Utilization of diets amended with yeast and amino acids for the control of aflatoxicosis

Although the effects of aflatoxin on animal performance have been well established in previous studies, there are few studies reporting on the relationship between aflatoxin and Saccharomyces cerevisiae. The ability of Saccharomyces cerevisiae to minimize aflatoxicosis was evaluated. An aflatoxin-free diet and six contaminated diets (400 μg kg⁻¹ aflatoxin) were formulated with five diets containing the viable yeast (Y1026 or Y904). A 28-day bioassay using 21-day-old and 60-g body weight Wistar rats was conducted. The results showed that there were no significant (P > 0.05) differences for: food consumption; daily weight gain; food conversion, and enzyme activity. Hepatic tissues from the aflatoxin control group suffered from hepatotoxicity, cellular disorganization, and hepatocyte necrosis. The inclusion of yeast or yeast and amino acids (methionine and cysteine) reduced the toxicity.