Using Bode Plots to Access Intracellular Coupling
This paper describes the development of a simple model of a human B cell in suspension to predict the coupling frequency of a time varying external electric field to the nucleoplasm while minimizing any significant effects on the plasma membrane and nuclear envelope. The approach is based on the mea...
Gespeichert in:
Veröffentlicht in: | IEEE transactions on plasma science 2008-08, Vol.36 (4), p.1659-1664 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1664 |
---|---|
container_issue | 4 |
container_start_page | 1659 |
container_title | IEEE transactions on plasma science |
container_volume | 36 |
creator | Gerber, H.L. Joshi, R.P. Tseng, C.C. |
description | This paper describes the development of a simple model of a human B cell in suspension to predict the coupling frequency of a time varying external electric field to the nucleoplasm while minimizing any significant effects on the plasma membrane and nuclear envelope. The approach is based on the measured parameters for two-shelled model in the literature. The two-shelled model solves the Laplace's equation and assumes continuity of complex current and potential at each interface. The model is first solved using the symbolic feature in MATLAB. Using the complex current continuity boundary condition, we determine a simplified series equivalent circuit that is applicable to a specific frequency range, where most of the absorbed power in the cell occurs in the nucleoplasm. A smaller portion of the absorbed power occurs in the cytoplasm. The modeling also provides predictions of the operating frequency range for maximally selective energy targeting at the nucleoplasm. |
doi_str_mv | 10.1109/TPS.2008.2001042 |
format | Article |
fullrecord | <record><control><sourceid>proquest_RIE</sourceid><recordid>TN_cdi_proquest_miscellaneous_34525469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ieee_id>4599009</ieee_id><sourcerecordid>1546343411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-3b23ec136da32050df7390f3f8cc86eb5e25c2205202fd402500a2512c2fd7123</originalsourceid><addsrcrecordid>eNp9kE1PwzAMQCMEEmNwR-JScYBThxPXa3McEx-TJjGJ7RxlaYo6dc1I2gP_nlRDHDhwsWX52bIfY9ccJpyDfFiv3icCoBgCh0ycsBGXKFOJOZ2yEYDEFAuO5-wihF1kMgIxYnwT6vYjeXSlTVaN60LSuWRmjA0hWbSd18Y2Td9on8xdf2gie8nOKt0Ee_WTx2zz_LSev6bLt5fFfLZMDRJ2KW4FWsNxWmoUQFBWOUqosCqMKaZ2S1aQEbEjQFRlBoIAtCAuTCxzLnDM7o97D9599jZ0al-H4RrdWtcHVeQEhMgxknf_kpiRoGwqI3j7B9y53rfxC8Ul8Tz6ogjBETLeheBtpQ6-3mv_pTioQbWKqtWgWv2ojiM3x5HaWvuLZyTloP0b9WJ24g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195179395</pqid></control><display><type>article</type><title>Using Bode Plots to Access Intracellular Coupling</title><source>IEEE Electronic Library (IEL)</source><creator>Gerber, H.L. ; Joshi, R.P. ; Tseng, C.C.</creator><creatorcontrib>Gerber, H.L. ; Joshi, R.P. ; Tseng, C.C.</creatorcontrib><description>This paper describes the development of a simple model of a human B cell in suspension to predict the coupling frequency of a time varying external electric field to the nucleoplasm while minimizing any significant effects on the plasma membrane and nuclear envelope. The approach is based on the measured parameters for two-shelled model in the literature. The two-shelled model solves the Laplace's equation and assumes continuity of complex current and potential at each interface. The model is first solved using the symbolic feature in MATLAB. Using the complex current continuity boundary condition, we determine a simplified series equivalent circuit that is applicable to a specific frequency range, where most of the absorbed power in the cell occurs in the nucleoplasm. A smaller portion of the absorbed power occurs in the cytoplasm. The modeling also provides predictions of the operating frequency range for maximally selective energy targeting at the nucleoplasm.