Toxicodynamics of subacute co-exposure to groundwater contaminant arsenic and analgesic–antipyretic drug acetaminophen in rats

Arsenic is an environmental contaminant, while acetaminophen is an extensively used nonsteroidal analgesic–antipyretic drug. We evaluated whether subacute co-exposure to arsenic and acetaminophen would produce more toxicity than that caused by exposure to either of the xenobiotics in rats. Toxicity...

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Veröffentlicht in:	Ecotoxicology and environmental safety 2010, Vol.73 (1), p.94-100
Hauptverfasser:	Manimaran, Ayyasamy, Nath Sarkar, Souvendra, Sankar, Palanisamy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - toxicity Analgesics, Non-Narcotic - toxicity Animals Arsenic Arsenic - toxicity Body weight Body Weight - drug effects Co-exposure Contaminants Cytochrome P-450 Enzyme System - metabolism Drugs Eating - drug effects Enzymes Glutathione - analysis Lipid Peroxidation Lipids Liver Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Oxidative Stress Rats Rats, Wistar Superoxide Dismutase - metabolism Toxicity Water Pollutants, Chemical - toxicity
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