Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study
The present study describes the production of hyaluronan based porous microparticles by a semi-continuous gas anti-solvent (GAS) precipitation process to be used as a growth factor delivery system for in vivo treatment of ulcers. Operative process conditions, such as pressure, nozzle diameter and HY...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2009, Vol.20 (1), p.235-247 |
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| creator | Zavan, B. Vindigni, V. Vezzù, K. Zorzato, G. Luni, C. Abatangelo, G. Elvassore, N. Cortivo, R. |
| description | The present study describes the production of hyaluronan based porous microparticles by a semi-continuous gas anti-solvent (GAS) precipitation process to be used as a growth factor delivery system for in vivo treatment of ulcers. Operative process conditions, such as pressure, nozzle diameter and HYAFF11
®
solution concentrations, were adjusted to optimize particle production in terms of morphology and size. Scanning electron microscopy (SEM) and light scattering demonstrated that porous nano-structured particles with a size of 300 and 900 nm had a high specific surface suitable for absorption of growth factors from the aqueous environment within the polymeric matrix. Water acted as a plasticizer, enhancing growth factor absorption. Water contents within the HYAFF11
®
matrix were analyzed by differential scanning calorimetry (DSC). The absorption process was developed using fluorescence dyes and growth factors. Immunohistochemical analysis confirmed the high efficiency of absorption of growth factor and a mathematical model was generated to quantify and qualify the in vitro kinetics of growth factor release within the polymeric matrix. In vivo experiments were performed with the aim to optimize timed and focal release of PDGF to promote optimal tissue repair and regeneration of full-thickness wounds. |
| doi_str_mv | 10.1007/s10856-008-3566-3 |
| format | Article |
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®
solution concentrations, were adjusted to optimize particle production in terms of morphology and size. Scanning electron microscopy (SEM) and light scattering demonstrated that porous nano-structured particles with a size of 300 and 900 nm had a high specific surface suitable for absorption of growth factors from the aqueous environment within the polymeric matrix. Water acted as a plasticizer, enhancing growth factor absorption. Water contents within the HYAFF11
®
matrix were analyzed by differential scanning calorimetry (DSC). The absorption process was developed using fluorescence dyes and growth factors. Immunohistochemical analysis confirmed the high efficiency of absorption of growth factor and a mathematical model was generated to quantify and qualify the in vitro kinetics of growth factor release within the polymeric matrix. In vivo experiments were performed with the aim to optimize timed and focal release of PDGF to promote optimal tissue repair and regeneration of full-thickness wounds.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-008-3566-3</identifier><identifier>PMID: 18758917</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Absorption ; Animals ; Biocompatible Materials - chemistry ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Ceramics ; Chemistry and Materials Science ; Composites ; Drug delivery systems ; Glass ; Growth Substances - administration & dosage ; Hyaluronic Acid - chemistry ; Male ; Materials Science ; Materials Testing ; Microscopy, Electron, Scanning ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanoparticles - ultrastructure ; Nanotechnology - instrumentation ; Natural Materials ; Platelet-Derived Growth Factor - administration & dosage ; Polymer Sciences ; Porous materials ; Rats ; Rats, Wistar ; Regenerative Medicine/Tissue Engineering ; Skin Ulcer - drug therapy ; Skin Ulcer - pathology ; Skin Ulcer - therapy ; Surfaces and Interfaces ; Thin Films ; Tissue engineering ; Tissue Scaffolds ; Transforming Growth Factor beta - administration & dosage ; Ulcers ; Water - chemistry ; Wound healing ; Wound Healing - drug effects</subject><ispartof>Journal of materials science. Materials in medicine, 2009, Vol.20 (1), p.235-247</ispartof><rights>The Author(s) 2008</rights><rights>Springer Science+Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-707874d779b12b0bd14b27ce5f98c3caab4f94cbaad181f83ff01a2be232e6f03</citedby><cites>FETCH-LOGICAL-c443t-707874d779b12b0bd14b27ce5f98c3caab4f94cbaad181f83ff01a2be232e6f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-008-3566-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-008-3566-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18758917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zavan, B.</creatorcontrib><creatorcontrib>Vindigni, V.</creatorcontrib><creatorcontrib>Vezzù, K.</creatorcontrib><creatorcontrib>Zorzato, G.</creatorcontrib><creatorcontrib>Luni, C.</creatorcontrib><creatorcontrib>Abatangelo, G.</creatorcontrib><creatorcontrib>Elvassore, N.</creatorcontrib><creatorcontrib>Cortivo, R.</creatorcontrib><title>Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>The present study describes the production of hyaluronan based porous microparticles by a semi-continuous gas anti-solvent (GAS) precipitation process to be used as a growth factor delivery system for in vivo treatment of ulcers. Operative process conditions, such as pressure, nozzle diameter and HYAFF11
®
solution concentrations, were adjusted to optimize particle production in terms of morphology and size. Scanning electron microscopy (SEM) and light scattering demonstrated that porous nano-structured particles with a size of 300 and 900 nm had a high specific surface suitable for absorption of growth factors from the aqueous environment within the polymeric matrix. Water acted as a plasticizer, enhancing growth factor absorption. Water contents within the HYAFF11
