Hypochlorite-modified Low Density Lipoprotein Inhibits Nitric Oxide Synthesis in Endothelial Cells via an Intracellular Dislocalization of Endothelial Nitric-oxide Synthase

Hypochlorous acid/hypochlorite, generated by the myeloperoxidase/H 2 O 2 /halide system of activated phagocytes, has been shown to oxidize/modify low density lipoprotein (LDL) in vitro and may be involved in the formation of atherogenic lipoproteins in vivo . Accordingly, hypochlorite-modified (lipo...

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Veröffentlicht in:	The Journal of biological chemistry 2001-04, Vol.276 (17), p.14212-14221
Hauptverfasser:	Nuszkowski, A, Gräbner, R, Marsche, G, Unbehaun, A, Malle, E, Heller, R
Format:	Artikel
Sprache:	eng
Schlagworte:	analogs & derivatives anions Antioxidants Antioxidants - pharmacology arginine Arginine - pharmacokinetics Biopterins Biopterins - analogs & derivatives Biopterins - biosynthesis biosynthesis Blotting, Western cell lines Cell Membrane Cell Membrane - metabolism Cells, Cultured Centrifugation, Density Gradient chlorine citrulline Citrulline - biosynthesis cyclic GMP Cyclic GMP - metabolism Cyclodextrins Cyclodextrins - pharmacology cytochemistry cytology Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel endothelium Endothelium, Vascular Endothelium, Vascular - cytology Endothelium, Vascular - enzymology enzymology Golgi apparatus Golgi Apparatus - metabolism Humans Hypochlorous Acid Hypochlorous Acid - metabolism Immunoblotting Immunohistochemistry inorganic acids Ionomycin Ionomycin - pharmacology Ionophores Ionophores - pharmacology Lipoproteins, LDL Lipoproteins, LDL - metabolism low density lipoprotein metabolism Microscopy, Fluorescence Myristic Acids Myristic Acids - metabolism nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III oxygenases Palmitic Acids Palmitic Acids - metabolism pharmacokinetics pharmacology plasma membrane Precipitin Tests protein transport RNA, Messenger RNA, Messenger - metabolism sodium hypochlorite Subcellular Fractions Subcellular Fractions - metabolism Sucrose Sucrose - metabolism Time Factors Umbilical Veins Umbilical Veins - cytology
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