Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting

THE signal-recognition particle (SRP) is important for the targeting of many secretory and membrane proteins to the endoplasmic reticulum (ER). Targeting is regulated by three GTPases, the 54K subunit of SRP (SRP54), and the α- and β-subunits of the SRP receptor 1 . When a signal sequence emerges fr...

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Veröffentlicht in:	Nature (London) 1996-05, Vol.381 (6579), p.248-251
Hauptverfasser:	Bacher, Gerald, Lütcke, Henrich, Jungnickel, Berit, Rapoport, Tom A., Dobberstein, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Biological Transport - radiation effects Cell physiology Endoplasmic Reticulum - metabolism Fundamental and applied biological sciences. Psychology GTP Phosphohydrolases - metabolism Guanosine Triphosphate - metabolism Humanities and Social Sciences Hydrolysis letter Membrane and intracellular transports Molecular and cellular biology Molecular biology Molecular Sequence Data multidisciplinary Mutagenesis, Site-Directed Oligodeoxyribonucleotides Peptides Prolactin - metabolism Protein Binding Protein Precursors - metabolism Protein Sorting Signals - metabolism Proteins Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Peptide - metabolism Ribosomes - metabolism Science Science (multidisciplinary) Signal Recognition Particle - metabolism Translocation Ultraviolet Rays
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