Cytotoxicity of the MEIC reference chemicals in antioxidant-enriched, rat hepatoma-derived Fa32 cells

Since vitamin E increases the antioxidant status of cells, its influence on cytotoxicity was investigated. The neutral red uptake (NRU) inhibition effects of 39 MEIC reference chemicals were measured after treatment of rat hepatoma-derived Fa32 cells in the presence of vitamin E for 30 minutes. The...

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Veröffentlicht in:	Alternatives to laboratory animals 2001-05, Vol.29 (3), p.217-223
Hauptverfasser:	Dierickx, P J, Smit, C, Scheers, E M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - toxicity animal use replacement Animals antioxidants Antioxidants - pharmacology caffeine Caffeine - toxicity cultured cells cytotoxicity dose response Dose-Response Relationship, Drug drug effects glutathione Glutathione - metabolism hepatocytes humans In Vitro Techniques Inhibitory Concentration 50 liver neoplasms Liver Neoplasms, Experimental Liver Neoplasms, Experimental - metabolism mechanism of action metabolism methods Oxidative Stress Oxidative Stress - drug effects pharmacology prediction Rats Reference Standards Reproducibility of Results sodium chloride Sodium Chloride - toxicity toxicity Toxicity Tests Toxicity Tests - methods Toxicity Tests - standards Tumor Cells, Cultured vitamin E Vitamin E - pharmacology
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