ATRP synthesis and association properties of temperature responsive dextran copolymers grafted with poly( N-isopropylacrylamide)
Temperature responsive copolymers of dextran grafted with poly( N-isopropylacrylamide) (Dex- g-PNIPAAM) were prepared by atom transfer radical polymerization (ATRP) in homogeneous mild conditions without using protecting group chemistry. Dextran macroinitiator was synthesized by reaction of dextran...
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| Veröffentlicht in: | European polymer journal 2009-10, Vol.45 (10), p.2779-2787 |
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| container_title | European polymer journal |
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| creator | Patrizi, Maria Loreta Piantanida, Giovanna Coluzza, Carlo Masci, Giancarlo |
| description | Temperature responsive copolymers of dextran grafted with poly(
N-isopropylacrylamide) (Dex-
g-PNIPAAM) were prepared by atom transfer radical polymerization (ATRP) in homogeneous mild conditions without using protecting group chemistry. Dextran macroinitiator was synthesized by reaction of dextran with 2-chloropropionyl chloride at room temperature in DMF containing 2% LiCl. ATRP was carried out in DMF:water 50:50 (v/v) mixtures at room temperature with CuBr/Tris(2-dimethylaminoethyl)amine (Me
6TREN) as catalyst. Several grafted copolymers with well defined number and length of low polydispersity grafted chains were prepared. Temperature induced association properties in aqueous solution were studied as a function of temperature and polymer concentration by dynamic light scattering, fluorescence spectroscopy and atomic force microscopy (AFM). LCST, ranging from 35 to 41
°C, was significantly affected by number and length of grafted chains. The fine tuning of LCST around body temperature is an important characteristic not obtainable by conventional radical grafting of PNIPAAM. Well defined spherical nanoparticles were formed above the LCST of PNIPAAM. Hydrodynamic diameter was in the range 73–98
nm. |
| doi_str_mv | 10.1016/j.eurpolymj.2009.07.003 |
| format | Article |
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N-isopropylacrylamide) (Dex-
g-PNIPAAM) were prepared by atom transfer radical polymerization (ATRP) in homogeneous mild conditions without using protecting group chemistry. Dextran macroinitiator was synthesized by reaction of dextran with 2-chloropropionyl chloride at room temperature in DMF containing 2% LiCl. ATRP was carried out in DMF:water 50:50 (v/v) mixtures at room temperature with CuBr/Tris(2-dimethylaminoethyl)amine (Me
6TREN) as catalyst. Several grafted copolymers with well defined number and length of low polydispersity grafted chains were prepared. Temperature induced association properties in aqueous solution were studied as a function of temperature and polymer concentration by dynamic light scattering, fluorescence spectroscopy and atomic force microscopy (AFM). LCST, ranging from 35 to 41
°C, was significantly affected by number and length of grafted chains. The fine tuning of LCST around body temperature is an important characteristic not obtainable by conventional radical grafting of PNIPAAM. Well defined spherical nanoparticles were formed above the LCST of PNIPAAM. Hydrodynamic diameter was in the range 73–98
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N-isopropylacrylamide) (Dex-
g-PNIPAAM) were prepared by atom transfer radical polymerization (ATRP) in homogeneous mild conditions without using protecting group chemistry. Dextran macroinitiator was synthesized by reaction of dextran with 2-chloropropionyl chloride at room temperature in DMF containing 2% LiCl. ATRP was carried out in DMF:water 50:50 (v/v) mixtures at room temperature with CuBr/Tris(2-dimethylaminoethyl)amine (Me
6TREN) as catalyst. Several grafted copolymers with well defined number and length of low polydispersity grafted chains were prepared. Temperature induced association properties in aqueous solution were studied as a function of temperature and polymer concentration by dynamic light scattering, fluorescence spectroscopy and atomic force microscopy (AFM). LCST, ranging from 35 to 41
°C, was significantly affected by number and length of grafted chains. The fine tuning of LCST around body temperature is an important characteristic not obtainable by conventional radical grafting of PNIPAAM. Well defined spherical nanoparticles were formed above the LCST of PNIPAAM. Hydrodynamic diameter was in the range 73–98
