The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

Zinc is present in presynaptic nerve terminals throughout the mammalian central nervous system and likely serves as an endogenous signaling substance. However, excessive exposure to extracellular zinc can damage central neurons. After transient forebrain ischemia in rats, chelatable zinc accumulated...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-05, Vol.272 (5264), p.1013-1016
Hauptverfasser:	Koh, Jae-Young, Suh, Sang W., Gwag, Byoung J., He, Yong Y., Hsu, Chung Y., Choi, Dennis W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines Amygdala Animals Biological and medical sciences Brain Brain - metabolism Brain - pathology Cell Death Chelating Agents - pharmacology Chelation Cytology Degeneration Dithizone - pharmacology Edetic Acid - pharmacology Fluorescence Fluorescent Dyes Forebrain Hippocampus Hippocampus - metabolism Hippocampus - pathology Ischemia Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Mammals Medical sciences Microscopy, Fluorescence Nerve Degeneration Nervous system Neurology Neurons Neurons - metabolism Neurons - pathology Neuroscience Presynaptic Terminals - metabolism Pyramidal Cells - metabolism Pyramidal Cells - pathology Rats Tosyl Compounds Vascular diseases and vascular malformations of the nervous system Zinc Zinc (Nutrient) Zinc - metabolism Zinc in the body
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