Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E
Sexually mature male Wistar rats (weighing 300–320 g and each group 6 animals) were given malathion (27 mg/kg; 1/50 of the LD 50 for an oral dose) and/or vitamin C (200 mg/kg) + vitamin E (200 mg/kg) daily via gavage for 4 weeks. The sperm counts, sperm motility, sperm morphology, FSH, LH, and testo...
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| creator | Uzun, Fatma Gokce Kalender, Suna Durak, Dilek Demir, Filiz Kalender, Yusuf |
| description | Sexually mature male Wistar rats (weighing 300–320
g and each group 6 animals) were given malathion (27
mg/kg; 1/50 of the LD
50 for an oral dose) and/or vitamin C (200
mg/kg)
+
vitamin E (200
mg/kg) daily
via gavage for 4
weeks. The sperm counts, sperm motility, sperm morphology, FSH, LH, and testosterone levels, and histopathological changes in the testes of these rats, were investigated at the end of the 4th week. By the end of 4th week, rats given malathion alone, or in combination with vitamins C and E, had significantly lower sperm counts and sperm motility, and significantly higher abnormal sperm numbers, than the untreated control rats. The rats given malathion alone or in combination with vitamins also had significantly lower plasma FSH, LH and testosterone levels than the control rats. Co-treatment of malathion-exposed rats with vitamins E and C had a protective effect on sperm counts, sperm motility and abnormal sperm numbers, but not on plasma FSH, LH and testosterone levels. Light microscopic investigations revealed that 4
weeks of malathion exposure was associated with necrosis and edema in the seminiferous tubules and interstitial tissues. Degenerative changes in the seminiferous tubules were also observed in the rats which received malathion and supplemented with vitamins C and E, but milder histopathological changes were observed in the interstitial tissues. Thus, it appears that vitamins C and E ameliorate malathion testicular toxicity but are not completely protective. |
| doi_str_mv | 10.1016/j.fct.2009.05.001 |
| format | Article |
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g and each group 6 animals) were given malathion (27
mg/kg; 1/50 of the LD
50 for an oral dose) and/or vitamin C (200
mg/kg)
+
vitamin E (200
mg/kg) daily
via gavage for 4
weeks. The sperm counts, sperm motility, sperm morphology, FSH, LH, and testosterone levels, and histopathological changes in the testes of these rats, were investigated at the end of the 4th week. By the end of 4th week, rats given malathion alone, or in combination with vitamins C and E, had significantly lower sperm counts and sperm motility, and significantly higher abnormal sperm numbers, than the untreated control rats. The rats given malathion alone or in combination with vitamins also had significantly lower plasma FSH, LH and testosterone levels than the control rats. Co-treatment of malathion-exposed rats with vitamins E and C had a protective effect on sperm counts, sperm motility and abnormal sperm numbers, but not on plasma FSH, LH and testosterone levels. Light microscopic investigations revealed that 4
weeks of malathion exposure was associated with necrosis and edema in the seminiferous tubules and interstitial tissues. Degenerative changes in the seminiferous tubules were also observed in the rats which received malathion and supplemented with vitamins C and E, but milder histopathological changes were observed in the interstitial tissues. Thus, it appears that vitamins C and E ameliorate malathion testicular toxicity but are not completely protective.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2009.05.001</identifier><identifier>PMID: 19442699</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>animal models ; Animals ; Antioxidants - pharmacology ; ascorbic acid ; Ascorbic Acid - pharmacology ; Biological and medical sciences ; edema ; Epididymis - drug effects ; Epididymis - pathology ; Follicle Stimulating Hormone - blood ; follicle-stimulating hormone ; Histopathology ; human health ; Insecticides - antagonists & inhibitors ; Insecticides - toxicity ; interstitial tissues ; luteinizing hormone ; Luteinizing Hormone - blood ; Malathion ; Malathion - antagonists & inhibitors ; Malathion - toxicity ; Male ; Medical sciences ; necrosis ; Organophosphate insecticide ; Pesticides, fertilizers and other agrochemicals toxicology ; protective effect ; Rats ; seminiferous tubules ; Sperm Count ; sperm motility ; Sperm Motility - drug effects ; spermatozoa ; Spermatozoa - drug effects ; Spermatozoa - ultrastructure ; synergism ; testes ; Testicular Diseases - chemically induced ; Testicular Diseases - pathology ; Testicular toxicity ; Testis - pathology ; testosterone ; Testosterone - blood ; toxicity ; Toxicology ; Vitamin C ; Vitamin E ; Vitamin E - pharmacology ; vitamin supplements ; xenobiotics</subject><ispartof>Food and chemical toxicology, 2009-08, Vol.47 (8), p.1903-1908</ispartof><rights>2009 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-dd4fbdb6dd7a4e4b5f559d3cd7bee1a2a76032bf867e167f41a87ddfe6d8f0423</citedby><cites>FETCH-LOGICAL-c533t-dd4fbdb6dd7a4e4b5f559d3cd7bee1a2a76032bf867e167f41a87ddfe6d8f0423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2009.05.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21798058$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19442699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uzun, Fatma Gokce</creatorcontrib><creatorcontrib>Kalender, Suna</creatorcontrib><creatorcontrib>Durak, Dilek</creatorcontrib><creatorcontrib>Demir, Filiz</creatorcontrib><creatorcontrib>Kalender, Yusuf</creatorcontrib><title>Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Sexually mature male Wistar rats (weighing 300–320
