Buprenorphine in pregnant opioid-dependent women: first results of a prospective study
ABSTRACT Aim To report results on the prospective follow‐up of 34 pregnant women exposed to buprenorphine maintenance for opiate dependence. Design and setting Prospective multicentre study: all pregnant women receiving buprenorphine as maintenance therapy were included as early as possible during...
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| Veröffentlicht in: | Addiction (Abingdon, England) England), 2004-02, Vol.99 (2), p.209-214 |
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| creator | Lacroix, I. Berrebi, A. Chaumerliac, C. Lapeyre-Mestre, M. Montastruc, J. L. Damase-Michel, C. |
| description | ABSTRACT
Aim To report results on the prospective follow‐up of 34 pregnant women exposed to buprenorphine maintenance for opiate dependence.
Design and setting Prospective multicentre study: all pregnant women receiving buprenorphine as maintenance therapy were included as early as possible during their pregnancy.
Participants The pregnant women were recruited from opiate maintenance therapy centres, general practitioner‐networks involved in addiction, maternity hospitals and centres for drug information during pregnancy.
Measurements Women: drugs and medications consumed, medical and obstetrical events; offspring: withdrawal syndrome, malformation, neonatal disease.
Findings The buprenorphine‐exposed pregnancies resulted in 31 live births, one stillbirth, one spontaneous abortion and one voluntary termination. A neonatal withdrawal syndrome was observed in 13 cases (41.9%) and eight of these babies required opiate treatment. Two neonates had a malformation: a premature ductus arteriosus stricture and a tragus appendix.
Conclusion Taken together with other prospective studies, no alarming results were observed concerning pregnancy outcomes. However, further data from the comparative prospective study are required to determine whether buprenorphine can be considered as a good alternative to methadone treatment in pregnant women. |
| doi_str_mv | 10.1046/j.1360-0443.2003.00600.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_57137234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>57137234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5460-5a214fc7d30440dab6b6927a032dd10302596eee0351ad8f44decbc7c82cd6143</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhS0EosPAX0AREuwSruNXgti00weICiQe7dLy2DfgIeOEOKEz_74eZtRKbGBl-_o7V-foEJJRKChw-XpVUCYhB85ZUQKwAkACFJsHZHb38ZDMoJYiLymHI_IkxhUAqKrmj8kR5UpIRdmMXJ1M_YChG_ofPmDmQ5ae34MJY9b1vvMud9hjcJgGN90aw5us8UMcswHj1I4x65rMJE0Xe7Sj_41ZHCe3fUoeNaaN-Oxwzsm387Ovi3f55aeL94vjy9wKnnwKk9w1VjmWHIMzS7mUdakMsNI5CgxKUUtEBCaocVXDuUO7tMpWpXWScjYnr_Z7k4NfE8ZRr3202LYmYDdFLVJIVbJ_g0xVlaCgEvjiL3DVTUNIITStayEFq8sEVXvIpuBxwEb3g1-bYasp6F1DeqV3RehdEXrXkP7TkN4k6fPD_mm5RncvPFSSgJcHwERr2mYwwfp4zwlBK0jgnLzdcze-xe1_G9DHp6fpkuT5Xu7jiJs7uRl-aqmYEvr644X-cHV9vvjyudKc3QJJJLqE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199565392</pqid></control><display><type>article</type><title>Buprenorphine in pregnant opioid-dependent women: first results of a prospective study</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lacroix, I. ; Berrebi, A. ; Chaumerliac, C. ; Lapeyre-Mestre, M. ; Montastruc, J. L. ; Damase-Michel, C.</creator><creatorcontrib>Lacroix, I. ; Berrebi, A. ; Chaumerliac, C. ; Lapeyre-Mestre, M. ; Montastruc, J. L. ; Damase-Michel, C.</creatorcontrib><description>ABSTRACT
Aim To report results on the prospective follow‐up of 34 pregnant women exposed to buprenorphine maintenance for opiate dependence.
Design and setting Prospective multicentre study: all pregnant women receiving buprenorphine as maintenance therapy were included as early as possible during their pregnancy.
Participants The pregnant women were recruited from opiate maintenance therapy centres, general practitioner‐networks involved in addiction, maternity hospitals and centres for drug information during pregnancy.
Measurements Women: drugs and medications consumed, medical and obstetrical events; offspring: withdrawal syndrome, malformation, neonatal disease.
Findings The buprenorphine‐exposed pregnancies resulted in 31 live births, one stillbirth, one spontaneous abortion and one voluntary termination. A neonatal withdrawal syndrome was observed in 13 cases (41.9%) and eight of these babies required opiate treatment. Two neonates had a malformation: a premature ductus arteriosus stricture and a tragus appendix.
