Application of direct fluid flow oscillations to improve mixing in microbioreactors
This article describes an active mixing method for a microbioreactor that was designed, simulated, tested, and successfully implemented. By applying a varying pressure to a microchannel looping tangentially into a cylindrical microreactor an oscillating fluid flow was shown to occur. Such an oscilla...
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| Veröffentlicht in: | AIChE journal 2009-10, Vol.55 (10), p.2725-2736 |
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| creator | Li, X van der Steen, G van Dedem, G.W.K van der Wielen, L.A.M van Leeuwen, M van Gulik, W.M Heijnen, J.J Ottens, M Krommenhoek, E.E Gardeniers, J.G.E van den Berg, A |
| description | This article describes an active mixing method for a microbioreactor that was designed, simulated, tested, and successfully implemented. By applying a varying pressure to a microchannel looping tangentially into a cylindrical microreactor an oscillating fluid flow was shown to occur. Such an oscillating fluid flow improved mixing, both by diffusion and convection. The oscillating fluid flow has a large impact on the ratio between the diffusion domain and the convection domain. A good match was obtained between experimental mixing results, computational fluid dynamics simulation results and the results of a simplified mixing model thus demonstrating the potential of simulation on improving the design of microreactors. © 2009 American Institute of Chemical Engineers AIChE J, 2009 |
| doi_str_mv | 10.1002/aic.11880 |
| format | Article |
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By applying a varying pressure to a microchannel looping tangentially into a cylindrical microreactor an oscillating fluid flow was shown to occur. Such an oscillating fluid flow improved mixing, both by diffusion and convection. The oscillating fluid flow has a large impact on the ratio between the diffusion domain and the convection domain. A good match was obtained between experimental mixing results, computational fluid dynamics simulation results and the results of a simplified mixing model thus demonstrating the potential of simulation on improving the design of microreactors. © 2009 American Institute of Chemical Engineers AIChE J, 2009</description><subject>Analytical chemistry</subject><subject>Applied sciences</subject><subject>Chemical engineering</subject><subject>computational fluid dynamics (CFD)</subject><subject>Diffusion</subject><subject>Exact sciences and technology</subject><subject>Fluid dynamics</subject><subject>Membrane reactors</subject><subject>microbioreactor</subject><subject>microfluidics</subject><subject>micromixing</subject><subject>oscillations</subject><subject>Reactors</subject><subject>Simulation</subject><issn>0001-1541</issn><issn>1547-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkVFLHDEUhUOp0K32ob_AQajQh9HcZDLJPK6LtcJWW6z4GO5kEonOTtZktuq_b-pYHwpCX5Lc8J3DOVxCPgI9AErZIXpzAKAUfUNmICpZioaKt2RGKYUyf8A78j6lmzwxqdiMXMzX694bHH0YiuCKzkdrxsL1G9_lM9wXIRnf909AKsZQ-NU6hl-2WPkHP1wXfsgvE0PrQ7RoxhDTDtly2Cf74fneJpdfjn8uvpbL85PTxXxZmkoJWnKoueyc6SqunHTGceu6yqCEtlUosUNLVcOocAzrVtZCoGsch7Zrueuw4ttkf_LNge42No165ZOxOexgwyZpXoNoOP8PUFBWSwoZ3PsHvAmbOOQSGpqmqlm2zNDnCcqtU4rW6XX0K4yPGqj-swSdl6CflpDZT8-GmAz2LuJgfHoRMGhEwxjL3OHE3fvePr5uqOeni7_O5aTwabQPLwqMt7qWXAp9dXaif5wJsfz2HfRR5ncn3mHQeB1zissLljtTqBVjCvhvzaeujA</recordid><startdate>200910</startdate><enddate>200910</enddate><creator>Li, X</creator><creator>van der Steen, G</creator><creator>van Dedem, G.W.K</creator><creator>van der Wielen, L.A.M</creator><creator>van Leeuwen, M</creator><creator>van Gulik, W.M</creator><creator>Heijnen, J.J</creator><creator>Ottens, M</creator><creator>Krommenhoek, E.E</creator><creator>Gardeniers, J.G.E</creator><creator>van den Berg, A</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Institute of Chemical Engineers</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U5</scope><scope>8FD</scope><scope>C1K</scope><scope>L7M</scope><scope>SOI</scope></search><sort><creationdate>200910</creationdate><title>Application of direct fluid flow oscillations to improve mixing in microbioreactors</title><author>Li, X ; van der Steen, G ; van Dedem, G.W.K ; van der Wielen, L.A.M ; van Leeuwen, M ; van Gulik, W.M ; Heijnen, J.J ; Ottens, M ; Krommenhoek, E.E ; Gardeniers, J.G.E ; van den Berg, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4850-31637dfcd438f7fcf3efd4ca71bb8a7adae089205f2a6b7655af9f31bdb3fda43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analytical chemistry</topic><topic>Applied sciences</topic><topic>Chemical engineering</topic><topic>computational fluid dynamics (CFD)</topic><topic>Diffusion</topic><topic>Exact sciences and technology</topic><topic>Fluid dynamics</topic><topic>Membrane reactors</topic><topic>microbioreactor</topic><topic>microfluidics</topic><topic>micromixing</topic><topic>oscillations</topic><topic>Reactors</topic><topic>Simulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, X</creatorcontrib><creatorcontrib>van der Steen, G</creatorcontrib><creatorcontrib>van Dedem, G.W.K</creatorcontrib><creatorcontrib>van der Wielen, L.A.M</creatorcontrib><creatorcontrib>van Leeuwen, M</creatorcontrib><creatorcontrib>van Gulik, W.M</creatorcontrib><creatorcontrib>Heijnen, J.J</creatorcontrib><creatorcontrib>Ottens, M</creatorcontrib><creatorcontrib>Krommenhoek, E.E</creatorcontrib><creatorcontrib>Gardeniers, J.G.E</creatorcontrib><creatorcontrib>van den Berg, A</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Environment Abstracts</collection><jtitle>AIChE journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, X</au><au>van der Steen, G</au><au>van Dedem, G.W.K</au><au>van der Wielen, L.A.M</au><au>van Leeuwen, M</au><au>van Gulik, W.M</au><au>Heijnen, J.J</au><au>Ottens, M</au><au>Krommenhoek, E.E</au><au>Gardeniers, J.G.E</au><au>van den Berg, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of direct fluid flow oscillations to improve mixing in microbioreactors</atitle><jtitle>AIChE journal</jtitle><addtitle>AIChE J</addtitle><date>2009-10</date><risdate>2009</risdate><volume>55</volume><issue>10</issue><spage>2725</spage><epage>2736</epage><pages>2725-2736</pages><issn>0001-1541</issn><eissn>1547-5905</eissn><coden>AICEAC</coden><abstract>This article describes an active mixing method for a microbioreactor that was designed, simulated, tested, and successfully implemented. 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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Analytical chemistry Applied sciences Chemical engineering computational fluid dynamics (CFD) Diffusion Exact sciences and technology Fluid dynamics Membrane reactors microbioreactor microfluidics micromixing oscillations Reactors Simulation |
| title | Application of direct fluid flow oscillations to improve mixing in microbioreactors |
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