Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E

Sexually mature male Wistar rats (weighing 300–320 g and each group 6 animals) were given malathion (27 mg/kg; 1/50 of the LD 50 for an oral dose) and/or vitamin C (200 mg/kg) + vitamin E (200 mg/kg) daily via gavage for 4 weeks. The sperm counts, sperm motility, sperm morphology, FSH, LH, and testo...

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Veröffentlicht in:	Food and chemical toxicology 2009-08, Vol.47 (8), p.1903-1908
Hauptverfasser:	Uzun, Fatma Gokce, Kalender, Suna, Durak, Dilek, Demir, Filiz, Kalender, Yusuf
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antioxidants - pharmacology ascorbic acid Ascorbic Acid - pharmacology Biological and medical sciences edema Epididymis - drug effects Epididymis - pathology Follicle Stimulating Hormone - blood follicle-stimulating hormone Histopathology human health Insecticides - antagonists & inhibitors Insecticides - toxicity interstitial tissues luteinizing hormone Luteinizing Hormone - blood Malathion Malathion - antagonists & inhibitors Malathion - toxicity Male Medical sciences necrosis Organophosphate insecticide Pesticides, fertilizers and other agrochemicals toxicology protective effect Rats seminiferous tubules Sperm Count sperm motility Sperm Motility - drug effects spermatozoa Spermatozoa - drug effects Spermatozoa - ultrastructure synergism testes Testicular Diseases - chemically induced Testicular Diseases - pathology Testicular toxicity Testis - pathology testosterone Testosterone - blood toxicity Toxicology Vitamin C Vitamin E Vitamin E - pharmacology vitamin supplements xenobiotics
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