Development of a Screening Approach to Interpret Human Biomonitoring Data on Volatile Organic Compounds: Reverse Dosimetry on Biomonitoring Data for Trichloroethylene

A screening approach is developed for volatile organic compounds (VOCs) to estimate exposures that correspond to levels measured in fluids and/or tissues in human biomonitoring studies. The approach makes use of a generic physiologically-based pharmacokinetic (PBPK) model coupled with exposure patte...

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Veröffentlicht in:	Risk analysis 2007-10, Vol.27 (5), p.1223-1236
Hauptverfasser:	Liao, Kai H, Tan, Yu-Mei, Clewell, Harvey J. III
Format:	Artikel
Sprache:	eng
Schlagworte:	Biometrics Chemicals Contamination Data Interpretation, Statistical Dosimetry Drinking water Environmental Exposure Environmental Monitoring - methods Environmental Monitoring - statistics & numerical data Humans Models, Statistical Monte Carlo Monte Carlo Method Monte Carlo simulation Organic Chemicals - analysis Organic Chemicals - blood Organic Chemicals - pharmacokinetics PBPK modeling Pollution control Public health QSPR reverse dosimetry Risk Assessment Risk management Studies trichloroethylene Trichloroethylene - analysis Trichloroethylene - blood Trichloroethylene - pharmacokinetics VOCs Volatile organic compounds Volatilization Water Pollutants, Chemical - analysis Water Pollutants, Chemical - blood Water Pollutants, Chemical - pharmacokinetics
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