A randomized controlled trial of monetary incentives vs. outreach to enhance adherence to the hepatitis B vaccine series among injection drug users
Background: Injection drug users (IDUs) are at high-risk for hepatitis B virus (HBV) and HIV. Due to concerns about non-adherence to multi-dose vaccine regimens however, IDUs are severely under-immunized against HBV and have been excluded from phase III trials of multi-dose candidate HIV vaccines in...
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| Veröffentlicht in: | Drug and alcohol dependence 2003-08, Vol.71 (2), p.127-131 |
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| creator | Seal, Karen H. Kral, Alex H. Lorvick, Jennifer McNees, Alex Gee, Lauren Edlin, Brian R. |
| description | Background: Injection drug users (IDUs) are at high-risk for hepatitis B virus (HBV) and HIV. Due to concerns about non-adherence to multi-dose vaccine regimens however, IDUs are severely under-immunized against HBV and have been excluded from phase III trials of multi-dose candidate HIV vaccines in the United States.
Methods: Through a randomized controlled trial, we compared the effectiveness of monetary incentives versus outreach to improve IDUs’ adherence to the 3-dose hepatitis B vaccine. In 1998–1999, HBV-susceptible IDUs were recruited from San Francisco streets. Eligible participants received their first dose of vaccine and were randomized to either receive monthly monetary incentives (
n=48) or maintain weekly contact with an outreach worker (
n=48) during the 6-month vaccine series.
Results: All 3 doses of vaccine were received by 33 (69%) of IDUs in the monetary incentive arm and 11 (23%) in the outreach arm (odds ratio=13.8; 95% confidence interval, 2.9, 128;
P |
| doi_str_mv | 10.1016/S0376-8716(03)00074-7 |
| format | Article |
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Methods: Through a randomized controlled trial, we compared the effectiveness of monetary incentives versus outreach to improve IDUs’ adherence to the 3-dose hepatitis B vaccine. In 1998–1999, HBV-susceptible IDUs were recruited from San Francisco streets. Eligible participants received their first dose of vaccine and were randomized to either receive monthly monetary incentives (
n=48) or maintain weekly contact with an outreach worker (
n=48) during the 6-month vaccine series.
Results: All 3 doses of vaccine were received by 33 (69%) of IDUs in the monetary incentive arm and 11 (23%) in the outreach arm (odds ratio=13.8; 95% confidence interval, 2.9, 128;
P<0.0001). In a multivariate model, receiving monetary incentives was independently associated with vaccine completion (AOR=10.3; 95% CI=3.7, 29.0).
Conclusions: Among IDUs, monetary incentives are superior to outreach in achieving adherence to the multi-dose hepatitis B vaccine series. Monetary incentives may be adapted to future multi-dose candidate HIV vaccine trials in IDUs.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/S0376-8716(03)00074-7</identifier><identifier>PMID: 12927650</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Chi-Square Distribution ; Community-Institutional Relations ; Compliance ; Confidence Intervals ; Contingency contracting ; Contingency contracts ; Female ; Financial incentives ; Hepatitis ; Hepatitis B ; Hepatitis B Vaccines - economics ; Hepatitis B Vaccines - therapeutic use ; Hepatitis B virus ; Human viral diseases ; Humans ; Immunization ; Infectious diseases ; Intravenous drug addicts ; Intravenous drug users ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Motivation ; Odds Ratio ; Outreach work ; Patient Compliance - psychology ; Patient Compliance - statistics & numerical data ; Randomized controlled trials ; Substance Abuse, Intravenous - drug therapy ; Substance Abuse, Intravenous - economics ; Substance Abuse, Intravenous - psychology ; Treatment ; USA ; Vaccination ; Viral diseases ; Viral hepatitis</subject><ispartof>Drug and alcohol dependence, 2003-08, Vol.71 (2), p.127-131</ispartof><rights>2003 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-a79c185c33767c4f0b107d826fda74f81a153b1b2966a80930e6903d2b4a1f0f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0376871603000747$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15080395$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12927650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seal, Karen H.</creatorcontrib><creatorcontrib>Kral, Alex H.</creatorcontrib><creatorcontrib>Lorvick, Jennifer</creatorcontrib><creatorcontrib>McNees, Alex</creatorcontrib><creatorcontrib>Gee, Lauren</creatorcontrib><creatorcontrib>Edlin, Brian R.</creatorcontrib><title>A randomized controlled trial of monetary incentives vs. outreach to enhance adherence to the hepatitis B vaccine series among injection drug users</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Background: Injection drug users (IDUs) are at high-risk for hepatitis B virus (HBV) and HIV. Due to concerns about non-adherence to multi-dose vaccine regimens however, IDUs are severely under-immunized against HBV and have been excluded from phase III trials of multi-dose candidate HIV vaccines in the United States.