Conclusion Taken together with other prospective studies, no alarming results were observed concerning pregnancy outcomes. However, further data from the comparative prospective study are required to determine whether buprenorphine can be considered as a good alternative to methadone treatment in pregnant women.</description><identifier>ISSN: 0965-2140</identifier><identifier>EISSN: 1360-0443</identifier><identifier>DOI: 10.1046/j.1360-0443.2003.00600.x</identifier><identifier>PMID: 14756713</identifier><identifier>CODEN: ADICE5</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Addictions ; Adult ; Biological and medical sciences ; Buprenorphine ; Buprenorphine - therapeutic use ; Comparative analysis ; Drug abuse ; Drug addiction ; Drug addictions ; Drug dependency ; Drug use ; epidemiological study ; Epidemiology ; Female ; Follow-Up Studies ; France ; Health ; Humans ; Infant, Newborn ; Information ; malformation ; Medical sciences ; Methadone ; Narcotics - therapeutic use ; Neonatal Abstinence Syndrome - etiology ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Opiates ; Outcomes ; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Complications - rehabilitation ; Pregnancy Outcome ; Pregnant women ; Prospective Studies ; Social problems ; Substance abuse treatment ; Substance-Related Disorders - rehabilitation ; Toxicology ; Treatment ; withdrawal syndrome</subject><ispartof>Addiction (Abingdon, England), 2004-02, Vol.99 (2), p.209-214</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Carfax Publishing Company Feb 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5460-5a214fc7d30440dab6b6927a032dd10302596eee0351ad8f44decbc7c82cd6143</citedby><cites>FETCH-LOGICAL-c5460-5a214fc7d30440dab6b6927a032dd10302596eee0351ad8f44decbc7c82cd6143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1360-0443.2003.00600.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1360-0443.2003.00600.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,30977,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15518071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14756713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lacroix, I.</creatorcontrib><creatorcontrib>Berrebi, A.</creatorcontrib><creatorcontrib>Chaumerliac, C.</creatorcontrib><creatorcontrib>Lapeyre-Mestre, M.</creatorcontrib><creatorcontrib>Montastruc, J. L.</creatorcontrib><creatorcontrib>Damase-Michel, C.</creatorcontrib><title>Buprenorphine in pregnant opioid-dependent women: first results of a prospective study</title><title>Addiction (Abingdon, England)</title><addtitle>Addiction</addtitle><description>ABSTRACT
Aim To report results on the prospective follow‐up of 34 pregnant women exposed to buprenorphine maintenance for opiate dependence.
Design and setting Prospective multicentre study: all pregnant women receiving buprenorphine as maintenance therapy were included as early as possible during their pregnancy.
Participants The pregnant women were recruited from opiate maintenance therapy centres, general practitioner‐networks involved in addiction, maternity hospitals and centres for drug information during pregnancy.
Measurements Women: drugs and medications consumed, medical and obstetrical events; offspring: withdrawal syndrome, malformation, neonatal disease.
Findings The buprenorphine‐exposed pregnancies resulted in 31 live births, one stillbirth, one spontaneous abortion and one voluntary termination. A neonatal withdrawal syndrome was observed in 13 cases (41.9%) and eight of these babies required opiate treatment. Two neonates had a malformation: a premature ductus arteriosus stricture and a tragus appendix.
Conclusion Taken together with other prospective studies, no alarming results were observed concerning pregnancy outcomes. However, further data from the comparative prospective study are required to determine whether buprenorphine can be considered as a good alternative to methadone treatment in pregnant women.</description><subject>Addictions</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Buprenorphine</subject><subject>Buprenorphine - therapeutic use</subject><subject>Comparative analysis</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Drug addictions</subject><subject>Drug dependency</subject><subject>Drug use</subject><subject>epidemiological study</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>France</subject><subject>Health</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Information</subject><subject>malformation</subject><subject>Medical sciences</subject><subject>Methadone</subject><subject>Narcotics - therapeutic use</subject><subject>Neonatal Abstinence Syndrome - etiology</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Opiates</subject><subject>Outcomes</subject><subject>Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - rehabilitation</subject><subject>Pregnancy Outcome</subject><subject>Pregnant women</subject><subject>Prospective Studies</subject><subject>Social problems</subject><subject>Substance abuse treatment</subject><subject>Substance-Related Disorders - rehabilitation</subject><subject>Toxicology</subject><subject>Treatment</subject><subject>withdrawal syndrome</subject><issn>0965-2140</issn><issn>1360-0443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkUtv1DAUhS0EosPAX0AREuwSruNXgti00weICiQe7dLy2DfgIeOEOKEz_74eZtRKbGBl-_o7V-foEJJRKChw-XpVUCYhB85ZUQKwAkACFJsHZHb38ZDMoJYiLymHI_IkxhUAqKrmj8kR5UpIRdmMXJ1M_YChG_ofPmDmQ5ae34MJY9b1vvMud9hjcJgGN90aw5us8UMcswHj1I4x65rMJE0Xe7Sj_41ZHCe3fUoeNaaN-Oxwzsm387Ovi3f55aeL94vjy9wKnnwKk9w1VjmWHIMzS7mUdakMsNI5CgxKUUtEBCaocVXDuUO7tMpWpXWScjYnr_Z7k4NfE8ZRr3202LYmYDdFLVJIVbJ_g0xVlaCgEvjiL3DVTUNIITStayEFq8sEVXvIpuBxwEb3g1-bYasp6F1DeqV3RehdEXrXkP7TkN4k6fPD_mm5RncvPFSSgJcHwERr2mYwwfp4zwlBK0jgnLzdcze-xe1_G9DHp6fpkuT5Xu7jiJs7uRl-aqmYEvr644X-cHV9vvjyudKc3QJJJLqE</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Lacroix, I.