Imperfect vaccines and the evolution of pathogen virulence

Vaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations. We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mo...

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Veröffentlicht in:	Nature (London) 2001-12, Vol.414 (6865), p.751-756
Hauptverfasser:	Gandon, Sylvain, Mackinnon, Margaret J, Nee, Sean, Read, Andrew F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Applied microbiology Biological and medical sciences Biological Evolution Disease Disease Susceptibility Epidemiologic Methods Fundamental and applied biological sciences. Psychology Host-Parasite Interactions Humans Immunity Immunization Programs Infection - epidemiology Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - mortality Malaria, Falciparum - parasitology Microbiology Models, Biological Mortality Pathogens Population Dynamics Prevalence Public health Selection, Genetic Vaccines Vaccines - adverse effects Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vector-borne diseases Virulence Viruses
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