Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

Many important antibiotics such as tetracyclines, erythromycin, adriamycin, monensin, rifamycin and avermectins are polyketides. In their biosynthesis, multifunctional synthases catalyse iterated condensation of thio-esters derived from acetate, propionate or butyrate to yield aliphatic chains of va...

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Veröffentlicht in:	Nature (London) 1987-02, Vol.325 (6107), p.818-818
Hauptverfasser:	Malpartida, F, Hallam, S E, Kieser, H M, Motamedi, H, Hutchinson, C R, Butler, M J, Sugden, D A, Warren, M, McKillop, C, Bailey, C R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - biosynthesis Anti-Bacterial Agents - biosynthesis Antibiotics Biochemistry Biosynthesis Cloning Cloning, Molecular Deoxyribonucleic acid DNA DNA Restriction Enzymes DNA, Bacterial - genetics DNA, Recombinant Esters Genes, Bacterial Ligases - genetics Medical research Mutation Naphthacenes - biosynthesis Naphthoquinones - biosynthesis Nucleic Acid Hybridization Oxytetracycline - biosynthesis Sequence Homology, Nucleic Acid Streptomyces - genetics Streptomyces - metabolism Synthetic products
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