</creator><creator>Berrebi, A.</creator><creator>Chaumerliac, C.</creator><creator>Lapeyre-Mestre, M.</creator><creator>Montastruc, J. L.</creator><creator>Damase-Michel, C.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope></search><sort><creationdate>200402</creationdate><title>Buprenorphine in pregnant opioid-dependent women: first results of a prospective study</title><author>Lacroix, I. ; Berrebi, A. ; Chaumerliac, C. ; Lapeyre-Mestre, M. ; Montastruc, J. L. ; Damase-Michel, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5460-5a214fc7d30440dab6b6927a032dd10302596eee0351ad8f44decbc7c82cd6143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Addictions</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Buprenorphine</topic><topic>Buprenorphine - therapeutic use</topic><topic>Comparative analysis</topic><topic>Drug abuse</topic><topic>Drug addiction</topic><topic>Drug addictions</topic><topic>Drug dependency</topic><topic>Drug use</topic><topic>epidemiological study</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>France</topic><topic>Health</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Information</topic><topic>malformation</topic><topic>Medical sciences</topic><topic>Methadone</topic><topic>Narcotics - therapeutic use</topic><topic>Neonatal Abstinence Syndrome - etiology</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Opiates</topic><topic>Outcomes</topic><topic>Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - rehabilitation</topic><topic>Pregnancy Outcome</topic><topic>Pregnant women</topic><topic>Prospective Studies</topic><topic>Social problems</topic><topic>Substance abuse treatment</topic><topic>Substance-Related Disorders - rehabilitation</topic><topic>Toxicology</topic><topic>Treatment</topic><topic>withdrawal syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lacroix, I.</creatorcontrib><creatorcontrib>Berrebi, A.</creatorcontrib><creatorcontrib>Chaumerliac, C.</creatorcontrib><creatorcontrib>Lapeyre-Mestre, M.</creatorcontrib><creatorcontrib>Montastruc, J. L.</creatorcontrib><creatorcontrib>Damase-Michel, C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Addiction (Abingdon, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lacroix, I.</au><au>Berrebi, A.</au><au>Chaumerliac, C.</au><au>Lapeyre-Mestre, M.</au><au>Montastruc, J. L.</au><au>Damase-Michel, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Buprenorphine in pregnant opioid-dependent women: first results of a prospective study</atitle><jtitle>Addiction (Abingdon, England)</jtitle><addtitle>Addiction</addtitle><date>2004-02</date><risdate>2004</risdate><volume>99</volume><issue>2</issue><spage>209</spage><epage>214</epage><pages>209-214</pages><issn>0965-2140</issn><eissn>1360-0443</eissn><coden>ADICE5</coden><abstract>ABSTRACT
Aim To report results on the prospective follow‐up of 34 pregnant women exposed to buprenorphine maintenance for opiate dependence.
Design and setting Prospective multicentre study: all pregnant women receiving buprenorphine as maintenance therapy were included as early as possible during their pregnancy.
Participants The pregnant women were recruited from opiate maintenance therapy centres, general practitioner‐networks involved in addiction, maternity hospitals and centres for drug information during pregnancy.
Measurements Women: drugs and medications consumed, medical and obstetrical events; offspring: withdrawal syndrome, malformation, neonatal disease.
Findings The buprenorphine‐exposed pregnancies resulted in 31 live births, one stillbirth, one spontaneous abortion and one voluntary termination. A neonatal withdrawal syndrome was observed in 13 cases (41.9%) and eight of these babies required opiate treatment. Two neonates had a malformation: a premature ductus arteriosus stricture and a tragus appendix.
Conclusion Taken together with other prospective studies, no alarming results were observed concerning pregnancy outcomes. However, further data from the comparative prospective study are required to determine whether buprenorphine can be considered as a good alternative to methadone treatment in pregnant women.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>14756713</pmid><doi>10.1046/j.1360-0443.2003.00600.x</doi><tpages>6</tpages></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Addictions Adult Biological and medical sciences Buprenorphine Buprenorphine - therapeutic use Comparative analysis Drug abuse Drug addiction Drug addictions Drug dependency Drug use epidemiological study Epidemiology Female Follow-Up Studies France Health Humans Infant, Newborn Information malformation Medical sciences Methadone Narcotics - therapeutic use Neonatal Abstinence Syndrome - etiology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Opiates Outcomes Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Pregnancy Pregnancy Complications - rehabilitation Pregnancy Outcome Pregnant women Prospective Studies Social problems Substance abuse treatment Substance-Related Disorders - rehabilitation Toxicology Treatment withdrawal syndrome |
| title | Buprenorphine in pregnant opioid-dependent women: first results of a prospective study |
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