nm.</description><subject>Applied sciences</subject><subject>Atom transfer radical polymerization</subject><subject>Exact sciences and technology</subject><subject>Graft</subject><subject>Nanoparticles</subject><subject>Natural polymers</subject><subject>Physicochemistry of polymers</subject><subject>Poly( N-isopropylacrylamide)</subject><subject>Polysaccharides</subject><subject>Starch and polysaccharides</subject><subject>Thermosensitive</subject><issn>0014-3057</issn><issn>1873-1945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi1EJZaW34AvIDgkHTtOvDmuKr6kChDau-W1J9SrJA4eb2Fv_el42apXLjOamXe-HsZeC6gFiO56X-MhLXE8TvtaAvQ16BqgecZWYq2bSvSqfc5WAEJVDbT6BXtJtAcA3XTNij1stj--czrO-Q4pELez55YoumBziDNfUlww5YDE48AzTiWy-ZCQJ6QlzhTukXv8k5OduYv_7sBE_GeyQ0bPf4d8x0_Zd_xrFSie5h1H61IxU_D4_opdDHYkfPXoL9n244ftzefq9tunLzeb28o1usuVQ9l5pyXu-kGjRNmKdd_1ti8fqx3IYe1KDcAL2aFw0nVKe93ulNJ2UL65ZG_PY8sBvw5I2UyBHI6jnTEeyBQYHbSyKUJ9FroUiRIOZklhsuloBJgTcLM3T8DNCbgBbQrw0vnmcYUlZ8ehEHGBntqlBKmEkkW3OeuwvHsfMBlyAWeHPiR02fgY_rvrL59in1I</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Patrizi, Maria Loreta</creator><creator>Piantanida, Giovanna</creator><creator>Coluzza, Carlo</creator><creator>Masci, Giancarlo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20091001</creationdate><title>ATRP synthesis and association properties of temperature responsive dextran copolymers grafted with poly( N-isopropylacrylamide)</title><author>Patrizi, Maria Loreta ; Piantanida, Giovanna ; Coluzza, Carlo ; Masci, Giancarlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-ce26dc72eb9f7e2e2518969a90094b02f8c2eb00d126e1c2c647d75b447af4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Applied sciences</topic><topic>Atom transfer radical polymerization</topic><topic>Exact sciences and technology</topic><topic>Graft</topic><topic>Nanoparticles</topic><topic>Natural polymers</topic><topic>Physicochemistry of polymers</topic><topic>Poly( N-isopropylacrylamide)</topic><topic>Polysaccharides</topic><topic>Starch and polysaccharides</topic><topic>Thermosensitive</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patrizi, Maria Loreta</creatorcontrib><creatorcontrib>Piantanida, Giovanna</creatorcontrib><creatorcontrib>Coluzza, Carlo</creatorcontrib><creatorcontrib>Masci, Giancarlo</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>European polymer journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patrizi, Maria Loreta</au><au>Piantanida, Giovanna</au><au>Coluzza, Carlo</au><au>Masci, Giancarlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ATRP synthesis and association properties of temperature responsive dextran copolymers grafted with poly( N-isopropylacrylamide)</atitle><jtitle>European polymer journal</jtitle><date>2009-10-01</date><risdate>2009</risdate><volume>45</volume><issue>10</issue><spage>2779</spage><epage>2787</epage><pages>2779-2787</pages><issn>0014-3057</issn><eissn>1873-1945</eissn><coden>EUPJAG</coden><abstract>Temperature responsive copolymers of dextran grafted with poly(
N-isopropylacrylamide) (Dex-
g-PNIPAAM) were prepared by atom transfer radical polymerization (ATRP) in homogeneous mild conditions without using protecting group chemistry. Dextran macroinitiator was synthesized by reaction of dextran with 2-chloropropionyl chloride at room temperature in DMF containing 2% LiCl. ATRP was carried out in DMF:water 50:50 (v/v) mixtures at room temperature with CuBr/Tris(2-dimethylaminoethyl)amine (Me
6TREN) as catalyst. Several grafted copolymers with well defined number and length of low polydispersity grafted chains were prepared. Temperature induced association properties in aqueous solution were studied as a function of temperature and polymer concentration by dynamic light scattering, fluorescence spectroscopy and atomic force microscopy (AFM). LCST, ranging from 35 to 41
°C, was significantly affected by number and length of grafted chains. The fine tuning of LCST around body temperature is an important characteristic not obtainable by conventional radical grafting of PNIPAAM. Well defined spherical nanoparticles were formed above the LCST of PNIPAAM. Hydrodynamic diameter was in the range 73–98
nm.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.eurpolymj.2009.07.003</doi><tpages>9</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Applied sciences Atom transfer radical polymerization Exact sciences and technology Graft Nanoparticles Natural polymers Physicochemistry of polymers Poly( N-isopropylacrylamide) Polysaccharides Starch and polysaccharides Thermosensitive |
| title | ATRP synthesis and association properties of temperature responsive dextran copolymers grafted with poly( N-isopropylacrylamide) |
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