Methods: Through a randomized controlled trial, we compared the effectiveness of monetary incentives versus outreach to improve IDUs’ adherence to the 3-dose hepatitis B vaccine. In 1998–1999, HBV-susceptible IDUs were recruited from San Francisco streets. Eligible participants received their first dose of vaccine and were randomized to either receive monthly monetary incentives (
n=48) or maintain weekly contact with an outreach worker (
n=48) during the 6-month vaccine series.
Results: All 3 doses of vaccine were received by 33 (69%) of IDUs in the monetary incentive arm and 11 (23%) in the outreach arm (odds ratio=13.8; 95% confidence interval, 2.9, 128;
P<0.0001). In a multivariate model, receiving monetary incentives was independently associated with vaccine completion (AOR=10.3; 95% CI=3.7, 29.0).
Conclusions: Among IDUs, monetary incentives are superior to outreach in achieving adherence to the multi-dose hepatitis B vaccine series. Monetary incentives may be adapted to future multi-dose candidate HIV vaccine trials in IDUs.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Community-Institutional Relations</subject><subject>Compliance</subject><subject>Confidence Intervals</subject><subject>Contingency contracting</subject><subject>Contingency contracts</subject><subject>Female</subject><subject>Financial incentives</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B Vaccines - economics</subject><subject>Hepatitis B Vaccines - therapeutic use</subject><subject>Hepatitis B virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infectious diseases</subject><subject>Intravenous drug addicts</subject><subject>Intravenous drug users</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motivation</subject><subject>Odds Ratio</subject><subject>Outreach work</subject><subject>Patient Compliance - psychology</subject><subject>Patient Compliance - statistics & numerical data</subject><subject>Randomized controlled trials</subject><subject>Substance Abuse, Intravenous - drug therapy</subject><subject>Substance Abuse, Intravenous - economics</subject><subject>Substance Abuse, Intravenous - psychology</subject><subject>Treatment</subject><subject>USA</subject><subject>Vaccination</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkcFu1DAQhi1ERbeFRwD5AoJDyjhO7ORUlapApUo9FM6WY08aV0m82M5K8Bq8ME53RY89eeT55rfn_wl5y-CMAROf74BLUTSSiY_APwGArAr5gmxYI9sCoBIvyeY_ckxOYnzIEIgWXpFjVralFDVsyN8LGvRs_eT-oKXGzyn4ccxlCk6P1Pd08jMmHX5TNxuck9thpLt4Rv2SAmoz0OQpzoPOXartgAHXKl-mAemAW51ccpF-oTttjJuRRgwua-gsfJ9FH9Ak52dqw3JPl9yMr8lRr8eIbw7nKfn59erH5ffi5vbb9eXFTWGqmqdCy9awpjY8bylN1UPHQNqmFL3VsuobplnNO9aVrRC6gZYD5u25LbtKsx56fko-7HW3wf9aMCY1uWhwHPWMfomqliAEVOxZkLVlVUK7gvUeNMHHGLBX2-CmbJ5ioNbY1GNsas1EAVePsSmZ594dHli6Ce3T1CGnDLw_ADoaPfY5M-PiE1dDA7ytM3e-5zD7tnMYVDRuDcS6kH1W1rtnvvIPCCO2AA</recordid><startdate>20030820</startdate><enddate>20030820</enddate><creator>Seal, Karen H.</creator><creator>Kral, Alex H.</creator><creator>Lorvick, Jennifer</creator><creator>McNees, Alex</creator><creator>Gee, Lauren</creator><creator>Edlin, Brian R.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7QJ</scope></search><sort><creationdate>20030820</creationdate><title>A randomized controlled trial of monetary incentives vs. outreach to enhance adherence to the hepatitis B vaccine series among injection drug users</title><author>Seal, Karen H. ; Kral, Alex H. ; Lorvick, Jennifer ; McNees, Alex ; Gee, Lauren ; Edlin, Brian R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-a79c185c33767c4f0b107d826fda74f81a153b1b2966a80930e6903d2b4a1f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Community-Institutional Relations</topic><topic>Compliance</topic><topic>Confidence Intervals</topic><topic>Contingency contracting</topic><topic>Contingency contracts</topic><topic>Female</topic><topic>Financial incentives</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B Vaccines - economics</topic><topic>Hepatitis B Vaccines - therapeutic use</topic><topic>Hepatitis B virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infectious diseases</topic><topic>Intravenous drug addicts</topic><topic>Intravenous drug users</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motivation</topic><topic>Odds Ratio</topic><topic>Outreach work</topic><topic>Patient Compliance - psychology</topic><topic>Patient Compliance - statistics & numerical data</topic><topic>Randomized controlled trials</topic><topic>Substance Abuse, Intravenous - drug therapy</topic><topic>Substance Abuse, Intravenous - economics</topic><topic>Substance Abuse, Intravenous - psychology</topic><topic>Treatment</topic><topic>USA</topic><topic>Vaccination</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seal, Karen H.