</description><identifier>ISSN: 0093-3813</identifier><identifier>EISSN: 1939-9375</identifier><identifier>DOI: 10.1109/TPS.2008.2001042</identifier><identifier>CODEN: ITPSBD</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Biological cell modeling ; Biomembranes ; Boundary conditions ; cell nucleoplasm frequency absorption ; Cells ; Continuity ; Electric fields ; Electric potential ; Equivalent circuits ; Frequencies ; Frequency ; Frequency ranges ; Humans ; Joining ; Laplace equation ; Laplace equations ; Mathematical model ; Mathematical models ; MATLAB ; Membranes ; Nuclear power generation ; Plasma ; Plasma measurements ; Predictive models ; two-shell cell equivalent circuit ; two-shell intracellular coupling</subject><ispartof>IEEE transactions on plasma science, 2008-08, Vol.36 (4), p.1659-1664</ispartof><rights>Copyright Institute of Electrical and Electronics Engineers, Inc. (IEEE) Aug 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-3b23ec136da32050df7390f3f8cc86eb5e25c2205202fd402500a2512c2fd7123</citedby><cites>FETCH-LOGICAL-c353t-3b23ec136da32050df7390f3f8cc86eb5e25c2205202fd402500a2512c2fd7123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/4599009$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,780,784,796,27924,27925,54758</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/4599009$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Gerber, H.L.</creatorcontrib><creatorcontrib>Joshi, R.P.</creatorcontrib><creatorcontrib>Tseng, C.C.</creatorcontrib><title>Using Bode Plots to Access Intracellular Coupling</title><title>IEEE transactions on plasma science</title><addtitle>TPS</addtitle><description>This paper describes the development of a simple model of a human B cell in suspension to predict the coupling frequency of a time varying external electric field to the nucleoplasm while minimizing any significant effects on the plasma membrane and nuclear envelope. The approach is based on the measured parameters for two-shelled model in the literature. The two-shelled model solves the Laplace's equation and assumes continuity of complex current and potential at each interface. The model is first solved using the symbolic feature in MATLAB. Using the complex current continuity boundary condition, we determine a simplified series equivalent circuit that is applicable to a specific frequency range, where most of the absorbed power in the cell occurs in the nucleoplasm. A smaller portion of the absorbed power occurs in the cytoplasm. The modeling also provides predictions of the operating frequency range for maximally selective energy targeting at the nucleoplasm.</description><subject>Biological cell modeling</subject><subject>Biomembranes</subject><subject>Boundary conditions</subject><subject>cell nucleoplasm frequency absorption</subject><subject>Cells</subject><subject>Continuity</subject><subject>Electric fields</subject><subject>Electric potential</subject><subject>Equivalent circuits</subject><subject>Frequencies</subject><subject>Frequency</subject><subject>Frequency ranges</subject><subject>Humans</subject><subject>Joining</subject><subject>Laplace equation</subject><subject>Laplace equations</subject><subject>Mathematical model</subject><subject>Mathematical models</subject><subject>MATLAB</subject><subject>Membranes</subject><subject>Nuclear power generation</subject><subject>Plasma</subject><subject>Plasma measurements</subject><subject>Predictive models</subject><subject>two-shell cell equivalent circuit</subject><subject>two-shell intracellular coupling</subject><issn>0093-3813</issn><issn>1939-9375</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNp9kE1PwzAMQCMEEmNwR-JScYBThxPXa3McEx-TJjGJ7RxlaYo6dc1I2gP_nlRDHDhwsWX52bIfY9ccJpyDfFiv3icCoBgCh0ycsBGXKFOJOZ2yEYDEFAuO5-wihF1kMgIxYnwT6vYjeXSlTVaN60LSuWRmjA0hWbSd18Y2Td9on8xdf2gie8nOKt0Ee_WTx2zz_LSev6bLt5fFfLZMDRJ2KW4FWsNxWmoUQFBWOUqosCqMKaZ2S1aQEbEjQFRlBoIAtCAuTCxzLnDM7o97D9599jZ0al-H4RrdWtcHVeQEhMgxknf_kpiRoGwqI3j7B9y53rfxC8Ul8Tz6ogjBETLeheBtpQ6-3mv_pTioQbWKqtWgWv2ojiM3x5HaWvuLZyTloP0b9WJ24g</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Gerber, H.L.</creator><creator>Joshi, R.P.</creator><creator>Tseng, C.C.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>20080801</creationdate><title>Using Bode Plots to Access Intracellular Coupling</title><author>Gerber, H.L. ; Joshi, R.P. ; Tseng, C.