Quantitative determination of the biological activity of botulinum toxin type A by measuring the compound muscle action potential (CMAP) in rats

Quantitative determination of the biological activity of botulinum toxin type A usually depends on the LD 50 method after intraperitoneal injection into mice. This method requires a large number of mice to determine the toxic activity at a high level of precision and 3–4 days to obtain the results....

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