Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study

The present study describes the production of hyaluronan based porous microparticles by a semi-continuous gas anti-solvent (GAS) precipitation process to be used as a growth factor delivery system for in vivo treatment of ulcers. Operative process conditions, such as pressure, nozzle diameter and HY...

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Veröffentlicht in:	Journal of materials science. Materials in medicine 2009, Vol.20 (1), p.235-247
Hauptverfasser:	Zavan, B., Vindigni, V., Vezzù, K., Zorzato, G., Luni, C., Abatangelo, G., Elvassore, N., Cortivo, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Biocompatible Materials - chemistry Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Ceramics Chemistry and Materials Science Composites Drug delivery systems Glass Growth Substances - administration & dosage Hyaluronic Acid - chemistry Male Materials Science Materials Testing Microscopy, Electron, Scanning Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Nanoparticles - ultrastructure Nanotechnology - instrumentation Natural Materials Platelet-Derived Growth Factor - administration & dosage Polymer Sciences Porous materials Rats Rats, Wistar Regenerative Medicine/Tissue Engineering Skin Ulcer - drug therapy Skin Ulcer - pathology Skin Ulcer - therapy Surfaces and Interfaces Thin Films Tissue engineering Tissue Scaffolds Transforming Growth Factor beta - administration & dosage Ulcers Water - chemistry Wound healing Wound Healing - drug effects
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