GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS
Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was...
Gespeichert in:
| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2006-01, Vol.41 (1), p.14-17 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 17 |
|---|---|
| container_issue | 1 |
| container_start_page | 14 |
| container_title | Alcohol and alcoholism (Oxford) |
| container_volume | 41 |
| creator | CICHOŻ-LACH, HALINA PARTYCKA, JADWIGA NESINA, IRINA CELIŃSKI, KRZYSZTOF SŁOMKA, MARIA WOJCIEROWSKI, JACEK |
| description | Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR–restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in alcohol abusers compared with non-drinkers. The examinations of the group of alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of alcohol dependence between genders in the Polish population. |
| doi_str_mv | 10.1093/alcalc/agh225 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_57141394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21235491</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-4c2f1bc3cd322125b6ffa19f5a502ba554538d064cd7ea2c23876e72352be2473</originalsourceid><addsrcrecordid>eNqF0U2P0zAQBmALgdiycOSKIiS4hfX4I26OUZo2lrLxkhTE9mI5rgNd-rHErQT_Hq9abRGXlSz5MM_MaPQi9BbwJ8ApvTJrG96V-f6DEP4MjYAlLKYck-dohAXlMWbALtAr7-8wBkYJvEQXkBCaBjRC21lRF3OZRzequr1WzU0p2-tITaOsylWpqmhSlLeTRgWWtUVEI1k_lir5tWiiXDZNqVrZRlk9-becl42qHyZndd4U2VzOZfsavejN2rs3p_8SfZkW87yMKzWTeVbFlrHxPmaW9NBZapeUECC8S_reQNpzEw7rDOeM0_ESJ8wuhTPEEjoWiROEctI5wgS9RB-Pc--H3a-D83u9WXnr1muzdbuD11wAA5qyJ2HYTjlL4UkIAgtOGA7w_X_wbncYtuFaDek4nEOBBhQfkR123g-u1_fDamOGPxqwfshVH3PVx1yDf3caeug2bnnWpyAD-HACxofGfjBbu_JnJxjHLMHnxSu_d78f62b4qRNBBdflt4XGi894NoVKL-hfkliwSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198221313</pqid></control><display><type>article</type><title>GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>CICHOŻ-LACH, HALINA ; PARTYCKA, JADWIGA ; NESINA, IRINA ; CELIŃSKI, KRZYSZTOF ; SŁOMKA, MARIA ; WOJCIEROWSKI, JACEK</creator><creatorcontrib>CICHOŻ-LACH, HALINA ; PARTYCKA, JADWIGA ; NESINA, IRINA ; CELIŃSKI, KRZYSZTOF ; SŁOMKA, MARIA ; WOJCIEROWSKI, JACEK</creatorcontrib><description>Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR–restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in alcohol abusers compared with non-drinkers. The examinations of the group of alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of alcohol dependence between genders in the Polish population.</description><identifier>ISSN: 0735-0414</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agh225</identifier><identifier>PMID: 16239350</identifier><identifier>CODEN: ALALDD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Alcohol consumption ; Alcohol Dehydrogenase - genetics ; Alcohol related disorders ; Alcoholism and acute alcohol poisoning ; Alleles ; Biological and medical sciences ; DNA Primers - genetics ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic disorders ; Genetics ; Genotype ; Humans ; Liver Cirrhosis, Alcoholic - genetics ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pancreatitis, Alcoholic - genetics ; Pancreatitis, Chronic - genetics ; Polymorphism, Genetic - genetics ; Toxicology</subject><ispartof>Alcohol and alcoholism (Oxford), 2006-01, Vol.41 (1), p.14-17</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jan 20, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-4c2f1bc3cd322125b6ffa19f5a502ba554538d064cd7ea2c23876e72352be2473</citedby><cites>FETCH-LOGICAL-c448t-4c2f1bc3cd322125b6ffa19f5a502ba554538d064cd7ea2c23876e72352be2473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902,30977</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17450460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16239350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CICHOŻ-LACH, HALINA</creatorcontrib><creatorcontrib>PARTYCKA, JADWIGA</creatorcontrib><creatorcontrib>NESINA, IRINA</creatorcontrib><creatorcontrib>CELIŃSKI, KRZYSZTOF</creatorcontrib><creatorcontrib>SŁOMKA, MARIA</creatorcontrib><creatorcontrib>WOJCIEROWSKI, JACEK</creatorcontrib><title>GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol and Alcoholism</addtitle><description>Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR–restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in alcohol abusers compared with non-drinkers. The examinations of the group of alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of alcohol dependence between genders in the Polish population.