Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements

Bordetella bacteriophages generate diversity in a gene that specifies host tropism. This microevolutionary adaptation is produced by a genetic element that combines the basic retroelement life cycle of transcription, reverse transcription and integration with site-directed, adenine-specific mutagene...

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Veröffentlicht in:	Nature 2004-09, Vol.431 (7007), p.476-481
Hauptverfasser:	Miller, Jeff F, Doulatov, Sergei, Hodes, Asher, Dai, Lixin, Mandhana, Neeraj, Liu, Minghsun, Deora, Rajendar, Simons, Robert W, Zimmerly, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Bacteria Bacteriology Bacteriophages - enzymology Bacteriophages - genetics Bacteriophages - physiology Base Sequence Biological and medical sciences Biological Evolution Bordetella - classification Bordetella - virology Computational Biology Fundamental and applied biological sciences. Psychology Genes, Viral - genetics Genetic diversity Genetic Variation - genetics Genome, Viral Genomics Host-Parasite Interactions Microbiology Mutagenesis - genetics Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Phylogeny Polymorphism, Genetic - genetics Retroelements - genetics Retroelements - physiology RNA-Directed DNA Polymerase - metabolism Selection, Genetic Species Specificity Transcription, Genetic - genetics
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