Regulation of Proenkephalin by Fos and Jun

Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site. Although this complex has been proposed to function as a transcriptional regulator in neurons, no specific target gene has yet been identified. Proenkephalin mRNA increased in...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1989-12, Vol.246 (4937), p.1622-1625
Hauptverfasser:	Sonnenberg, June L., Rauscher, Frank J., Morgan, James I., Curran, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Animals Automobiles Base Sequence Biological and medical sciences Brain Brain - metabolism Cell Line Census agricultural regions DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Enkephalins - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Genes Genetic regulation Genetic transcription Genetics Hippocampus Hippocampus - metabolism Immediate early genes Medical research Messenger RNA Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Neurons Nucleotide sequence Plasmids Promoter Regions, Genetic Protein Precursors - genetics Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-jun Proto-Oncogenes rev genes RNA RNA, Messenger - genetics Seizures Teratoma Transcription (Genetics) Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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