Determination of pharmaceuticals classified as emerging pollutants using capillary electrophoresis with capacitively coupled contactless conductivity detection
A study on the simultaneous separation of 13 pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection was presented. The parameters of the background electrolyte, such as pH, organic additives as well as types and concentrations of cyclodextri...
Gespeichert in:
| Veröffentlicht in: | Electrophoresis 2008-08, Vol.29 (17), p.3701-3709 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3709 |
|---|---|
| container_issue | 17 |
| container_start_page | 3701 |
| container_title | Electrophoresis |
| container_volume | 29 |
| creator | Quek, Ngee Mien Law, Wai Siang Lau, Hiu Fung Zhao, Jian Hong Hauser, Peter C. Li, Sam Fong Yau |
| description | A study on the simultaneous separation of 13 pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection was presented. The parameters of the background electrolyte, such as pH, organic additives as well as types and concentrations of cyclodextrins (CD) were studied. The optimal separation conditions were achieved with a background electrolyte consisting of 9 mM Tris/5 mM lactic acid at pH 8.0, containing 5% n‐propanol, 0.025% γ‐CD, 0.075% hydroxyl‐β‐CD and 0.15% dimethyl‐β‐CD. Limits of detections ranged from 61 to 1676 μg/L (S/N=3) and the relative standard deviations for migration time and peak area were below 2 and 6%, respectively. This demonstrated the potential of the capillary electrophoresis‐capacitively coupled contactless conductivity detection method for biomedical and environmental analysis, as shown in the determination of pharmaceuticals identified as emerging pollutants in water samples. |
| doi_str_mv | 10.1002/elps.200800153 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_34765151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>34765151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4523-faadec4b353f06538073b33341709e18fe206cfcd6aa50a37049ff501520ecec3</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS0EokNhyxJ5xS7DdRwnmSWU0lYKPxIg2Fke57pjcOLUdmjnaXhVHM2osGNly_7O0bn3EPKcwZoBlK_QTXFdArQATPAHZMVEWRZl3fKHZAWs4QW0XJyQJzH-AIBqU1WPyQlrW-CsFSvy-y0mDIMdVbJ-pN7QaafCoDTOyWrlItVOxWiNxZ6qSHHAcG3Hazp55-akxhTpHJcHrSbrnAp7ig51Cn7a-YDRRnpr0275Vtom-wvdnmo_Ty4baj8mpZPDGJd7P-sM2LSnfU6ll0RPySOTU-Cz43lKvr47_3J2WXQfL67OXneFrkTJC6NUj7racsEN1IK30PAt57xiDWyQtQZLqLXRfa2UAMWbvAljRN5ZCahR81Py8uA7BX8zY0xysFFjHmhEP0fJq6YWTLAMrg-gDj7GgEZOwQ55bMlALpXIpRJ5X0kWvDg6z9sB-7_4sYMMbA7ArXW4_4-dPO8-ff7XvDhobUx4d69V4aesG94I-e3DhXxTXvKu-87ke_4HjdCt1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>34765151</pqid></control><display><type>article</type><title>Determination of pharmaceuticals classified as emerging pollutants using capillary electrophoresis with capacitively coupled contactless conductivity detection</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Quek, Ngee Mien ; Law, Wai Siang ; Lau, Hiu Fung ; Zhao, Jian Hong ; Hauser, Peter C. ; Li, Sam Fong Yau</creator><creatorcontrib>Quek, Ngee Mien ; Law, Wai Siang ; Lau, Hiu Fung ; Zhao, Jian Hong ; Hauser, Peter C. ; Li, Sam Fong Yau</creatorcontrib><description>A study on the simultaneous separation of 13 pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection was presented. The parameters of the background electrolyte, such as pH, organic additives as well as types and concentrations of cyclodextrins (CD) were studied. The optimal separation conditions were achieved with a background electrolyte consisting of 9 mM Tris/5 mM lactic acid at pH 8.0, containing 5% n‐propanol, 0.025% γ‐CD, 0.075% hydroxyl‐β‐CD and 0.15% dimethyl‐β‐CD. Limits of detections ranged from 61 to 1676 μg/L (S/N=3) and the relative standard deviations for migration time and peak area were below 2 and 6%, respectively. This demonstrated the potential of the capillary electrophoresis‐capacitively coupled contactless conductivity detection method for biomedical and environmental analysis, as shown in the determination of pharmaceuticals identified as emerging pollutants in water samples.