Dioscorea improves the morphometric and mechanical properties of bone in ovariectomised rats
BACKGROUND: The aim of this work was to determine the effects of oral administration of dioscorea on the morphometric and mechanical properties of the femur in ovariectomised (OVX) rats. Female Wistar rats that had undergone surgery for ovariectomy were used as a model of menopause and osteoporosis....
Gespeichert in:
| Veröffentlicht in: | Journal of the science of food and agriculture 2008-12, Vol.88 (15), p.2700-2706 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2706 |
|---|---|
| container_issue | 15 |
| container_start_page | 2700 |
| container_title | Journal of the science of food and agriculture |
| container_volume | 88 |
| creator | Chen, Jian-Horng Wu, James Shih-Shyn Lin, Hsiao-Che Wu, Shey-Lin Wang, Wen-Fu Huang, Shu-Kuei Ho, Ying-Jui |
| description | BACKGROUND: The aim of this work was to determine the effects of oral administration of dioscorea on the morphometric and mechanical properties of the femur in ovariectomised (OVX) rats. Female Wistar rats that had undergone surgery for ovariectomy were used as a model of menopause and osteoporosis. Four weeks after surgery the animals were given oral dioscorea (0, 250, 750 or 1500 mg kg−1 day−1) for 27 days, then the porosity, mineral fraction, stiffness and toughness of the femur and the ultimate force needed to break the femur were measured.
RESULTS: Ovariectomy resulted in an increase in the total volume, dry weight and porosity but a decrease in the mineral fraction of femora. Subsequent chronic administration of dioscorea reversed the effect on porosity and increased the ultimate force of the femur in OVX rats but did not affect the bone properties of sham‐operated rats.
CONCLUSION: These results suggest that chronic administration of dioscorea may enhance bone strength and provide insight into the role of dioscorea in bone remodeling and osteoporosis during the menopause. However, the benefit is not clear for the reproductive female. Copyright © 2008 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.3396 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_35749339</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19509801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4266-bf33a66cb826ce7b119565f79864df2e1659f50057ecc103bacc658d32bec91a3</originalsourceid><addsrcrecordid>eNqFkU9vEzEQxS0EEqHlwDewkEDisO3YXnvXx6qhgaoCidL2gmR5nbHisLtO7U2h3x5HiXpAQpzmML_35s8j5A2DEwbAT9fZ2xMhtHpGZgx0UwEweE5mpccryWr-krzKeQ0AWis1Iz_mIWYXE1oahk2KD5jptEI6xLRZxQGnFBy145IO6FZ2DM72tGAbTFMoaPS0iyPSMNL4YFNAN8UhZFzSZKd8TF5422d8fahH5Obi4_fzT9XV18Xn87OrytVcqarzQlilXNdy5bDpGNNSSd_oVtVLz5Epqb0EkA06x0B01jkl26XgHTrNrDgi7_e-ZbP7LebJlB0c9r0dMW6zEbKpdXnKf8EyGHQLrIBv_wLXcZvGcoThnKumqRUU6MMecinmnNCbTQqDTY-GgdmlYXZpmF0ahX13MLS5_NAnO7qQnwQcWtbKdsed7rlfocfHfxuay-uLs4NztVeEPOHvJ4VNP41qRCPN3ZeFuf4m53e3i7lpxR9ZAajV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222677460</pqid></control><display><type>article</type><title>Dioscorea improves the morphometric and mechanical properties of bone in ovariectomised rats</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Chen, Jian-Horng ; Wu, James Shih-Shyn ; Lin, Hsiao-Che ; Wu, Shey-Lin ; Wang, Wen-Fu ; Huang, Shu-Kuei ; Ho, Ying-Jui</creator><creatorcontrib>Chen, Jian-Horng ; Wu, James Shih-Shyn ; Lin, Hsiao-Che ; Wu, Shey-Lin ; Wang, Wen-Fu ; Huang, Shu-Kuei ; Ho, Ying-Jui</creatorcontrib><description>BACKGROUND: The aim of this work was to determine the effects of oral administration of dioscorea on the morphometric and mechanical properties of the femur in ovariectomised (OVX) rats. Female Wistar rats that had undergone surgery for ovariectomy were used as a model of menopause and osteoporosis. Four weeks after surgery the animals were given oral dioscorea (0, 250, 750 or 1500 mg kg−1 day−1) for 27 days, then the porosity, mineral fraction, stiffness and toughness of the femur and the ultimate force needed to break the femur were measured.
