Effects of a Synthetic Predator Odor (TMT) on Freezing, Analgesia, Stereotypy, and Spatial Memory
Exposing rats to the predator odor of trimethylthiazoline (TMT), obtained from the red fox, was compared to exposure to the novel control odor of citronella. In Experiment 1, TMT produced defensive freezing and an analgesic reaction that was reversed by an opiate antagonist. In Experiment 2, TMT aug...
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| Veröffentlicht in: | The Psychological record 2005, Vol.55 (1), p.3-38 |
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| creator | Williams, Jon L Baez, Catherine Hladky, Katherine J Camacho, Cheri A |
| description | Exposing rats to the predator odor of trimethylthiazoline (TMT), obtained from the red fox, was compared to exposure to the novel control odor of citronella. In Experiment 1, TMT produced defensive freezing and an analgesic reaction that was reversed by an opiate antagonist. In Experiment 2, TMT augmented response stereotypy induced by an amphetamine injection. In Experiment 3, TMT interfered with working memory during 30-s, but not 0-s, delay trials of a spatial-alternation task. However, a larger amount of TMT disrupted performance during delay and no-delay trials. In Experiment 4, TMT impaired the recall of the location of a hidden platform in a Morris water maze, and a preexposure injection of a benzodiazepine agonist prevented this deficit. These findings and their implications are discussed in terms of research involving similar paradigms with other stressors. |
| doi_str_mv | 10.1007/BF03395496 |
| format | Article |
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These findings and their implications are discussed in terms of research involving similar paradigms with other stressors.</description><subject>Amphetamines</subject><subject>Analgesics</subject><subject>Fear</subject><subject>Feedback (Response)</subject><subject>Freezing</subject><subject>Helplessness</subject><subject>Injections</subject><subject>Laboratories</subject><subject>Memory</subject><subject>Odors</subject><subject>Odours</subject><subject>Positive Reinforcement</subject><subject>Researchers</subject><subject>Risk Assessment</subject><subject>Rodents</subject><subject>Short Term Memory</subject><subject>Stereotypes</subject><subject>Stimulation</subject><subject>Stimuli</subject><subject>Stress</subject><issn>0033-2933</issn><issn>2163-3452</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0M9LwzAUB_AgCs7pxbOH4EFUVs2PJm2Pc2z-YGPC5rlkyevs6JqaZIf611uZKHh5Dx4fvvC-CJ1TckcJSe4fJoTzTMSZPEA9RiWPeCzYIeqR7h6xjPNjdOL9hhBCY5L0kBoXBejgsS2wwou2Du8QSo1fHRgVrMNz043r5Wx5g22NJw7gs6zXAzysVbUGX6oBXgRwYEPbtAOsaoMXjQqlqvAMtta1p-ioUJWHs5_dR2-T8XL0FE3nj8-j4TTSjIkQ6TijCRUpNUSYgkmhaRpLpo2IAUgqipVepSoViscyNhJWhComUs1JQlJjgPfR1T63cfZjBz7k29JrqCpVg935XCSUZUyIDl7-gxu7c907PmeUyUSkhHXodo-0s947KPLGlVvl2pyS_Lvq_K_qDl_sMbhS_8Lxi8xkJhj_Ap1ad4s</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Williams, Jon L</creator><creator>Baez, Catherine</creator><creator>Hladky, Katherine J</creator><creator>Camacho, Cheri A</creator><general>The Psychological Record, Kenyon College, Gambier, OH</general><general>Springer Nature B.V</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>4U-</scope><scope>7QJ</scope><scope>7XB</scope><scope>88B</scope><scope>88G</scope><scope>88I</scope><scope>88J</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>HEHIP</scope><scope>M0P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>2005</creationdate><title>Effects of a Synthetic Predator Odor (TMT) on Freezing, Analgesia, Stereotypy, and Spatial Memory</title><author>Williams, Jon L ; 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| subjects | Amphetamines Analgesics Fear Feedback (Response) Freezing Helplessness Injections Laboratories Memory Odors Odours Positive Reinforcement Researchers Risk Assessment Rodents Short Term Memory Stereotypes Stimulation Stimuli Stress |
| title | Effects of a Synthetic Predator Odor (TMT) on Freezing, Analgesia, Stereotypy, and Spatial Memory |
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