Multiple Functions of the IKK-Related Kinase IKKe in Interferon-Mediated Antiviral Immunity
KK{epsilon} is an IKK (inhibitor of nuclear factor {kappa}Bkinase)-related kinase implicated in virus induction of interferon-Beta (IFNBeta). We report that, although mice lacking IKK{epsilon} produce normal amounts of IFNBeta, they are hypersusceptible to viral infection because of a defect in the...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2007-03, Vol.315 (5816), p.1274-1278 |
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| creator | tenOever, Benjamin R Sze-Ling, Ng Chua, Mark A McWhirter, Sarah M |
| description | KK{epsilon} is an IKK (inhibitor of nuclear factor {kappa}Bkinase)-related kinase implicated in virus induction of interferon-Beta (IFNBeta). We report that, although mice lacking IKK{epsilon} produce normal amounts of IFNBeta, they are hypersusceptible to viral infection because of a defect in the IFN signaling pathway. Specifically, a subset of type I IFN-stimulated genes are not activated in the absence of IKK{epsilon} because the interferon-stimulated gene factor 3 complex (ISGF3) does not bind to promoter elements of the affected genes. We demonstrate that IKK{epsilon} is activated by IFNBeta and that IKK{epsilon} directly phosphorylates signal transducer and activator of transcription 1 (STAT1), a component of ISGF3. We conclude that IKK{epsilon} plays a critical role in the IFN-inducible antiviral transcriptional response. [PUBLICATION ABSTRACT] |
| format | Article |
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We report that, although mice lacking IKK{epsilon} produce normal amounts of IFNBeta, they are hypersusceptible to viral infection because of a defect in the IFN signaling pathway. Specifically, a subset of type I IFN-stimulated genes are not activated in the absence of IKK{epsilon} because the interferon-stimulated gene factor 3 complex (ISGF3) does not bind to promoter elements of the affected genes. We demonstrate that IKK{epsilon} is activated by IFNBeta and that IKK{epsilon} directly phosphorylates signal transducer and activator of transcription 1 (STAT1), a component of ISGF3. We conclude that IKK{epsilon} plays a critical role in the IFN-inducible antiviral transcriptional response. 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| ispartof | Science (American Association for the Advancement of Science), 2007-03, Vol.315 (5816), p.1274-1278 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Genetics Immune system Kinases Pharmacology Signal transduction Virology |
| title | Multiple Functions of the IKK-Related Kinase IKKe in Interferon-Mediated Antiviral Immunity |
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