Characterization of ribosomal frameshifting in HIV-1 gag-pol expression

Based on precedents from other retroviruses, the precursor of the human immunodeficiency virus (HIV-1) reverse transcriptase is predicted to be a polyprotein with a relative molecular mass (Mr) of 160,000 (160K) encoded by both the viral pol gene and the upstream gag gene. These two genes lie in dif...

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Veröffentlicht in:	Nature (London) 1988-01, Vol.331 (6153), p.280-283
Hauptverfasser:	Jacks, Tyler, Power, Michael D, Masiarz, Frank R, Luciw, Paul A, Barr, Philip J, Varmus, Harold E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Amino Acid Sequence Base Sequence Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Products, gag Genetics HIV - genetics Human immunodeficiency virus 1 Medical research Microbiology Molecular Sequence Data Nucleic Acid Conformation Protein Biosynthesis Retroviridae Proteins - biosynthesis Retroviridae Proteins - genetics Retrovirus Ribosomes - physiology RNA-Directed DNA Polymerase - biosynthesis RNA-Directed DNA Polymerase - genetics Sarcoma Viral Fusion Proteins - biosynthesis Viral Fusion Proteins - genetics Virology Viruses
Online-Zugang:	Volltext
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