Drug metabolism and interactions in abuse liability assessment

The interpretation of acute abuse liability studies and drug interaction studies would be importantly strengthened by the routine inclusion of drug concentration measurements at appropriate sampling times. Reliance on mean kinetic data misrepresents the variation in drug kinetics and fails to take e...

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Bibliographische Detailangaben

Veröffentlicht in:	Addiction (Abingdon, England) England), 1991-12, Vol.86 (12), p.1607-1614
Hauptverfasser:	SELLERS, EDWARD M., OTTON, S. VICTORIA, BUSTO, USOA E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Dose-Response Relationship, Drug Drug Evaluation - methods Drug Interactions - physiology Drug toxicity and drugs side effects treatment Humans Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Psychotropic Drugs - adverse effects Psychotropic Drugs - pharmacokinetics Risk Factors Substance-Related Disorders - blood Substance-Related Disorders - prevention & control
Online-Zugang:	Volltext
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