Polyurethane scaffold formation via a combination of salt leaching and thermally induced phase separation
Porous scaffolds have been made from twopolyurethanes based on thermally induced phase separation of polymer dissolved in a DMSO/water mixture in combination with salt leaching. It is possible to obtain very porous foams with a very high interconnectivity. A major advantage of this method is that va...
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| Veröffentlicht in: | Journal of Biomedical Materials Research Part B 2008-12, Vol.87A (4), p.921-932 |
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| container_title | Journal of Biomedical Materials Research Part B |
| container_volume | 87A |
| creator | Heijkants, R. G. J. C. van Calck, R. V. van Tienen, T. G. de Groot, J. H. Pennings, A. J. Buma, P. Veth, R. P. H. Schouten, A. J. |
| description | Porous scaffolds have been made from twopolyurethanes based on thermally induced phase separation of polymer dissolved in a DMSO/water mixture in combination with salt leaching. It is possible to obtain very porous foams with a very high interconnectivity. A major advantage of this method is that variables like porosity, pore size, and interconnectivity can be independently adjusted with the absence of toxic materials in the production process. The obtained compression moduli were between 200 kPa and 1 MPa with a variation in porosity between 76 and 84%. Currently the biological and medical aspects are under evaluation. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008 |
| doi_str_mv | 10.1002/jbm.a.31829 |
| format | Article |
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J Biomed Mater Res, 2008</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.a.31829</identifier><identifier>PMID: 18228268</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biocompatible Materials - chemistry ; degradable ; Dimethyl Sulfoxide - chemistry ; Materials Testing ; meniscus ; polyurethane ; Polyurethanes - chemistry ; Porosity ; Salts - chemistry ; scaffold ; Solvents - chemistry ; Spectroscopy, Fourier Transform Infrared ; Surface Properties ; Temperature ; thermally induced phase separation ; Tissue Engineering - methods ; Tissue Scaffolds</subject><ispartof>Journal of Biomedical Materials Research Part B, 2008-12, Vol.87A (4), p.921-932</ispartof><rights>Copyright © 2008 Wiley Periodicals, Inc.</rights><rights>2008 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5019-dc9e465696a4b168f8dd1f2be565b4511c8f3b6c82e437a799898f36fafae8e83</citedby><cites>FETCH-LOGICAL-c5019-dc9e465696a4b168f8dd1f2be565b4511c8f3b6c82e437a799898f36fafae8e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.a.31829$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.a.31829$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18228268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heijkants, R. 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J Biomed Mater Res, 2008</description><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>degradable</subject><subject>Dimethyl Sulfoxide - chemistry</subject><subject>Materials Testing</subject><subject>meniscus</subject><subject>polyurethane</subject><subject>Polyurethanes - chemistry</subject><subject>Porosity</subject><subject>Salts - chemistry</subject><subject>scaffold</subject><subject>Solvents - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Surface Properties</subject><subject>Temperature</subject><subject>thermally induced phase separation</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQRi0EoqVw4o584oKy2E7s2EdYwRZUoIciVlysiWOzLk682All_z1us8CN04xG73vSfAg9pWRFCWEvr7thBauaSqbuoVPKOasaJfj9271RVc2UOEGPcr4usCCcPUQnhWWSCXmK_GUMhznZaQejxdmAczH02MU0wOTjiH96wIBNHDo_LpfocIYw4WDB7Pz4DcPY42lnSyKEA_ZjPxvb4_0OcjHaPaS73GP0wEHI9slxnqHPb99crc-ri0-bd-tXF5XhhKqqN8o2ggsloOmokE72PXWss1zwruGUGunqThjJbFO30ColVbkIBw6stLI-Q88X7z7FH7PNkx58NjaE8mCcs64FobwlpIAvFtCkmHOyTu-THyAdNCX6tlldmtWg75ot9LOjdu4G2_9jj1UWgC7AjQ_28D-Xfv_6wx9ptWR8nuyvvxlI37Vo65brLx83mm6366vLzVe9rX8D2ZmVNw</recordid><startdate>20081215</startdate><enddate>20081215</enddate><creator>Heijkants, R. 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| subjects | Animals Biocompatible Materials - chemistry degradable Dimethyl Sulfoxide - chemistry Materials Testing meniscus polyurethane Polyurethanes - chemistry Porosity Salts - chemistry scaffold Solvents - chemistry Spectroscopy, Fourier Transform Infrared Surface Properties Temperature thermally induced phase separation Tissue Engineering - methods Tissue Scaffolds |
| title | Polyurethane scaffold formation via a combination of salt leaching and thermally induced phase separation |
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