g and each group 6 animals) were given malathion (27
mg/kg; 1/50 of the LD
50 for an oral dose) and/or vitamin C (200
mg/kg)
+
vitamin E (200
mg/kg) daily
via gavage for 4
weeks. The sperm counts, sperm motility, sperm morphology, FSH, LH, and testosterone levels, and histopathological changes in the testes of these rats, were investigated at the end of the 4th week. By the end of 4th week, rats given malathion alone, or in combination with vitamins C and E, had significantly lower sperm counts and sperm motility, and significantly higher abnormal sperm numbers, than the untreated control rats. The rats given malathion alone or in combination with vitamins also had significantly lower plasma FSH, LH and testosterone levels than the control rats. Co-treatment of malathion-exposed rats with vitamins E and C had a protective effect on sperm counts, sperm motility and abnormal sperm numbers, but not on plasma FSH, LH and testosterone levels. Light microscopic investigations revealed that 4
weeks of malathion exposure was associated with necrosis and edema in the seminiferous tubules and interstitial tissues. Degenerative changes in the seminiferous tubules were also observed in the rats which received malathion and supplemented with vitamins C and E, but milder histopathological changes were observed in the interstitial tissues. Thus, it appears that vitamins C and E ameliorate malathion testicular toxicity but are not completely protective.</description><subject>animal models</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>ascorbic acid</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>edema</subject><subject>Epididymis - drug effects</subject><subject>Epididymis - pathology</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>follicle-stimulating hormone</subject><subject>Histopathology</subject><subject>human health</subject><subject>Insecticides - antagonists & inhibitors</subject><subject>Insecticides - toxicity</subject><subject>interstitial tissues</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Malathion</subject><subject>Malathion - antagonists & inhibitors</subject><subject>Malathion - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>necrosis</subject><subject>Organophosphate insecticide</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>protective effect</subject><subject>Rats</subject><subject>seminiferous tubules</subject><subject>Sperm Count</subject><subject>sperm motility</subject><subject>Sperm Motility - drug effects</subject><subject>spermatozoa</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - ultrastructure</subject><subject>synergism</subject><subject>testes</subject><subject>Testicular Diseases - chemically induced</subject><subject>Testicular Diseases - pathology</subject><subject>Testicular toxicity</subject><subject>Testis - pathology</subject><subject>testosterone</subject><subject>Testosterone - blood</subject><subject>toxicity</subject><subject>Toxicology</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamin E - pharmacology</subject><subject>vitamin supplements</subject><subject>xenobiotics</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1vFDEQhi0EIpfAD6ABN9Dt4m_viio6hYAURAGpjdceE5_2I9jeE_n3-LgTdFB5imfG7zyD0AtKWkqoertrgystI6RviWwJoY_QhnaaN4pL-hhtCNNdo3oqz9B5zjtCiKZaPUVntBeCqb7foG-f7GjLXVzmJs5-deBxgVyiW0ebcFl-RhfLA44znuwIONmSsZ0rdAf4Pi0FXIl7wBBCrfAS8D4WO8U54-1v7uoZehLsmOH56b1At--vvm4_NDefrz9uL28aJzkvjfciDH5Q3msrQAwySNl77rweAKhlVivC2RA6pYEqHQS1nfY-gPJdIILxC_TmOLem-rHWFcwUs4NxtDMsazZcKNJRIf4LMkKFYrSvID2CLi05JwjmPsXJpgdDiTn4NztT_ZuDf0Okqf5rz8vT8HWYwP_tOAmvwOsTYLOzY0h2djH_4RjVfUdkV7lXRy7YxdjvqTK3X2o0Xv9VHWeHhd8dCahW9xGSyS7CXC8YU72F8Uv8R9BfmGutAQ</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Uzun, Fatma Gokce</creator><creator>Kalender, Suna</creator><creator>Durak, Dilek</creator><creator>Demir, Filiz</creator><creator>Kalender, Yusuf</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>20090801</creationdate><title>Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E</title><author>Uzun, Fatma Gokce ; Kalender, Suna ; Durak, Dilek ; Demir, Filiz ; Kalender, Yusuf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-dd4fbdb6dd7a4e4b5f559d3cd7bee1a2a76032bf867e167f41a87ddfe6d8f0423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>ascorbic