Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail

The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines. Here, we present structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modificatio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-03, Vol.295 (5562), p.2080-2083
Hauptverfasser:	Jacobs, Steven A., Khorasanizadeh, Sepideh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Amino acids Atomic interactions Biochemistry Biological and medical sciences chromodomains Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Crystallography, X-Ray DNA Drosophila Drosophila Proteins - chemistry Drosophila Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Genetic mutation Genetics Genomes Genomics Histones Histones - chemistry Histones - genetics Histones - metabolism Hydrogen Bonding Insects Lysine - analogs & derivatives Lysine - chemistry Lysine - metabolism Methylation Models, Molecular Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis Mutation Peptides - chemistry Peptides - metabolism Plant cells Point Mutation Protein Binding Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Proteins Sequence Alignment
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!