Human IL-3 and GM-CSF Act Synergistically in Stimulating Hematopoiesis in Primates
Interleukin-3 (IL-3) is a member of a family of growth factors, each of which supports the proliferation and development of hematopoietic precursors in culture. Although the biologic effects of the different hematopoietic growth factors have been well documented in different culture systems, it has...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1988-09, Vol.241 (4874), p.1820-1823 |
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| creator | Donahue, Robert E. Seehra, Jasbir Metzger, Mark Lefebvre, Denise Rock, Brian Carbone, Suzanne Nathan, David G. Garnick, Marc Sehgal, Prabhat K. Laston, David LaVallie, Edward McCoy, John Schendel, Paul F. Norton, Christine Turner, Katherine Yang, Yu-Chang Clark, Steven C. |
| description | Interleukin-3 (IL-3) is a member of a family of growth factors, each of which supports the proliferation and development of hematopoietic precursors in culture. Although the biologic effects of the different hematopoietic growth factors have been well documented in different culture systems, it has only recently become possible to study the activities of these molecules in vivo. In comparison with the later acting hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor, IL-3 elicited a delayed and relatively modest leukocytosis when continuously infused intravenously in primates. The IL-3 infusion, however, greatly potentiated the responsiveness of the animal to subsequent administration of a low dose of GM-CSF. These results suggest that IL-3 expands an early cell population in vivo that subsequently requires the action of a later acting factor such as GM-CSF to complete its development. Optimal stimulation of hematopoiesis may be achieved with combinations of hematopoietic growth factors. |
| doi_str_mv | 10.1126/science.3051378 |
| format | Article |
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Although the biologic effects of the different hematopoietic growth factors have been well documented in different culture systems, it has only recently become possible to study the activities of these molecules in vivo. In comparison with the later acting hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor, IL-3 elicited a delayed and relatively modest leukocytosis when continuously infused intravenously in primates. The IL-3 infusion, however, greatly potentiated the responsiveness of the animal to subsequent administration of a low dose of GM-CSF. These results suggest that IL-3 expands an early cell population in vivo that subsequently requires the action of a later acting factor such as GM-CSF to complete its development. Optimal stimulation of hematopoiesis may be achieved with combinations of hematopoietic growth factors.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3051378</identifier><identifier>PMID: 3051378</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Analysis ; Animals ; Biochemistry ; Biological and medical sciences ; Blood ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Cell proliferation ; Colony-Stimulating Factors - pharmacology ; Drug Synergism ; Eosinophils ; Fundamental and applied biological sciences. Psychology ; Granulocyte-Macrophage Colony-Stimulating Factor ; Growth factors ; Growth Substances - pharmacology ; Hematopoiesis ; Hematopoiesis - drug effects ; Interleukin-3 - pharmacology ; Interleukins ; Laboratory primates ; Leukocyte Count ; Leukocytes ; Leukocytosis ; Macaca fascicularis ; Molecular and cellular biology ; Myeloid cells ; Neutrophils ; Physical growth ; Primates ; Primates as laboratory animals ; Progenitor cells ; Time Factors</subject><ispartof>Science (American Association for the Advancement of Science), 1988-09, Vol.241 (4874), p.1820-1823</ispartof><rights>Copyright 1988 The American Association for the Advancement of Science</rights><rights>1989 INIST-CNRS</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 30, 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c765t-53eb92a229b60d2ab12309bb4a08b88f53ce0f036b2161335b2cefa852c9571e3</citedby><cites>FETCH-LOGICAL-c765t-53eb92a229b60d2ab12309bb4a08b88f53ce0f036b2161335b2cefa852c9571e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1702285$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1702285$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7041351$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3051378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donahue, Robert E.</creatorcontrib><creatorcontrib>Seehra, Jasbir</creatorcontrib><creatorcontrib>Metzger, Mark</creatorcontrib><creatorcontrib>Lefebvre, Denise</creatorcontrib><creatorcontrib>Rock, Brian</creatorcontrib><creatorcontrib>Carbone, Suzanne</creatorcontrib><creatorcontrib>Nathan, David G.</creatorcontrib><creatorcontrib>Garnick, Marc</creatorcontrib><creatorcontrib>Sehgal, Prabhat K.</creatorcontrib><creatorcontrib>Laston, David</creatorcontrib><creatorcontrib>LaVallie, Edward</creatorcontrib><creatorcontrib>McCoy, John</creatorcontrib><creatorcontrib>Schendel, Paul F.</creatorcontrib><creatorcontrib>Norton, Christine</creatorcontrib><creatorcontrib>Turner, Katherine</creatorcontrib><creatorcontrib>Yang, Yu-Chang</creatorcontrib><creatorcontrib>Clark, Steven C.