®
matrix were analyzed by differential scanning calorimetry (DSC). The absorption process was developed using fluorescence dyes and growth factors. Immunohistochemical analysis confirmed the high efficiency of absorption of growth factor and a mathematical model was generated to quantify and qualify the in vitro kinetics of growth factor release within the polymeric matrix. In vivo experiments were performed with the aim to optimize timed and focal release of PDGF to promote optimal tissue repair and regeneration of full-thickness wounds.</description><subject>Absorption</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Drug delivery systems</subject><subject>Glass</subject><subject>Growth Substances - administration & dosage</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Male</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - therapeutic use</subject><subject>Nanoparticles - ultrastructure</subject><subject>Nanotechnology - instrumentation</subject><subject>Natural Materials</subject><subject>Platelet-Derived Growth Factor - administration & dosage</subject><subject>Polymer Sciences</subject><subject>Porous materials</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Skin Ulcer - drug therapy</subject><subject>Skin Ulcer - pathology</subject><subject>Skin Ulcer - therapy</subject><subject>Surfaces and Interfaces</subject><subject>Thin Films</subject><subject>Tissue engineering</subject><subject>Tissue Scaffolds</subject><subject>Transforming Growth Factor beta - administration & dosage</subject><subject>Ulcers</subject><subject>Water - chemistry</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFrHCEUx6W0NNu0HyCXID3kZqujjk5vIaRNIdBLexZ1ntkJ7jhVh7Dky9ewCwuBnh74fu_v0x9CF4x-YZSqr4VRLXtCqSZc9j3hb9CGScWJ0Fy_RRs6SEWE5PQMfSjlkVIqBinfozOmldQDUxv0fLe3cc1ptjN2tsCIl5TTWnA7SGSxuU4-QsEw58lvW_tpqlv8kNNTK8H6mnLBIWVct4BrBlt3MFecAl6jh1y-YYuXaD24RHyaa04xtpRS13H_Eb0LNhb4dKzn6M_32983d-T-14-fN9f3xAvBK1FUaSVGpQbHOkfdyITrlAcZBu25t9aJMAjvrB2ZZkHzECiznYOOd9AHys_R1SF3yenvCqWa3VQ8xGhnaE81XA49FXpo4OdX4GNa89x2M7pj7at73TeIHSCfUykZglnytLN5bxg1L1rMQYtpWsyLFsPbzOUxeHU7GE8TRw8N6A5Aaa35AfLp5v-n_gMQMZrE</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Zavan, B.</creator><creator>Vindigni, V.</creator><creator>Vezzù, K.</creator><creator>Zorzato, G.</creator><creator>Luni, C.</creator><creator>Abatangelo, G.</creator><creator>Elvassore, N.</creator><creator>Cortivo, R.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0W</scope></search><sort><creationdate>2009</creationdate><title>Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study</title><author>Zavan, B. ; Vindigni, V. ; Vezzù, K. ; Zorzato, G. ; Luni, C. ; Abatangelo, G. ; Elvassore, N. ; Cortivo, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-707874d779b12b0bd14b27ce5f98c3caab4f94cbaad181f83ff01a2be232e6f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Biocompatible Materials - 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zavan, B.</au><au>Vindigni, V.</au><au>Vezzù, K.</au><au>Zorzato, G.</au><au>Luni, C.</au><au>Abatangelo, G.</au><au>Elvassore, N.</au><au>Cortivo, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study</atitle><jtitle>Journal of materials science. 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®
solution concentrations, were adjusted to optimize particle production in terms of morphology and size. Scanning electron microscopy (SEM) and light scattering demonstrated that porous nano-structured particles with a size of 300 and 900 nm had a high specific surface suitable for absorption of growth factors from the aqueous environment within the polymeric matrix. Water acted as a plasticizer, enhancing growth factor absorption. Water contents within the HYAFF11
®
matrix were analyzed by differential scanning calorimetry (DSC). The absorption process was developed using fluorescence dyes and growth factors. Immunohistochemical analysis confirmed the high efficiency of absorption of growth factor and a mathematical model was generated to quantify and qualify the in vitro kinetics of growth factor release within the polymeric matrix. In vivo experiments were performed with the aim to optimize timed and focal release of PDGF to promote optimal tissue repair and regeneration of full-thickness wounds.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18758917</pmid><doi>10.1007/s10856-008-3566-3</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of materials science. Materials in medicine, 2009, Vol.20 (1), p.235-247 |
| issn | 0957-4530 1573-4838 |
| language | eng |
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| subjects | Absorption Animals Biocompatible Materials - chemistry Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Ceramics Chemistry and Materials Science Composites Drug delivery systems Glass Growth Substances - administration & dosage Hyaluronic Acid - chemistry Male Materials Science Materials Testing Microscopy, Electron, Scanning Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Nanoparticles - ultrastructure Nanotechnology - instrumentation Natural Materials Platelet-Derived Growth Factor - administration & dosage Polymer Sciences Porous materials Rats Rats, Wistar Regenerative Medicine/Tissue Engineering Skin Ulcer - drug therapy Skin Ulcer - pathology Skin Ulcer - therapy Surfaces and Interfaces Thin Films Tissue engineering Tissue Scaffolds Transforming Growth Factor beta - administration & dosage Ulcers Water - chemistry Wound healing Wound Healing - drug effects |
| title | Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study |
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