Crosslinked a,b-Polyasparthydrazide Micromatrices for Controlled Release of Anticancer Drugs

Crosslinked a,b-Polyasparthydrazide Micromatrices for Controlled Release of Anticancer Drugs

The preparation of new hydrogels by the reaction of a,b- polyasparthydrazide and glutaraldehyde is reported. A different crosslinking degree was obtained by varying the ratio crosslinking agent/polymer which influenced the swelling behavior of the gel. 5-Fluorouracil, was incorporated into the matri...

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Veröffentlicht in:Journal of bioactive and compatible polymers 1995-01, Vol.10 (1), p.28-40
Hauptverfasser: Giammona, Gaetano, Pitarresi, Giovanna, Carlisi, Bianca, Cavallaro, Gennara
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container_end_page 40
container_issue 1
container_start_page 28
container_title Journal of bioactive and compatible polymers
container_volume 10
creator Giammona, Gaetano
Pitarresi, Giovanna
Carlisi, Bianca
Cavallaro, Gennara
description The preparation of new hydrogels by the reaction of a,b- polyasparthydrazide and glutaraldehyde is reported. A different crosslinking degree was obtained by varying the ratio crosslinking agent/polymer which influenced the swelling behavior of the gel. 5-Fluorouracil, was incorporated into the matrices during the crosslinking reaction and in vitro release studies were performed in simulated gastric juice (pH 1.1) and pH 7.4 buffer solution. The hydrogels prepared were chemically stable in the dissolution media. The observed data show the potential application of these new matrices for peroral administration of anticancer agents.
doi_str_mv 10.1177/088391159501000104
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title Crosslinked a,b-Polyasparthydrazide Micromatrices for Controlled Release of Anticancer Drugs
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