RESULTS: Ovariectomy resulted in an increase in the total volume, dry weight and porosity but a decrease in the mineral fraction of femora. Subsequent chronic administration of dioscorea reversed the effect on porosity and increased the ultimate force of the femur in OVX rats but did not affect the bone properties of sham‐operated rats.
CONCLUSION: These results suggest that chronic administration of dioscorea may enhance bone strength and provide insight into the role of dioscorea in bone remodeling and osteoporosis during the menopause. However, the benefit is not clear for the reproductive female. Copyright © 2008 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.3396</identifier><identifier>CODEN: JSFAAE</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; bone properties ; Bones ; Dioscorea ; Effects ; Flowers & plants ; Food industries ; Fundamental and applied biological sciences. Psychology ; Mechanical properties ; osteoporosis ; ovariectomy ; Rodents</subject><ispartof>Journal of the science of food and agriculture, 2008-12, Vol.88 (15), p.2700-2706</ispartof><rights>Copyright © 2008 Society of Chemical Industry</rights><rights>2008 INIST-CNRS</rights><rights>Copyright John Wiley and Sons, Limited Dec 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4266-bf33a66cb826ce7b119565f79864df2e1659f50057ecc103bacc658d32bec91a3</citedby><cites>FETCH-LOGICAL-c4266-bf33a66cb826ce7b119565f79864df2e1659f50057ecc103bacc658d32bec91a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.3396$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.3396$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20818586$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jian-Horng</creatorcontrib><creatorcontrib>Wu, James Shih-Shyn</creatorcontrib><creatorcontrib>Lin, Hsiao-Che</creatorcontrib><creatorcontrib>Wu, Shey-Lin</creatorcontrib><creatorcontrib>Wang, Wen-Fu</creatorcontrib><creatorcontrib>Huang, Shu-Kuei</creatorcontrib><creatorcontrib>Ho, Ying-Jui</creatorcontrib><title>Dioscorea improves the morphometric and mechanical properties of bone in ovariectomised rats</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>BACKGROUND: The aim of this work was to determine the effects of oral administration of dioscorea on the morphometric and mechanical properties of the femur in ovariectomised (OVX) rats. Female Wistar rats that had undergone surgery for ovariectomy were used as a model of menopause and osteoporosis. Four weeks after surgery the animals were given oral dioscorea (0, 250, 750 or 1500 mg kg−1 day−1) for 27 days, then the porosity, mineral fraction, stiffness and toughness of the femur and the ultimate force needed to break the femur were measured.
RESULTS: Ovariectomy resulted in an increase in the total volume, dry weight and porosity but a decrease in the mineral fraction of femora. Subsequent chronic administration of dioscorea reversed the effect on porosity and increased the ultimate force of the femur in OVX rats but did not affect the bone properties of sham‐operated rats.
CONCLUSION: These results suggest that chronic administration of dioscorea may enhance bone strength and provide insight into the role of dioscorea in bone remodeling and osteoporosis during the menopause. However, the benefit is not clear for the reproductive female. Copyright © 2008 Society of Chemical Industry</description><subject>Biological and medical sciences</subject><subject>bone properties</subject><subject>Bones</subject><subject>Dioscorea</subject><subject>Effects</subject><subject>Flowers & plants</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mechanical properties</subject><subject>osteoporosis</subject><subject>ovariectomy</subject><subject>Rodents</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkU9vEzEQxS0EEqHlwDewkEDisO3YXnvXx6qhgaoCidL2gmR5nbHisLtO7U2h3x5HiXpAQpzmML_35s8j5A2DEwbAT9fZ2xMhtHpGZgx0UwEweE5mpccryWr-krzKeQ0AWis1Iz_mIWYXE1oahk2KD5jptEI6xLRZxQGnFBy145IO6FZ2DM72tGAbTFMoaPS0iyPSMNL4YFNAN8UhZFzSZKd8TF5422d8fahH5Obi4_fzT9XV18Xn87OrytVcqarzQlilXNdy5bDpGNNSSd_oVtVLz5Epqb0EkA06x0B01jkl26XgHTrNrDgi7_e-ZbP7LebJlB0c9r0dMW6zEbKpdXnKf8EyGHQLrIBv_wLXcZvGcoThnKumqRUU6MMecinmnNCbTQqDTY-GgdmlYXZpmF0ahX13MLS5_NAnO7qQnwQcWtbKdsed7rlfocfHfxuay-uLs4NztVeEPOHvJ4VNP41qRCPN3ZeFuf4m53e3i7lpxR9ZAajV</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Chen, Jian-Horng</creator><creator>Wu, James