DNA Damage and Oxygen Radical Toxicity
A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA damage mediated by a Fenton reaction that generates active forms of hydroxyl radicals from hydrogen peroxide, DNA-bound iron, and a constant source of reducing equivalents. Kinetic peculiarities of DNA dama...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1988-06, Vol.240 (4857), p.1302-1309 |
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| creator | Imlay, James A. Linn, Stuart |
| description | A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA damage mediated by a Fenton reaction that generates active forms of hydroxyl radicals from hydrogen peroxide, DNA-bound iron, and a constant source of reducing equivalents. Kinetic peculiarities of DNA damage production by hydrogen peroxide in vivo can be reproduced by including DNA in an in vitro Fenton reaction system in which iron catalyzes the univalent reduction of hydrogen peroxide by the reduced form of nicotinamide adenine dinucleotide (NADH). To minimize the toxicity of oxygen radicals, the cell utilizes scavengers of these radicals and DNA repair enzymes. On the basis of observations with the model system, it is proposed that the cell may also decrease such toxicity by diminishing available NAD(P)H and by utilizing oxygen itself to scavenge active free radicals into superoxide, which is then destroyed by superoxide dismutase. |
| doi_str_mv | 10.1126/science.3287616 |
| format | Article |
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Kinetic peculiarities of DNA damage production by hydrogen peroxide in vivo can be reproduced by including DNA in an in vitro Fenton reaction system in which iron catalyzes the univalent reduction of hydrogen peroxide by the reduced form of nicotinamide adenine dinucleotide (NADH). To minimize the toxicity of oxygen radicals, the cell utilizes scavengers of these radicals and DNA repair enzymes. On the basis of observations with the model system, it is proposed that the cell may also decrease such toxicity by diminishing available NAD(P)H and by utilizing oxygen itself to scavenge active free radicals into superoxide, which is then destroyed by superoxide dismutase.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3287616</identifier><identifier>PMID: 3287616</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Active oxygen ; Atmosphere ; Biological and medical sciences ; Chemical Phenomena ; Chemistry ; DNA ; DNA Damage ; DNA, Bacterial - drug effects ; Electrons ; Enzymes ; Escherichia coli ; Escherichia coli - drug effects ; Escherichia coli - genetics ; Free radical reactions ; Free Radicals ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Genetics ; Hydrogen peroxide ; Hydrogen Peroxide - pharmacology ; Iron ; Medical research ; Molecular and cellular biology ; Molecular genetics ; Mutagenesis. Repair ; NAD - metabolism ; Oxidation ; Oxidation-Reduction ; Oxygen ; Oxygen - metabolism ; Peroxides ; Physiological aspects ; Radiation damage ; Reactive oxygen species ; Superoxides</subject><ispartof>Science (American Association for the Advancement of Science), 1988-06, Vol.240 (4857), p.1302-1309</ispartof><rights>Copyright 1988 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jun 3, 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c819t-62dc3a7473fc9d931079f794e90d9c843d1e0fb1211ff26d81216ae7cd058fb93</citedby><cites>FETCH-LOGICAL-c819t-62dc3a7473fc9d931079f794e90d9c843d1e0fb1211ff26d81216ae7cd058fb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1701054$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1701054$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7693664$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3287616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imlay, James A.</creatorcontrib><creatorcontrib>Linn, Stuart</creatorcontrib><title>DNA Damage and Oxygen Radical Toxicity</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA damage mediated by a Fenton reaction that generates active forms of hydroxyl radicals from hydrogen peroxide, DNA-bound iron, and a constant source of reducing equivalents. Kinetic peculiarities of DNA damage production by hydrogen peroxide in vivo can be reproduced by including DNA in an in vitro Fenton reaction system in which iron catalyzes the univalent reduction of hydrogen peroxide by the reduced form of nicotinamide adenine dinucleotide (NADH). To minimize the toxicity of oxygen radicals, the cell utilizes scavengers of these radicals and DNA repair enzymes. On the basis of observations with the model system, it is proposed that the cell may also decrease such toxicity by diminishing available NAD(P)H and by utilizing oxygen itself to scavenge active free radicals into superoxide, which is then destroyed by superoxide dismutase.