</creatorcontrib><title>Human IL-3 and GM-CSF Act Synergistically in Stimulating Hematopoiesis in Primates</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Interleukin-3 (IL-3) is a member of a family of growth factors, each of which supports the proliferation and development of hematopoietic precursors in culture. Although the biologic effects of the different hematopoietic growth factors have been well documented in different culture systems, it has only recently become possible to study the activities of these molecules in vivo. In comparison with the later acting hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor, IL-3 elicited a delayed and relatively modest leukocytosis when continuously infused intravenously in primates. The IL-3 infusion, however, greatly potentiated the responsiveness of the animal to subsequent administration of a low dose of GM-CSF. These results suggest that IL-3 expands an early cell population in vivo that subsequently requires the action of a later acting factor such as GM-CSF to complete its development. 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Seehra, Jasbir ; Metzger, Mark ; Lefebvre, Denise ; Rock, Brian ; Carbone, Suzanne ; Nathan, David G. ; Garnick, Marc ; Sehgal, Prabhat K. ; Laston, David ; LaVallie, Edward ; McCoy, John ; Schendel, Paul F. ; Norton, Christine ; Turner, Katherine ; Yang, Yu-Chang ; Clark, Steven C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c765t-53eb92a229b60d2ab12309bb4a08b88f53ce0f036b2161335b2cefa852c9571e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Cell proliferation</topic><topic>Colony-Stimulating Factors - pharmacology</topic><topic>Drug Synergism</topic><topic>Eosinophils</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor</topic><topic>Growth factors</topic><topic>Growth Substances - pharmacology</topic><topic>Hematopoiesis</topic><topic>Hematopoiesis - drug effects</topic><topic>Interleukin-3 - pharmacology</topic><topic>Interleukins</topic><topic>Laboratory primates</topic><topic>Leukocyte Count</topic><topic>Leukocytes</topic><topic>Leukocytosis</topic><topic>Macaca fascicularis</topic><topic>Molecular and cellular biology</topic><topic>Myeloid cells</topic><topic>Neutrophils</topic><topic>Physical growth</topic><topic>Primates</topic><topic>Primates as laboratory animals</topic><topic>Progenitor cells</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donahue, Robert E.</creatorcontrib><creatorcontrib>Seehra, Jasbir</creatorcontrib><creatorcontrib>Metzger, Mark</creatorcontrib><creatorcontrib>Lefebvre, Denise</creatorcontrib><creatorcontrib>Rock, 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(American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1988-09-30</date><risdate>1988</risdate><volume>241</volume><issue>4874</issue><spage>1820</spage><epage>1823</epage><pages>1820-1823</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Interleukin-3 (IL-3) is a member of a family of growth factors, each of which supports the proliferation and development of hematopoietic precursors in culture. Although the biologic effects of the different hematopoietic growth factors have been well documented in different culture systems, it has only recently become possible to study the activities of these molecules in vivo. In comparison with the later acting hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor, IL-3 elicited a delayed and relatively modest leukocytosis when continuously infused intravenously in primates. The IL-3 infusion, however, greatly potentiated the responsiveness of the animal to subsequent administration of a low dose of GM-CSF. These results suggest that IL-3 expands an early cell population in vivo that subsequently requires the action of a later acting factor such as GM-CSF to complete its development. Optimal stimulation of hematopoiesis may be achieved with combinations of hematopoietic growth factors.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3051378</pmid><doi>10.1126/science.3051378</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1988-09, Vol.241 (4874), p.1820-1823 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_35215853 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Analysis Animals Biochemistry Biological and medical sciences Blood Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell proliferation Colony-Stimulating Factors - pharmacology Drug Synergism Eosinophils Fundamental and applied biological sciences. Psychology Granulocyte-Macrophage Colony-Stimulating Factor Growth factors Growth Substances - pharmacology Hematopoiesis Hematopoiesis - drug effects Interleukin-3 - pharmacology Interleukins Laboratory primates Leukocyte Count Leukocytes Leukocytosis Macaca fascicularis Molecular and cellular biology Myeloid cells Neutrophils Physical growth Primates Primates as laboratory animals Progenitor cells Time Factors |
| title | Human IL-3 and GM-CSF Act Synergistically in Stimulating Hematopoiesis in Primates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T11%3A18%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20IL-3%20and%20GM-CSF%20Act%20Synergistically%20in%20Stimulating%20Hematopoiesis%20in%20Primates&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Donahue,%20Robert%20E.&rft.date=1988-09-30&rft.volume=241&rft.issue=4874&rft.spage=1820&rft.epage=1823&rft.pages=1820-1823&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.3051378&rft_dat=%3Cgale_proqu%3EA6715440%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213538851&rft_id=info:pmid/3051378&rft_galeid=A6715440&rft_jstor_id=1702285&rfr_iscdi=true |