Shih-Shyn</creator><creator>Lin, Hsiao-Che</creator><creator>Wu, Shey-Lin</creator><creator>Wang, Wen-Fu</creator><creator>Huang, Shu-Kuei</creator><creator>Ho, Ying-Jui</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>John Wiley and Sons, Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7QP</scope></search><sort><creationdate>200812</creationdate><title>Dioscorea improves the morphometric and mechanical properties of bone in ovariectomised rats</title><author>Chen, Jian-Horng ; Wu, James Shih-Shyn ; Lin, Hsiao-Che ; Wu, Shey-Lin ; Wang, Wen-Fu ; Huang, Shu-Kuei ; Ho, Ying-Jui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4266-bf33a66cb826ce7b119565f79864df2e1659f50057ecc103bacc658d32bec91a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>bone properties</topic><topic>Bones</topic><topic>Dioscorea</topic><topic>Effects</topic><topic>Flowers & plants</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mechanical properties</topic><topic>osteoporosis</topic><topic>ovariectomy</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jian-Horng</creatorcontrib><creatorcontrib>Wu, James Shih-Shyn</creatorcontrib><creatorcontrib>Lin, Hsiao-Che</creatorcontrib><creatorcontrib>Wu, Shey-Lin</creatorcontrib><creatorcontrib>Wang, Wen-Fu</creatorcontrib><creatorcontrib>Huang, Shu-Kuei</creatorcontrib><creatorcontrib>Ho, Ying-Jui</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jian-Horng</au><au>Wu, James Shih-Shyn</au><au>Lin, Hsiao-Che</au><au>Wu, Shey-Lin</au><au>Wang, Wen-Fu</au><au>Huang, Shu-Kuei</au><au>Ho, Ying-Jui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dioscorea improves the morphometric and mechanical properties of bone in ovariectomised rats</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>2008-12</date><risdate>2008</risdate><volume>88</volume><issue>15</issue><spage>2700</spage><epage>2706</epage><pages>2700-2706</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><coden>JSFAAE</coden><abstract>BACKGROUND: The aim of this work was to determine the effects of oral administration of dioscorea on the morphometric and mechanical properties of the femur in ovariectomised (OVX) rats. Female Wistar rats that had undergone surgery for ovariectomy were used as a model of menopause and osteoporosis. Four weeks after surgery the animals were given oral dioscorea (0, 250, 750 or 1500 mg kg−1 day−1) for 27 days, then the porosity, mineral fraction, stiffness and toughness of the femur and the ultimate force needed to break the femur were measured.
RESULTS: Ovariectomy resulted in an increase in the total volume, dry weight and porosity but a decrease in the mineral fraction of femora. Subsequent chronic administration of dioscorea reversed the effect on porosity and increased the ultimate force of the femur in OVX rats but did not affect the bone properties of sham‐operated rats.
CONCLUSION: These results suggest that chronic administration of dioscorea may enhance bone strength and provide insight into the role of dioscorea in bone remodeling and osteoporosis during the menopause. However, the benefit is not clear for the reproductive female. Copyright © 2008 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jsfa.3396</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5142 |
| ispartof | Journal of the science of food and agriculture, 2008-12, Vol.88 (15), p.2700-2706 |
| issn | 0022-5142 1097-0010 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_35749339 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences bone properties Bones Dioscorea Effects Flowers & plants Food industries Fundamental and applied biological sciences. Psychology Mechanical properties osteoporosis ovariectomy Rodents |
| title | Dioscorea improves the morphometric and mechanical properties of bone in ovariectomised rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T22%3A24%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dioscorea%20improves%20the%20morphometric%20and%20mechanical%20properties%20of%20bone%20in%20ovariectomised%20rats&rft.jtitle=Journal%20of%20the%20science%20of%20food%20and%20agriculture&rft.au=Chen,%20Jian-Horng&rft.date=2008-12&rft.volume=88&rft.issue=15&rft.spage=2700&rft.epage=2706&rft.pages=2700-2706&rft.issn=0022-5142&rft.eissn=1097-0010&rft.coden=JSFAAE&rft_id=info:doi/10.1002/jsfa.3396&rft_dat=%3Cproquest_cross%3E19509801%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222677460&rft_id=info:pmid/&rfr_iscdi=true |