Multiple Functions of the IKK-Related Kinase IKKe in Interferon-Mediated Antiviral Immunity

KK{epsilon} is an IKK (inhibitor of nuclear factor {kappa}Bkinase)-related kinase implicated in virus induction of interferon-Beta (IFNBeta). We report that, although mice lacking IKK{epsilon} produce normal amounts of IFNBeta, they are hypersusceptible to viral infection because of a defect in the...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-03, Vol.315 (5816), p.1274-1278
Hauptverfasser:	tenOever, Benjamin R, Sze-Ling, Ng, Chua, Mark A, McWhirter, Sarah M
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetics Immune system Kinases Pharmacology Signal transduction Virology
Online-Zugang:	Volltext
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