Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

A range of human degenerative conditions, including Alzheimer's disease, light-chain amyloidosis and the spongiform encephalopathies, is associated with the deposition in tissue of proteinaceous aggregates known as amyloid fibrils or plaques. It has been shown previously that fibrillar aggregat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2002-04, Vol.416 (6880), p.507-511
Hauptverfasser:	Bucciantini, Monica, Giannoni, Elisa, Chiti, Fabrizio, Baroni, Fabiana, Formigli, Lucia, Zurdo, Jesús, Taddei, Niccolò, Ramponi, Giampietro, Dobson, Christopher M., Stefani, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Aggregates Alzheimer Disease - etiology Alzheimer Disease - pathology Alzheimer's disease Animals Bacterial Proteins - chemistry Bacterial Proteins - toxicity Bacterial Proteins - ultrastructure Biological and medical sciences Biological Evolution Cytotoxins Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease E coli Escherichia coli Genealogy Humanities and Social Sciences Humans HypF protein Medical sciences Mice multidisciplinary Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism Neurology PC12 Cells Phosphatidylinositol 3-Kinases - chemistry Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol 3-Kinases - ultrastructure Plaque, Amyloid - chemistry Plaque, Amyloid - metabolism Protein Folding Proteins Rats Recombinant Proteins - chemistry Science Science (multidisciplinary) src Homology Domains Tissues Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!