Copper‐Catalyzed N‐Arylation/Hydroamin(d)ation Domino Synthesis of Indoles and its Application to the Preparation of a Chek1/KDR Kinase Inhibitor Pharmacophore
Inexpensive copper catalysts allow for efficient syntheses of N‐aryl‐, N‐acyl‐, or N‐H‐(aza)indoles starting from ortho‐alkynylbromoarenes. The broad scope of this domino N‐arylation/hydroamin(d)ation process is highlighted by the synthesis of highly functionalized indoles, as well as of a Chek1/KDR...
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| Veröffentlicht in: | Advanced synthesis & catalysis 2009-05, Vol.351 (7‐8), p.1064-1072 |
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| container_end_page | 1072 |
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| container_issue | 7‐8 |
| container_start_page | 1064 |
| container_title | Advanced synthesis & catalysis |
| container_volume | 351 |
| creator | Ackermann, Lutz Barfüßer, Sebastian Potukuchi, Harish K. |
| description | Inexpensive copper catalysts allow for efficient syntheses of N‐aryl‐, N‐acyl‐, or N‐H‐(aza)indoles starting from ortho‐alkynylbromoarenes. The broad scope of this domino N‐arylation/hydroamin(d)ation process is highlighted by the synthesis of highly functionalized indoles, as well as of a Chek1/KDR inhibitor pharmacophore. |
| doi_str_mv | 10.1002/adsc.200900004 |
| format | Article |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | amination arylation catalysis copper hydroamination indoles |
| title | Copper‐Catalyzed N‐Arylation/Hydroamin(d)ation Domino Synthesis of Indoles and its Application to the Preparation of a Chek1/KDR Kinase Inhibitor Pharmacophore |
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