Three-Dimensional Structure of Cholera Toxin Penetrating a Lipid Membrane

Two-dimensional crystals of cholera toxin bound to receptors in a lipid membrane give diffraction extending to 15 Å resolution. Three-dimensional structure determination reveals a ring of five B subunits on the membrane surface, with one-third of the A subunit occupying the center of the ring. The r...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1988-03, Vol.239 (4845), p.1272-1276
Hauptverfasser:	Ribi, Hans O., Ludwig, David S., Mercer, K. Lynne, Schoolnik, Gary K., Kornberg, Roger D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Cell membranes Cholera Cholera Toxin Crystal lattices Crystallography Crystals Density Disease Electron microscopy Fundamental and applied biological sciences. Psychology G(M1) Ganglioside Lipids Liposomes Macromolecular Substances Medical research Membranes (Biology) Microbial toxins Microscopy, Electron Models, Molecular Molecular biophysics Molecules Oligomers Phosphatidylethanolamines Protein Conformation Structure in molecular biology Toxins Tridimensional structure Vibrio cholerae
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