</description><subject>Active oxygen</subject><subject>Atmosphere</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>DNA, Bacterial - drug effects</subject><subject>Electrons</subject><subject>Enzymes</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - genetics</subject><subject>Free radical reactions</subject><subject>Free Radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Iron</subject><subject>Medical research</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Mutagenesis. Repair</subject><subject>NAD - metabolism</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Oxygen</subject><subject>Oxygen - metabolism</subject><subject>Peroxides</subject><subject>Physiological aspects</subject><subject>Radiation damage</subject><subject>Reactive oxygen species</subject><subject>Superoxides</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0s9v0zAUB3ALgUYZnLmAFCE0DiObfyR2fCwdlEnVKsHgarn2c5QqP4adSO1_j6tG20CVVvkQy--T9-Tki9Bbgi8IofwymApaAxeMFoIT_gxNCJZ5Kilmz9EEY8bTAov8JXoVwhrjWJPsBJ2MfILOrm6myZVudAmJbm2y3GxLaJMf2lZG18ltt6lM1W9foxdO1wHejM9T9Ovb19vZ93SxnF_PpovUFET2KafWMC0ywZyRVjKChXRCZiCxlabImCWA3YpQQpyj3BZxxzUIY3FeuJVkp-hs3_fOd38GCL1qqmCgrnUL3RAUywmLbcSTME7IaY75k5DkhDJR7EZ_-A-uu8G38baxGcsZpoJFdL5Hpa5BVa3req9N_GLgdd214Kp4POVCYCp3-vMBHZeFpjIH-Kd_eBQ9bPpSDyGo6583x8rl72Pll_mRspgvHsvzQ9J0dQ0lqBiI2fKxvtxr47sQPDh156tG-60iWO0yrMYMqzGU8Y33458YVg3Ye_9Q_zjWdYghdV63pgr3THDJOM8ie7dn69B3_mGqwATnGfsLE-X76A</recordid><startdate>19880603</startdate><enddate>19880603</enddate><creator>Imlay, James A.</creator><creator>Linn, Stuart</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope></search><sort><creationdate>19880603</creationdate><title>DNA Damage and Oxygen Radical Toxicity</title><author>Imlay, James A. ; Linn, Stuart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c819t-62dc3a7473fc9d931079f794e90d9c843d1e0fb1211ff26d81216ae7cd058fb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Active oxygen</topic><topic>Atmosphere</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>DNA, Bacterial - drug effects</topic><topic>Electrons</topic><topic>Enzymes</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - genetics</topic><topic>Free radical reactions</topic><topic>Free Radicals</topic><topic>Fundamental and applied biological sciences. 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Kinetic peculiarities of DNA damage production by hydrogen peroxide in vivo can be reproduced by including DNA in an in vitro Fenton reaction system in which iron catalyzes the univalent reduction of hydrogen peroxide by the reduced form of nicotinamide adenine dinucleotide (NADH). To minimize the toxicity of oxygen radicals, the cell utilizes scavengers of these radicals and DNA repair enzymes. On the basis of observations with the model system, it is proposed that the cell may also decrease such toxicity by diminishing available NAD(P)H and by utilizing oxygen itself to scavenge active free radicals into superoxide, which is then destroyed by superoxide dismutase.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3287616</pmid><doi>10.1126/science.3287616</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1988-06, Vol.240 (4857), p.1302-1309 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Active oxygen Atmosphere Biological and medical sciences Chemical Phenomena Chemistry DNA DNA Damage DNA, Bacterial - drug effects Electrons Enzymes Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Free radical reactions Free Radicals Fundamental and applied biological sciences. Psychology Genetic aspects Genetics Hydrogen peroxide Hydrogen Peroxide - pharmacology Iron Medical research Molecular and cellular biology Molecular genetics Mutagenesis. Repair NAD - metabolism Oxidation Oxidation-Reduction Oxygen Oxygen - metabolism Peroxides Physiological aspects Radiation damage Reactive oxygen species Superoxides |
| title | DNA Damage and Oxygen Radical Toxicity |
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