</description><identifier>ISSN: 0173-0835</identifier><identifier>EISSN: 1522-2683</identifier><identifier>DOI: 10.1002/elps.200800153</identifier><identifier>PMID: 18803185</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Capacitively coupled contactless conductivity detection ; Conventional capillary electrophoresis ; Cyclodextrins - chemistry ; Electrophoresis, Capillary - methods ; Emerging pollutants ; Hydrogen-Ion Concentration ; Pharmaceutical Preparations - analysis ; Pharmaceuticals ; Sensitivity and Specificity ; Solvents ; Water Pollutants, Chemical - analysis</subject><ispartof>Electrophoresis, 2008-08, Vol.29 (17), p.3701-3709</ispartof><rights>Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4523-faadec4b353f06538073b33341709e18fe206cfcd6aa50a37049ff501520ecec3</citedby><cites>FETCH-LOGICAL-c4523-faadec4b353f06538073b33341709e18fe206cfcd6aa50a37049ff501520ecec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Felps.200800153$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Felps.200800153$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18803185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quek, Ngee Mien</creatorcontrib><creatorcontrib>Law, Wai Siang</creatorcontrib><creatorcontrib>Lau, Hiu Fung</creatorcontrib><creatorcontrib>Zhao, Jian Hong</creatorcontrib><creatorcontrib>Hauser, Peter C.</creatorcontrib><creatorcontrib>Li, Sam Fong Yau</creatorcontrib><title>Determination of pharmaceuticals classified as emerging pollutants using capillary electrophoresis with capacitively coupled contactless conductivity detection</title><title>Electrophoresis</title><addtitle>ELECTROPHORESIS</addtitle><description>A study on the simultaneous separation of 13 pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection was presented. The parameters of the background electrolyte, such as pH, organic additives as well as types and concentrations of cyclodextrins (CD) were studied. The optimal separation conditions were achieved with a background electrolyte consisting of 9 mM Tris/5 mM lactic acid at pH 8.0, containing 5% n‐propanol, 0.025% γ‐CD, 0.075% hydroxyl‐β‐CD and 0.15% dimethyl‐β‐CD. Limits of detections ranged from 61 to 1676 μg/L (S/N=3) and the relative standard deviations for migration time and peak area were below 2 and 6%, respectively. This demonstrated the potential of the capillary electrophoresis‐capacitively coupled contactless conductivity detection method for biomedical and environmental analysis, as shown in the determination of pharmaceuticals identified as emerging pollutants in water samples.</description><subject>Capacitively coupled contactless conductivity detection</subject><subject>Conventional capillary electrophoresis</subject><subject>Cyclodextrins - chemistry</subject><subject>Electrophoresis, Capillary - methods</subject><subject>Emerging pollutants</subject><subject>Hydrogen-Ion Concentration</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceuticals</subject><subject>Sensitivity and Specificity</subject><subject>Solvents</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>0173-0835</issn><issn>1522-2683</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokNhyxJ5xS7DdRwnmSWU0lYKPxIg2Fke57pjcOLUdmjnaXhVHM2osGNly_7O0bn3EPKcwZoBlK_QTXFdArQATPAHZMVEWRZl3fKHZAWs4QW0XJyQJzH-AIBqU1WPyQlrW-CsFSvy-y0mDIMdVbJ-pN7QaafCoDTOyWrlItVOxWiNxZ6qSHHAcG3Hazp55-akxhTpHJcHrSbrnAp7ig51Cn7a-YDRRnpr0275Vtom-wvdnmo_Ty4baj8mpZPDGJd7P-sM2LSnfU6ll0RPySOTU-Cz43lKvr47_3J2WXQfL67OXneFrkTJC6NUj7racsEN1IK30PAt57xiDWyQtQZLqLXRfa2UAMWbvAljRN5ZCahR81Py8uA7BX8zY0xysFFjHmhEP0fJq6YWTLAMrg-gDj7GgEZOwQ55bMlALpXIpRJ5X0kWvDg6z9sB-7_4sYMMbA7ArXW4_4-dPO8-ff7XvDhobUx4d69V4aesG94I-e3DhXxTXvKu-87ke_4HjdCt1g</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Quek, Ngee Mien</creator><creator>Law, Wai Siang</creator><creator>Lau, Hiu Fung</creator><creator>Zhao, Jian Hong</creator><creator>Hauser, Peter C.