acid</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Biological and medical sciences</topic><topic>edema</topic><topic>Epididymis - drug effects</topic><topic>Epididymis - pathology</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>follicle-stimulating hormone</topic><topic>Histopathology</topic><topic>human health</topic><topic>Insecticides - antagonists & inhibitors</topic><topic>Insecticides - toxicity</topic><topic>interstitial tissues</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Malathion</topic><topic>Malathion - antagonists & inhibitors</topic><topic>Malathion - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>necrosis</topic><topic>Organophosphate insecticide</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>protective effect</topic><topic>Rats</topic><topic>seminiferous tubules</topic><topic>Sperm Count</topic><topic>sperm motility</topic><topic>Sperm Motility - drug effects</topic><topic>spermatozoa</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - ultrastructure</topic><topic>synergism</topic><topic>testes</topic><topic>Testicular Diseases - chemically induced</topic><topic>Testicular Diseases - pathology</topic><topic>Testicular toxicity</topic><topic>Testis - pathology</topic><topic>testosterone</topic><topic>Testosterone - blood</topic><topic>toxicity</topic><topic>Toxicology</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamin E - pharmacology</topic><topic>vitamin supplements</topic><topic>xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uzun, Fatma Gokce</creatorcontrib><creatorcontrib>Kalender, Suna</creatorcontrib><creatorcontrib>Durak, Dilek</creatorcontrib><creatorcontrib>Demir, Filiz</creatorcontrib><creatorcontrib>Kalender, Yusuf</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uzun, Fatma Gokce</au><au>Kalender, Suna</au><au>Durak, Dilek</au><au>Demir, Filiz</au><au>Kalender, Yusuf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>47</volume><issue>8</issue><spage>1903</spage><epage>1908</epage><pages>1903-1908</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Sexually mature male Wistar rats (weighing 300–320
g and each group 6 animals) were given malathion (27
mg/kg; 1/50 of the LD
50 for an oral dose) and/or vitamin C (200
mg/kg)
+
vitamin E (200
mg/kg) daily
via gavage for 4
weeks. The sperm counts, sperm motility, sperm morphology, FSH, LH, and testosterone levels, and histopathological changes in the testes of these rats, were investigated at the end of the 4th week. By the end of 4th week, rats given malathion alone, or in combination with vitamins C and E, had significantly lower sperm counts and sperm motility, and significantly higher abnormal sperm numbers, than the untreated control rats. The rats given malathion alone or in combination with vitamins also had significantly lower plasma FSH, LH and testosterone levels than the control rats. Co-treatment of malathion-exposed rats with vitamins E and C had a protective effect on sperm counts, sperm motility and abnormal sperm numbers, but not on plasma FSH, LH and testosterone levels. Light microscopic investigations revealed that 4
weeks of malathion exposure was associated with necrosis and edema in the seminiferous tubules and interstitial tissues. Degenerative changes in the seminiferous tubules were also observed in the rats which received malathion and supplemented with vitamins C and E, but milder histopathological changes were observed in the interstitial tissues. Thus, it appears that vitamins C and E ameliorate malathion testicular toxicity but are not completely protective.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>19442699</pmid><doi>10.1016/j.fct.2009.05.001</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2009-08, Vol.47 (8), p.1903-1908 |
| issn | 0278-6915 1873-6351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_34608144 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | animal models Animals Antioxidants - pharmacology ascorbic acid Ascorbic Acid - pharmacology Biological and medical sciences edema Epididymis - drug effects Epididymis - pathology Follicle Stimulating Hormone - blood follicle-stimulating hormone Histopathology human health Insecticides - antagonists & inhibitors Insecticides - toxicity interstitial tissues luteinizing hormone Luteinizing Hormone - blood Malathion Malathion - antagonists & inhibitors Malathion - toxicity Male Medical sciences necrosis Organophosphate insecticide Pesticides, fertilizers and other agrochemicals toxicology protective effect Rats seminiferous tubules Sperm Count sperm motility Sperm Motility - drug effects spermatozoa Spermatozoa - drug effects Spermatozoa - ultrastructure synergism testes Testicular Diseases - chemically induced Testicular Diseases - pathology Testicular toxicity Testis - pathology testosterone Testosterone - blood toxicity Toxicology Vitamin C Vitamin E Vitamin E - pharmacology vitamin supplements xenobiotics |
| title | Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E |
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