investigation of the efficacy of high-dose nicotine patch (NP) therapy for heavy smokers with a past history of alcohol dependence. One hundred thirty participants were randomly assigned to 42 mg or 21 mg of transdermal nicotine for 4 weeks, followed by an 8-week dose titration. Follow-up assessments were conducted at 4 and 12 weeks. Differences between dose conditions were nonsignificant, although unexpectedly, outcomes favored participants in the 21-mg NP condition. Nicotine abstinence at follow-up was related to longer length of alcohol abstinence at time of enrollment. Future research should investigate ways to improve smoking quit rates in this population, including more frequent counseling sessions and/or other pharmacotherapies. These investigations should focus primarily on smokers in early alcohol recovery. |
| doi_str_mv | 10.1037/0893-164X.18.1.78 |
| format | Article |
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One hundred thirty participants were randomly assigned to 42 mg or 21 mg of transdermal nicotine for 4 weeks, followed by an 8-week dose titration. Follow-up assessments were conducted at 4 and 12 weeks. Differences between dose conditions were nonsignificant, although unexpectedly, outcomes favored participants in the 21-mg NP condition. Nicotine abstinence at follow-up was related to longer length of alcohol abstinence at time of enrollment. Future research should investigate ways to improve smoking quit rates in this population, including more frequent counseling sessions and/or other pharmacotherapies. 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One hundred thirty participants were randomly assigned to 42 mg or 21 mg of transdermal nicotine for 4 weeks, followed by an 8-week dose titration. Follow-up assessments were conducted at 4 and 12 weeks. Differences between dose conditions were nonsignificant, although unexpectedly, outcomes favored participants in the 21-mg NP condition. Nicotine abstinence at follow-up was related to longer length of alcohol abstinence at time of enrollment. Future research should investigate ways to improve smoking quit rates in this population, including more frequent counseling sessions and/or other pharmacotherapies. These investigations should focus primarily on smokers in early alcohol recovery.</description><subject>Administration, Cutaneous</subject><subject>Alcohol Abuse</subject><subject>Alcohol dependence</subject><subject>Alcoholism - psychology</subject><subject>Alcoholism - rehabilitation</subject><subject>Biological and medical sciences</subject><subject>Desintoxication. Drug withdrawal</subject><subject>Double-Blind Method</subject><subject>Drug Abstinence</subject><subject>Drug Dosages</subject><subject>Drug Therapy</subject><subject>Female</subject><subject>Heavy smoking</subject><subject>Human</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nicotine</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotine - adverse effects</subject><subject>Nicotine patches</subject><subject>Outcomes</subject><subject>Patient History</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Smoking - drug therapy</subject><subject>Smoking - psychology</subject><subject>Smoking Cessation</subject><subject>Tobacco Smoking</subject><subject>Treatment Outcomes</subject><subject>Treatments</subject><subject>USA</subject><issn>0893-164X</issn><issn>1939-1501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNpdkd1u1DAQhSMEokvhAbhBFgjusng2f_Zl1VK2UkWRWFTurIkz6bpN4mA7i_IKPDVe7aogrmak-c6ZGZ0keQ18CTyrPnIhsxTK_McSxBKWlXiSLEBmMoWCw9Nk8Tg_SV54f885z7gonycncR4bIRfJ780v6naU3hI9sJspaNuTZ5fO9gwHdjXsyAdzh8HYgdmWrc3dNr2wntgXo20wA7GvGPSWbbbkcJxZax1bE-5m9q23D-Q8uzVhyzBiPkS5D9bNe6ezTtut7dgFjTQ0NGh6mTxrsfP06lhPk--Xnzbn6_T65vPV-dl1ijlkIRUrIataiLpt6pVEqAutBZWFAMxXlUYtMmrrTGY5F0Upcqq0lLoCXTayLSDPTpMPB9_R2Z9T_E_1xmvqOhzITl4VFchcVhDBt_-B93ZyQ7xNlZDnJXBeRggOkHbWe0etGp3p0c0KuNqnpPYpqH0KCoQCVYmoeXM0nuqemr-KYywReH8E0GvsWoeDNv4frpDx11Xk3h04HFGNftbogtEdeYVN_bjuD4enpqQ</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Kalman, David</creator><creator>Kahler, Christopher W</creator><creator>Tirch, Dennis</creator><creator>Kaschub, Cynthia</creator><creator>Penk, Walter</creator><creator>Monti, Peter M</creator><general>Educational Publishing Foundation</general><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7QJ</scope></search><sort><creationdate>20040301</creationdate><title>Twelve-Week Outcomes From an Investigation of High-Dose Nicotine Patch Therapy for Heavy Smokers With a Past History of Alcohol