</description><subject>Alcohol consumption</subject><subject>Alcohol Dehydrogenase - genetics</subject><subject>Alcohol related disorders</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>DNA Primers - genetics</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genetic disorders</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Liver Cirrhosis, Alcoholic - genetics</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pancreatitis, Alcoholic - genetics</subject><subject>Pancreatitis, Chronic - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Toxicology</subject><issn>0735-0414</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqF0U2P0zAQBmALgdiycOSKIiS4hfX4I26OUZo2lrLxkhTE9mI5rgNd-rHErQT_Hq9abRGXlSz5MM_MaPQi9BbwJ8ApvTJrG96V-f6DEP4MjYAlLKYck-dohAXlMWbALtAr7-8wBkYJvEQXkBCaBjRC21lRF3OZRzequr1WzU0p2-tITaOsylWpqmhSlLeTRgWWtUVEI1k_lir5tWiiXDZNqVrZRlk9-becl42qHyZndd4U2VzOZfsavejN2rs3p_8SfZkW87yMKzWTeVbFlrHxPmaW9NBZapeUECC8S_reQNpzEw7rDOeM0_ESJ8wuhTPEEjoWiROEctI5wgS9RB-Pc--H3a-D83u9WXnr1muzdbuD11wAA5qyJ2HYTjlL4UkIAgtOGA7w_X_wbncYtuFaDek4nEOBBhQfkR123g-u1_fDamOGPxqwfshVH3PVx1yDf3caeug2bnnWpyAD-HACxofGfjBbu_JnJxjHLMHnxSu_d78f62b4qRNBBdflt4XGi894NoVKL-hfkliwSw</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>CICHOŻ-LACH, HALINA</creator><creator>PARTYCKA, JADWIGA</creator><creator>NESINA, IRINA</creator><creator>CELIŃSKI, KRZYSZTOF</creator><creator>SŁOMKA, MARIA</creator><creator>WOJCIEROWSKI, JACEK</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7QJ</scope></search><sort><creationdate>20060101</creationdate><title>GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS</title><author>CICHOŻ-LACH, HALINA ; PARTYCKA, JADWIGA ; NESINA, IRINA ; CELIŃSKI, KRZYSZTOF ; SŁOMKA, MARIA ; WOJCIEROWSKI, JACEK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-4c2f1bc3cd322125b6ffa19f5a502ba554538d064cd7ea2c23876e72352be2473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alcohol consumption</topic><topic>Alcohol Dehydrogenase - genetics</topic><topic>Alcohol related disorders</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>DNA Primers - genetics</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genetic disorders</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Liver Cirrhosis, Alcoholic - genetics</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pancreatitis, Alcoholic - genetics</topic><topic>Pancreatitis, Chronic - genetics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CICHOŻ-LACH, HALINA</creatorcontrib><creatorcontrib>PARTYCKA, JADWIGA</creatorcontrib><creatorcontrib>NESINA, IRINA</creatorcontrib><creatorcontrib>CELIŃSKI, KRZYSZTOF</creatorcontrib><creatorcontrib>SŁOMKA, MARIA</creatorcontrib><creatorcontrib>WOJCIEROWSKI, JACEK</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CICHOŻ-LACH, HALINA</au><au>PARTYCKA, JADWIGA</au><au>NESINA, IRINA</au><au>CELIŃSKI, KRZYSZTOF</au><au>SŁOMKA, MARIA</au><au>WOJCIEROWSKI, JACEK</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol and Alcoholism</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>41</volume><issue>1</issue><spage>14</spage><epage>17</epage><pages>14-17</pages><issn>0735-0414</issn><eissn>1464-3502</eissn><coden>ALALDD</coden><abstract>Aim: To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. Method: The ADH3 genotype and ADH3*1 and ADH3*2 alleles frequencies were examined in 198 patients. Genotyping of the ADH3 was performed using PCR–restriction fragment length polymorphism methods on a white cell DNA. Results: The genotype ADH3*1/ADH3*1 was found to be significantly more frequent in alcohol abusers compared with non-drinkers. The examinations of the group of alcohol abusers showed that the genotype ADH3*2/ADH3*2 occurred statistically significantly less frequently in patients with chronic pancreatitis than in those without alimentary lesions (healthy drinkers). The alleles ADH3*1 and genotype ADH3*1/ADH3*1 were significantly more frequent in men than in women, whereas alleles ADH3*2 and genotype ADH3*2/ADH3*2 were more common in women. Conclusions: The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis. Variations in ADH3 genotypes may account for some of the differences in prevalence of alcohol dependence between genders in the Polish population.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16239350</pmid><doi>10.1093/alcalc/agh225</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-0414 |
| ispartof | Alcohol and alcoholism (Oxford), 2006-01, Vol.41 (1), p.14-17 |
| issn | 0735-0414 1464-3502 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_57141394 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alcohol consumption Alcohol Dehydrogenase - genetics Alcohol related disorders Alcoholism and acute alcohol poisoning Alleles Biological and medical sciences DNA Primers - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Genetic disorders Genetics Genotype Humans Liver Cirrhosis, Alcoholic - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Pancreatitis, Alcoholic - genetics Pancreatitis, Chronic - genetics Polymorphism, Genetic - genetics Toxicology |
| title | GENETIC POLYMORPHISM OF ALCOHOL DEHYDROGENASE 3 IN ALCOHOL LIVER CIRRHOSIS AND IN ALCOHOL CHRONIC PANCREATITIS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T02%3A08%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=GENETIC%20POLYMORPHISM%20OF%20ALCOHOL%20DEHYDROGENASE%203%20IN%20ALCOHOL%20LIVER%20CIRRHOSIS%20AND%20IN%20ALCOHOL%20CHRONIC%20PANCREATITIS&rft.jtitle=Alcohol%20and%20alcoholism%20(Oxford)&rft.au=CICHOZ%CC%87-LACH,%20HALINA&rft.date=2006-01-01&rft.volume=41&rft.issue=1&rft.spage=14&rft.epage=17&rft.pages=14-17&rft.issn=0735-0414&rft.eissn=1464-3502&rft.coden=ALALDD&rft_id=info:doi/10.1093/alcalc/agh225&rft_dat=%3Cproquest_cross%3E21235491%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=198221313&rft_id=info:pmid/16239350&rfr_iscdi=true |