</creatorcontrib><creatorcontrib>Kral, Alex H.</creatorcontrib><creatorcontrib>Lorvick, Jennifer</creatorcontrib><creatorcontrib>McNees, Alex</creatorcontrib><creatorcontrib>Gee, Lauren</creatorcontrib><creatorcontrib>Edlin, Brian R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seal, Karen H.</au><au>Kral, Alex H.</au><au>Lorvick, Jennifer</au><au>McNees, Alex</au><au>Gee, Lauren</au><au>Edlin, Brian R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized controlled trial of monetary incentives vs. outreach to enhance adherence to the hepatitis B vaccine series among injection drug users</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2003-08-20</date><risdate>2003</risdate><volume>71</volume><issue>2</issue><spage>127</spage><epage>131</epage><pages>127-131</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>Background: Injection drug users (IDUs) are at high-risk for hepatitis B virus (HBV) and HIV. Due to concerns about non-adherence to multi-dose vaccine regimens however, IDUs are severely under-immunized against HBV and have been excluded from phase III trials of multi-dose candidate HIV vaccines in the United States.
Methods: Through a randomized controlled trial, we compared the effectiveness of monetary incentives versus outreach to improve IDUs’ adherence to the 3-dose hepatitis B vaccine. In 1998–1999, HBV-susceptible IDUs were recruited from San Francisco streets. Eligible participants received their first dose of vaccine and were randomized to either receive monthly monetary incentives (
n=48) or maintain weekly contact with an outreach worker (
n=48) during the 6-month vaccine series.
Results: All 3 doses of vaccine were received by 33 (69%) of IDUs in the monetary incentive arm and 11 (23%) in the outreach arm (odds ratio=13.8; 95% confidence interval, 2.9, 128;
P<0.0001). In a multivariate model, receiving monetary incentives was independently associated with vaccine completion (AOR=10.3; 95% CI=3.7, 29.0).
Conclusions: Among IDUs, monetary incentives are superior to outreach in achieving adherence to the multi-dose hepatitis B vaccine series. Monetary incentives may be adapted to future multi-dose candidate HIV vaccine trials in IDUs.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12927650</pmid><doi>10.1016/S0376-8716(03)00074-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 2003-08, Vol.71 (2), p.127-131 |
| issn | 0376-8716 1879-0046 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_57066041 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Biological and medical sciences Chi-Square Distribution Community-Institutional Relations Compliance Confidence Intervals Contingency contracting Contingency contracts Female Financial incentives Hepatitis Hepatitis B Hepatitis B Vaccines - economics Hepatitis B Vaccines - therapeutic use Hepatitis B virus Human viral diseases Humans Immunization Infectious diseases Intravenous drug addicts Intravenous drug users Logistic Models Male Medical sciences Middle Aged Motivation Odds Ratio Outreach work Patient Compliance - psychology Patient Compliance - statistics & numerical data Randomized controlled trials Substance Abuse, Intravenous - drug therapy Substance Abuse, Intravenous - economics Substance Abuse, Intravenous - psychology Treatment USA Vaccination Viral diseases Viral hepatitis |
| title | A randomized controlled trial of monetary incentives vs. outreach to enhance adherence to the hepatitis B vaccine series among injection drug users |
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