</creator><creator>Li, Sam Fong Yau</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>200808</creationdate><title>Determination of pharmaceuticals classified as emerging pollutants using capillary electrophoresis with capacitively coupled contactless conductivity detection</title><author>Quek, Ngee Mien ; Law, Wai Siang ; Lau, Hiu Fung ; Zhao, Jian Hong ; Hauser, Peter C. ; Li, Sam Fong Yau</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4523-faadec4b353f06538073b33341709e18fe206cfcd6aa50a37049ff501520ecec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Capacitively coupled contactless conductivity detection</topic><topic>Conventional capillary electrophoresis</topic><topic>Cyclodextrins - chemistry</topic><topic>Electrophoresis, Capillary - methods</topic><topic>Emerging pollutants</topic><topic>Hydrogen-Ion Concentration</topic><topic>Pharmaceutical Preparations - analysis</topic><topic>Pharmaceuticals</topic><topic>Sensitivity and Specificity</topic><topic>Solvents</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quek, Ngee Mien</creatorcontrib><creatorcontrib>Law, Wai Siang</creatorcontrib><creatorcontrib>Lau, Hiu Fung</creatorcontrib><creatorcontrib>Zhao, Jian Hong</creatorcontrib><creatorcontrib>Hauser, Peter C.</creatorcontrib><creatorcontrib>Li, Sam Fong Yau</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Electrophoresis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quek, Ngee Mien</au><au>Law, Wai Siang</au><au>Lau, Hiu Fung</au><au>Zhao, Jian Hong</au><au>Hauser, Peter C.</au><au>Li, Sam Fong Yau</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of pharmaceuticals classified as emerging pollutants using capillary electrophoresis with capacitively coupled contactless conductivity detection</atitle><jtitle>Electrophoresis</jtitle><addtitle>ELECTROPHORESIS</addtitle><date>2008-08</date><risdate>2008</risdate><volume>29</volume><issue>17</issue><spage>3701</spage><epage>3709</epage><pages>3701-3709</pages><issn>0173-0835</issn><eissn>1522-2683</eissn><abstract>A study on the simultaneous separation of 13 pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection was presented. The parameters of the background electrolyte, such as pH, organic additives as well as types and concentrations of cyclodextrins (CD) were studied. The optimal separation conditions were achieved with a background electrolyte consisting of 9 mM Tris/5 mM lactic acid at pH 8.0, containing 5% n‐propanol, 0.025% γ‐CD, 0.075% hydroxyl‐β‐CD and 0.15% dimethyl‐β‐CD. Limits of detections ranged from 61 to 1676 μg/L (S/N=3) and the relative standard deviations for migration time and peak area were below 2 and 6%, respectively. This demonstrated the potential of the capillary electrophoresis‐capacitively coupled contactless conductivity detection method for biomedical and environmental analysis, as shown in the determination of pharmaceuticals identified as emerging pollutants in water samples.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>18803185</pmid><doi>10.1002/elps.200800153</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0173-0835 |
| ispartof | Electrophoresis, 2008-08, Vol.29 (17), p.3701-3709 |
| issn | 0173-0835 1522-2683 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_34765151 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Capacitively coupled contactless conductivity detection Conventional capillary electrophoresis Cyclodextrins - chemistry Electrophoresis, Capillary - methods Emerging pollutants Hydrogen-Ion Concentration Pharmaceutical Preparations - analysis Pharmaceuticals Sensitivity and Specificity Solvents Water Pollutants, Chemical - analysis |
| title | Determination of pharmaceuticals classified as emerging pollutants using capillary electrophoresis with capacitively coupled contactless conductivity detection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T04%3A14%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determination%20of%20pharmaceuticals%20classified%20as%20emerging%20pollutants%20using%20capillary%20electrophoresis%20with%20capacitively%20coupled%20contactless%20conductivity%20detection&rft.jtitle=Electrophoresis&rft.au=Quek,%20Ngee%20Mien&rft.date=2008-08&rft.volume=29&rft.issue=17&rft.spage=3701&rft.epage=3709&rft.pages=3701-3709&rft.issn=0173-0835&rft.eissn=1522-2683&rft_id=info:doi/10.1002/elps.200800153&rft_dat=%3Cproquest_cross%3E34765151%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=34765151&rft_id=info:pmid/18803185&rfr_iscdi=true |