Stability and compatibility study on enalapril maleate using thermoanalytical techniques
This paper demonstrates the application of thermal analysis in compatibility and stability studies between an ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed during the storage of enalapril maleate tablets. Incompatibi...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2008-09, Vol.93 (3), p.881-886 |
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| container_end_page | 886 |
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| container_title | Journal of thermal analysis and calorimetry |
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| creator | Rezende, R. L. O. Santoro, M. I. R. M. Matos, J. R. |
| description | This paper demonstrates the application of thermal analysis in compatibility and stability studies between an ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed during the storage of enalapril maleate tablets. Incompatibility between enalapril maleate and colloidal silicon dioxide was detected. Besides, it was confirmed that the reaction between enalapril maleate and NaHCO
3
increases the thermal stability of the drug. This study supports the importance of using thermoanalytical methods in the development of pharmaceuticals. |
| doi_str_mv | 10.1007/s10973-007-8187-4 |
| format | Article |
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3
increases the thermal stability of the drug. This study supports the importance of using thermoanalytical methods in the development of pharmaceuticals.</description><identifier>ISSN: 1388-6150</identifier><identifier>EISSN: 1588-2926</identifier><identifier>EISSN: 1572-8943</identifier><identifier>DOI: 10.1007/s10973-007-8187-4</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Analytical Chemistry ; Biological and medical sciences ; Chemistry ; Chemistry and Materials Science ; General pharmacology ; Inorganic Chemistry ; Measurement Science and Instrumentation ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physical Chemistry ; Polymer Sciences</subject><ispartof>Journal of thermal analysis and calorimetry, 2008-09, Vol.93 (3), p.881-886</ispartof><rights>Springer Science+Business Media, LLC. 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-dca2f52edd579f73bfb4919ca864060bf42c74a9b04968bd5e4bb70f9661eee83</citedby><cites>FETCH-LOGICAL-c349t-dca2f52edd579f73bfb4919ca864060bf42c74a9b04968bd5e4bb70f9661eee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10973-007-8187-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10973-007-8187-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20623556$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezende, R. L. O.</creatorcontrib><creatorcontrib>Santoro, M. I. R. M.</creatorcontrib><creatorcontrib>Matos, J. R.</creatorcontrib><title>Stability and compatibility study on enalapril maleate using thermoanalytical techniques</title><title>Journal of thermal analysis and calorimetry</title><addtitle>J Therm Anal Calorim</addtitle><description>This paper demonstrates the application of thermal analysis in compatibility and stability studies between an ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed during the storage of enalapril maleate tablets. Incompatibility between enalapril maleate and colloidal silicon dioxide was detected. Besides, it was confirmed that the reaction between enalapril maleate and NaHCO
3
increases the thermal stability of the drug. This study supports the importance of using thermoanalytical methods in the development of pharmaceuticals.</description><subject>Analytical Chemistry</subject><subject>Biological and medical sciences</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>General pharmacology</subject><subject>Inorganic Chemistry</subject><subject>Measurement Science and Instrumentation</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><issn>1388-6150</issn><issn>1588-2926</issn><issn>1572-8943</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9ULtOxDAQjBBInI77ALo00AVsx4-4RCde0kkUgERnrR3nziiPw3aK_D2OcqKk2tHO7KxmsuwaozuMkLgPGElRFgkWFa5EQc-yFWZVVRBJ-HnCZcIcM3SZbUJwGhGMuGSVXGVf7xG0a12ccujr3AzdEaI7bUIc6ykf-tz20MLRuzbvoLUQbT4G1-_zeLC-GyCxU3QG2jxac-jdz2jDVXbRQBvs5jTX2efT48f2pdi9Pb9uH3aFKamMRW2ANIzYumZCNqLUjaYSSwMVp4gj3VBiBAWpEZW80jWzVGuBGsk5ttZW5Tq7XXyPfpj_RtW5YGzbQm-HMaiSYSEQxkmIF6HxQwjeNioF6sBPCiM116iWGtUM5xoVTTc3J3MIKV7joTcu_B0SxEnJGE86suhCovq99ep7GH2qJfxj_gsWuoSS</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Rezende, R. L. O.</creator><creator>Santoro, M. I. R. M.</creator><creator>Matos, J. R.</creator><general>Springer Netherlands</general><general>Springer</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20080901</creationdate><title>Stability and compatibility study on enalapril maleate using thermoanalytical techniques</title><author>Rezende, R. L. O. ; Santoro, M. I. R. M. ; Matos, J. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-dca2f52edd579f73bfb4919ca864060bf42c74a9b04968bd5e4bb70f9661eee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analytical Chemistry</topic><topic>Biological and medical sciences</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>General pharmacology</topic><topic>Inorganic Chemistry</topic><topic>Measurement Science and Instrumentation</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezende, R. L. O.</creatorcontrib><creatorcontrib>Santoro, M. I. R. M.</creatorcontrib><creatorcontrib>Matos, J. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of thermal analysis and calorimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezende, R. L. O.</au><au>Santoro, M. I. R. M.</au><au>Matos, J. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability and compatibility study on enalapril maleate using thermoanalytical techniques</atitle><jtitle>Journal of thermal analysis and calorimetry</jtitle><stitle>J Therm Anal Calorim</stitle><date>2008-09-01</date><risdate>2008</risdate><volume>93</volume><issue>3</issue><spage>881</spage><epage>886</epage><pages>881-886</pages><issn>1388-6150</issn><eissn>1588-2926</eissn><eissn>1572-8943</eissn><abstract>This paper demonstrates the application of thermal analysis in compatibility and stability studies between an ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed during the storage of enalapril maleate tablets. Incompatibility between enalapril maleate and colloidal silicon dioxide was detected. Besides, it was confirmed that the reaction between enalapril maleate and NaHCO
3
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| subjects | Analytical Chemistry Biological and medical sciences Chemistry Chemistry and Materials Science General pharmacology Inorganic Chemistry Measurement Science and Instrumentation Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Polymer Sciences |
| title | Stability and compatibility study on enalapril maleate using thermoanalytical techniques |
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