The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

Abstract Blocking the binding of TNF-α to TNF receptor subtype-1 (TNFR1) is an important strategy for the treatment of rheumatoid arthritis (RA). We recently succeeded in developing a TNFR1-selective antagonistic TNF mutant, R1antTNF. Here, we report the anti-inflammatory effects of R1antTNF in a mu...

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Veröffentlicht in:	Biomaterials 2009-12, Vol.30 (34), p.6638-6647
Hauptverfasser:	Shibata, Hiroko, Yoshioka, Yasuo, Abe, Yasuhiro, Ohkawa, Akiko, Nomura, Tetsuya, Minowa, Kyoko, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Cell Proliferation Collagen - toxicity Cytokine receptors Cytokines Dentistry Female Mice Mice, Inbred Strains Mutation Osteoclasts - cytology Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors Rheumatoid arthritis Surface Plasmon Resonance Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - therapeutic use
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