The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology
The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology . Anda R.F., Felitti V.J., Bremner J.D., Walker J.D., Whitfield C., Perry B.D., Dube S.R. & Giles W.H. ( 2005 ) European Archives of Psychiatry and Clinical...
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| Veröffentlicht in: | Child : care, health & development health & development, 2006-03, Vol.32 (2), p.253-256 |
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| creator | Reading, Richard |
| description | The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology
.
Anda R.F.,
Felitti V.J.,
Bremner J.D.,
Walker J.D.,
Whitfield C.,
Perry B.D.,
Dube S.R. &
Giles W.H.
(
2005
)
European Archives of Psychiatry and Clinical Neuroscience
,
ePub, posted online 29 November 2005
.
Background Childhood maltreatment has been linked to a variety of changes in brain structure and function and stress–responsive neurobiological systems. Epidemiological studies have documented the impact of childhood maltreatment on health and emotional well‐being.
Methods After a brief review of the neurobiology of childhood trauma, we use the Adverse Childhood Experiences (ACE) Study as an epidemiological ‘case example’ of the convergence between epidemiological and neurobiological evidence of the effects of childhood trauma. The ACE Study included 17 337 adult HMO (Health Maintenance Organization) members and assessed eight adverse childhood experiences (ACEs) including abuse, witnessing domestic violence, and serious household dysfunction. We used the number of ACEs (ACE score) as a measure of cumulative childhood stress and hypothesized a ‘dose–response’ relationship of the ACE score to 18 selected outcomes and to the total number of these outcomes (comorbidity).
Results Based upon logistic regression analysis, the risk of every outcome in the affective, somatic, substance abuse, memory, sexual, and aggression‐related domains increased in a graded fashion as the ACE score increased (P |
| doi_str_mv | 10.1111/j.1365-2214.2006.00614_2.x |
| format | Article |
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.
Anda R.F.,
Felitti V.J.,
Bremner J.D.,
Walker J.D.,
Whitfield C.,
Perry B.D.,
Dube S.R. &
Giles W.H.
(
2005
)
European Archives of Psychiatry and Clinical Neuroscience
,
ePub, posted online 29 November 2005
.
Background Childhood maltreatment has been linked to a variety of changes in brain structure and function and stress–responsive neurobiological systems. Epidemiological studies have documented the impact of childhood maltreatment on health and emotional well‐being.
Methods After a brief review of the neurobiology of childhood trauma, we use the Adverse Childhood Experiences (ACE) Study as an epidemiological ‘case example’ of the convergence between epidemiological and neurobiological evidence of the effects of childhood trauma. The ACE Study included 17 337 adult HMO (Health Maintenance Organization) members and assessed eight adverse childhood experiences (ACEs) including abuse, witnessing domestic violence, and serious household dysfunction. We used the number of ACEs (ACE score) as a measure of cumulative childhood stress and hypothesized a ‘dose–response’ relationship of the ACE score to 18 selected outcomes and to the total number of these outcomes (comorbidity).
Results Based upon logistic regression analysis, the risk of every outcome in the affective, somatic, substance abuse, memory, sexual, and aggression‐related domains increased in a graded fashion as the ACE score increased (P < 0.001). The mean number of comorbid outcomes tripled across the range of the ACE score.
Conclusions The graded relationship of the ACE score to 18 different outcomes in multiple domains theoretically parallels the cumulative exposure of the developing brain to the stress response with resulting impairment in multiple brain structures and functions.</description><identifier>ISSN: 0305-1862</identifier><identifier>EISSN: 1365-2214</identifier><identifier>DOI: 10.1111/j.1365-2214.2006.00614_2.x</identifier><identifier>CODEN: CCHDDH</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adults ; Brain ; Child abuse & neglect ; Childhood abuse ; Childhood maltreatment ; Epidemiology ; Evidence ; Family Violence ; Health maintenance organizations ; HMOs ; Mental health ; Neurobiology ; Neurosciences ; Organic Chemistry ; Regression analysis ; Stress ; Studies ; Substance Abuse</subject><ispartof>Child : care, health & development, 2006-03, Vol.32 (2), p.253-256</ispartof><rights>Copyright Blackwell Publishing Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2942-4dbec03e95f2154db832a8d04bdfa68436270642d693b7eebb83affaa6bbf1713</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2214.2006.00614_2.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2214.2006.00614_2.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>313,314,780,784,792,1417,27922,27924,27925,30999,31000,45574,45575</link.rule.ids></links><search><creatorcontrib>Reading, Richard</creatorcontrib><title>The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology</title><title>Child : care, health & development</title><description>The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology
.
Anda R.F.,
Felitti V.J.,
Bremner J.D.,
Walker J.D.,
Whitfield C.,
Perry B.D.,
Dube S.R. &
Giles W.H.
(
2005
)
European Archives of Psychiatry and Clinical Neuroscience
,
ePub, posted online 29 November 2005
.
Background Childhood maltreatment has been linked to a variety of changes in brain structure and function and stress–responsive neurobiological systems. Epidemiological studies have documented the impact of childhood maltreatment on health and emotional well‐being.
Methods After a brief review of the neurobiology of childhood trauma, we use the Adverse Childhood Experiences (ACE) Study as an epidemiological ‘case example’ of the convergence between epidemiological and neurobiological evidence of the effects of childhood trauma. The ACE Study included 17 337 adult HMO (Health Maintenance Organization) members and assessed eight adverse childhood experiences (ACEs) including abuse, witnessing domestic violence, and serious household dysfunction. We used the number of ACEs (ACE score) as a measure of cumulative childhood stress and hypothesized a ‘dose–response’ relationship of the ACE score to 18 selected outcomes and to the total number of these outcomes (comorbidity).
