The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats

The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats

Previous findings from our group indicate that accumbal glycine receptors (GlyRs) are involved in mediating the dopamine (DA) activating effects of ethanol (EtOH), and that administration of glycine locally into the nucleus accumbens (nAc) reduces EtOH consumption in EtOH high-preferring rats. Aims:...

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Veröffentlicht in:Alcohol and alcoholism (Oxford) 2007-01, Vol.42 (1), p.11-18
Hauptverfasser: Molander, A, Lidoe, H H, Loef, E, Ericson, M, Soederpalm, B
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Alcohol consumption
Alcohol dependence
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container_title Alcohol and alcoholism (Oxford)
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creator Molander, A
Lidoe, H H
Loef, E
Ericson, M
Soederpalm, B
description Previous findings from our group indicate that accumbal glycine receptors (GlyRs) are involved in mediating the dopamine (DA) activating effects of ethanol (EtOH), and that administration of glycine locally into the nucleus accumbens (nAc) reduces EtOH consumption in EtOH high-preferring rats. Aims: The present study examines the influence of a systemically administered glycine reuptake inhibitor, Org 25935, on EtOH preference and intake, in male Wistar rats with an EtOH preference >60% (during continuous access to a bottle of EtOH, 6% v/v, and a bottle of water), called EP>60 rats, as well as in animals with an EtOH preference
doi_str_mv 10.1093/alcalc/ag1085
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Aims: The present study examines the influence of a systemically administered glycine reuptake inhibitor, Org 25935, on EtOH preference and intake, in male Wistar rats with an EtOH preference &gt;60% (during continuous access to a bottle of EtOH, 6% v/v, and a bottle of water), called EP&gt;60 rats, as well as in animals with an EtOH preference &lt;60%, called EP&lt;60 rats. Org 25935 is an inhibitor of the glycine transporter 1 (GlyT1) protein with negligible action on the glycine transporter 2 (GlyT2) protein. Methods: Both EP&gt;60 and EP&lt;60 rats were limited to drink 2.5 h/day. Org 25935 or vehicle was administered intraperitoneally similar to 40 min before the rats were presented to a choice of drinking EtOH or water. Results: Org 25935 decreased EtOH intake and EtOH preference, as compared with vehicle, whereas water intake was unaffected. 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source Applied Social Sciences Index & Abstracts (ASSIA); Alma/SFX Local Collection; EZB Electronic Journals Library; Oxford Journals
subjects Alcohol consumption
Alcohol dependence
title The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats
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