Role for copper in the cellular and regulatory effects of heme-hemopexin

Hemopexin (HPX) binds heme tightly, thus protecting cells from heme toxicity during hemolysis, trauma and ischemia-reperfusion injury. Heme uptake via endocytosis of heme-HPX followed by heme catabolism by heme oxygenase-1 (HMOX1) raises regulatory iron pools, thus linking heme metabolism with that...

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Veröffentlicht in:	Biometals 2009-06, Vol.22 (3), p.421-437
Hauptverfasser:	Smith, Ann, Rish, Kimberly R., Lovelace, Rachel, Hackney, Jennifer F., Helston, Rachel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biophysics Cell Biology Cell Line, Tumor Cobalt Copper Copper - chemistry Copper - deficiency Copper - physiology Endocytosis Endocytosis - drug effects Endosomes - metabolism Enzyme Activation - drug effects Ethylenediamines - chemistry Heme - chemistry Heme - pharmacology Heme Oxygenase-1 - metabolism Hemopexin - chemistry Hemopexin - pharmacology Hydrogen-Ion Concentration Iron Life Sciences Medicine/Public Health Membrane Proteins - metabolism Metallothionein - metabolism Metallothioneins Mice Microbiology Molecular Chaperones - metabolism Pharmacology/Toxicology Plant Physiology Proteins
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