Dependence</title><author>Kalman, David ; Kahler, Christopher W ; Tirch, Dennis ; Kaschub, Cynthia ; Penk, Walter ; Monti, Peter M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a413t-82897b88bfdb29a1b5cc8e6581a427cac83efb3934085684e7c99c71c6d9f5143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Cutaneous</topic><topic>Alcohol Abuse</topic><topic>Alcohol dependence</topic><topic>Alcoholism - psychology</topic><topic>Alcoholism - rehabilitation</topic><topic>Biological and medical sciences</topic><topic>Desintoxication. Drug withdrawal</topic><topic>Double-Blind Method</topic><topic>Drug Abstinence</topic><topic>Drug Dosages</topic><topic>Drug Therapy</topic><topic>Female</topic><topic>Heavy smoking</topic><topic>Human</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nicotine</topic><topic>Nicotine - administration & dosage</topic><topic>Nicotine - adverse effects</topic><topic>Nicotine patches</topic><topic>Outcomes</topic><topic>Patient History</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Smoking - drug therapy</topic><topic>Smoking - psychology</topic><topic>Smoking Cessation</topic><topic>Tobacco Smoking</topic><topic>Treatment Outcomes</topic><topic>Treatments</topic><topic>USA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalman, David</creatorcontrib><creatorcontrib>Kahler, Christopher W</creatorcontrib><creatorcontrib>Tirch, Dennis</creatorcontrib><creatorcontrib>Kaschub, Cynthia</creatorcontrib><creatorcontrib>Penk, Walter</creatorcontrib><creatorcontrib>Monti, Peter M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Access via APA PsycArticles® (ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Psychology of addictive behaviors</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalman, David</au><au>Kahler, Christopher W</au><au>Tirch, Dennis</au><au>Kaschub, Cynthia</au><au>Penk, Walter</au><au>Monti, Peter M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Twelve-Week Outcomes From an Investigation of High-Dose Nicotine Patch Therapy for Heavy Smokers With a Past History of Alcohol Dependence</atitle><jtitle>Psychology of addictive behaviors</jtitle><addtitle>Psychol Addict Behav</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>18</volume><issue>1</issue><spage>78</spage><epage>82</epage><pages>78-82</pages><issn>0893-164X</issn><eissn>1939-1501</eissn><abstract>This study reports findings from an investigation of the efficacy of high-dose nicotine patch (NP) therapy for heavy smokers with a past history of alcohol dependence. One hundred thirty participants were randomly assigned to 42 mg or 21 mg of transdermal nicotine for 4 weeks, followed by an 8-week dose titration. Follow-up assessments were conducted at 4 and 12 weeks. Differences between dose conditions were nonsignificant, although unexpectedly, outcomes favored participants in the 21-mg NP condition. Nicotine abstinence at follow-up was related to longer length of alcohol abstinence at time of enrollment. Future research should investigate ways to improve smoking quit rates in this population, including more frequent counseling sessions and/or other pharmacotherapies. These investigations should focus primarily on smokers in early alcohol recovery.</abstract><cop>Washington, DC</cop><pub>Educational Publishing Foundation</pub><pmid>15008689</pmid><doi>10.1037/0893-164X.18.1.78</doi><tpages>5</tpages></addata></record> |
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| ispartof | Psychology of addictive behaviors, 2004-03, Vol.18 (1), p.78-82 |
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| language | eng |
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| source | MEDLINE; EBSCOhost APA PsycARTICLES; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Administration, Cutaneous Alcohol Abuse Alcohol dependence Alcoholism - psychology Alcoholism - rehabilitation Biological and medical sciences Desintoxication. Drug withdrawal Double-Blind Method Drug Abstinence Drug Dosages Drug Therapy Female Heavy smoking Human Humans Linear Models Male Medical sciences Middle Aged Nicotine Nicotine - administration & dosage Nicotine - adverse effects Nicotine patches Outcomes Patient History Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Smoking - drug therapy Smoking - psychology Smoking Cessation Tobacco Smoking Treatment Outcomes Treatments USA |
| title | Twelve-Week Outcomes From an Investigation of High-Dose Nicotine Patch Therapy for Heavy Smokers With a Past History of Alcohol Dependence |
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