Results Based upon logistic regression analysis, the risk of every outcome in the affective, somatic, substance abuse, memory, sexual, and aggression‐related domains increased in a graded fashion as the ACE score increased (P < 0.001). The mean number of comorbid outcomes tripled across the range of the ACE score.
Conclusions The graded relationship of the ACE score to 18 different outcomes in multiple domains theoretically parallels the cumulative exposure of the developing brain to the stress response with resulting impairment in multiple brain structures and functions.</description><subject>Adults</subject><subject>Brain</subject><subject>Child abuse & neglect</subject><subject>Childhood abuse</subject><subject>Childhood maltreatment</subject><subject>Epidemiology</subject><subject>Evidence</subject><subject>Family Violence</subject><subject>Health maintenance organizations</subject><subject>HMOs</subject><subject>Mental health</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Organic Chemistry</subject><subject>Regression analysis</subject><subject>Stress</subject><subject>Studies</subject><subject>Substance Abuse</subject><issn>0305-1862</issn><issn>1365-2214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqVkU1v1DAQhi0EEsvCf7B64JbUX3ESbmVFW6QWLuXjZjnxeNdL1l7sTdn9B_xsnKbqgQtiJMvjmXceafwidEZJSXOcb0vKZVUwRkXJCJFlPlQoVh6focVT6zlaEE6qgjaSvUSvUtqSHFKQBfp9twEM3ozR-TUGa6E_JBws1t2YAGtvcIRBH8Bgbe4h5hoc9xAd-B4Sdh73GzeYTQimxBe4Dz6L1lNzgsC9Mw-5jWGHPYwxdC4MYX16IMM-t3dz4TV6YfWQ4M3jvURfLj_cra6Lm89XH1cXN0XPWsEKYTroCYe2soxW-dVwphtDRGeslo3gktV5M2Zky7saoMsCba3WsussrSlforczdx_DzxHSQe1c6mEYtIcwJlXVlEjekH8KJ1jbthPx7C_hNozR5yUUy7_OyQRconezqI8hpQhW7aPb6XhSlKjJSrVVk19q8ktNVqpHK9UxD7-fh3-5AU7_MalWq-s5ZRlSzBCXDnB8guj4Q8ma15X69ulKXQpRf729bdR3_gf9ObeG</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Reading, Richard</creator><general>Blackwell Science Ltd</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>200603</creationdate><title>The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology</title><author>Reading, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2942-4dbec03e95f2154db832a8d04bdfa68436270642d693b7eebb83affaa6bbf1713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adults</topic><topic>Brain</topic><topic>Child abuse & neglect</topic><topic>Childhood abuse</topic><topic>Childhood maltreatment</topic><topic>Epidemiology</topic><topic>Evidence</topic><topic>Family Violence</topic><topic>Health maintenance organizations</topic><topic>HMOs</topic><topic>Mental health</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Organic Chemistry</topic><topic>Regression analysis</topic><topic>Stress</topic><topic>Studies</topic><topic>Substance Abuse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reading, Richard</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Child : care, health & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reading, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology</atitle><jtitle>Child : care, health & development</jtitle><date>2006-03</date><risdate>2006</risdate><volume>32</volume><issue>2</issue><spage>253</spage><epage>256</epage><pages>253-256</pages><issn>0305-1862</issn><eissn>1365-2214</eissn><coden>CCHDDH</coden><abstract>The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology
.
Anda R.F.,
Felitti V.J.,
Bremner J.D.,
Walker J.D.,
Whitfield C.,
Perry B.D.,
Dube S.R. &
Giles W.H.
(
2005
)
European Archives of Psychiatry and Clinical Neuroscience
,
ePub, posted online 29 November 2005
.
Background Childhood maltreatment has been linked to a variety of changes in brain structure and function and stress–responsive neurobiological systems. Epidemiological studies have documented the impact of childhood maltreatment on health and emotional well‐being.
Methods After a brief review of the neurobiology of childhood trauma, we use the Adverse Childhood Experiences (ACE) Study as an epidemiological ‘case example’ of the convergence between epidemiological and neurobiological evidence of the effects of childhood trauma. The ACE Study included 17 337 adult HMO (Health Maintenance Organization) members and assessed eight adverse childhood experiences (ACEs) including abuse, witnessing domestic violence, and serious household dysfunction. We used the number of ACEs (ACE score) as a measure of cumulative childhood stress and hypothesized a ‘dose–response’ relationship of the ACE score to 18 selected outcomes and to the total number of these outcomes (comorbidity).
Results Based upon logistic regression analysis, the risk of every outcome in the affective, somatic, substance abuse, memory, sexual, and aggression‐related domains increased in a graded fashion as the ACE score increased (P < 0.001). The mean number of comorbid outcomes tripled across the range of the ACE score.
Conclusions The graded relationship of the ACE score to 18 different outcomes in multiple domains theoretically parallels the cumulative exposure of the developing brain to the stress response with resulting impairment in multiple brain structures and functions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><doi>10.1111/j.1365-2214.2006.00614_2.x</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | Access via Wiley Online Library; Applied Social Sciences Index & Abstracts (ASSIA); EBSCOhost Education Source |
| subjects | Adults Brain Child abuse & neglect Childhood abuse Childhood maltreatment Epidemiology Evidence Family Violence Health maintenance organizations HMOs Mental health Neurobiology Neurosciences Organic Chemistry Regression analysis Stress Studies Substance Abuse |
| title | The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology |
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