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-3b23ec136da32050df7390f3f8cc86eb5e25c2205202fd402500a2512c2fd7123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological cell modeling</topic><topic>Biomembranes</topic><topic>Boundary conditions</topic><topic>cell nucleoplasm frequency absorption</topic><topic>Cells</topic><topic>Continuity</topic><topic>Electric fields</topic><topic>Electric potential</topic><topic>Equivalent circuits</topic><topic>Frequencies</topic><topic>Frequency</topic><topic>Frequency ranges</topic><topic>Humans</topic><topic>Joining</topic><topic>Laplace equation</topic><topic>Laplace equations</topic><topic>Mathematical model</topic><topic>Mathematical models</topic><topic>MATLAB</topic><topic>Membranes</topic><topic>Nuclear power generation</topic><topic>Plasma</topic><topic>Plasma measurements</topic><topic>Predictive models</topic><topic>two-shell cell equivalent circuit</topic><topic>two-shell intracellular coupling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerber, H.L.</creatorcontrib><creatorcontrib>Joshi, R.P.</creatorcontrib><creatorcontrib>Tseng, C.C.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>IEEE transactions on plasma science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Gerber, H.L.</au><au>Joshi, R.P.</au><au>Tseng, C.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using Bode Plots to Access Intracellular Coupling</atitle><jtitle>IEEE transactions on plasma science</jtitle><stitle>TPS</stitle><date>2008-08-01</date><risdate>2008</risdate><volume>36</volume><issue>4</issue><spage>1659</spage><epage>1664</epage><pages>1659-1664</pages><issn>0093-3813</issn><eissn>1939-9375</eissn><coden>ITPSBD</coden><abstract>This paper describes the development of a simple model of a human B cell in suspension to predict the coupling frequency of a time varying external electric field to the nucleoplasm while minimizing any significant effects on the plasma membrane and nuclear envelope. The approach is based on the measured parameters for two-shelled model in the literature. The two-shelled model solves the Laplace's equation and assumes continuity of complex current and potential at each interface. The model is first solved using the symbolic feature in MATLAB. Using the complex current continuity boundary condition, we determine a simplified series equivalent circuit that is applicable to a specific frequency range, where most of the absorbed power in the cell occurs in the nucleoplasm. A smaller portion of the absorbed power occurs in the cytoplasm. The modeling also provides predictions of the operating frequency range for maximally selective energy targeting at the nucleoplasm.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/TPS.2008.2001042</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | ISSN: 0093-3813 |
ispartof | IEEE transactions on plasma science, 2008-08, Vol.36 (4), p.1659-1664 |
issn | 0093-3813 1939-9375 |
language | eng |
recordid | cdi_proquest_miscellaneous_34525469 |
source | IEEE Electronic Library (IEL) |
subjects | Biological cell modeling Biomembranes Boundary conditions cell nucleoplasm frequency absorption Cells Continuity Electric fields Electric potential Equivalent circuits Frequencies Frequency Frequency ranges Humans Joining Laplace equation Laplace equations Mathematical model Mathematical models MATLAB Membranes Nuclear power generation Plasma Plasma measurements Predictive models two-shell cell equivalent circuit two-shell intracellular coupling |
title | Using Bode Plots to Access Intracellular Coupling |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T02%3A40%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_RIE&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Using%20Bode%20Plots%20to%20Access%20Intracellular%20Coupling&rft.jtitle=IEEE%20transactions%20on%20plasma%20science&rft.au=Gerber,%20H.L.&rft.date=2008-08-01&rft.volume=36&rft.issue=4&rft.spage=1659&rft.epage=1664&rft.pages=1659-1664&rft.issn=0093-3813&rft.eissn=1939-9375&rft.coden=ITPSBD&rft_id=info:doi/10.1109/TPS.2008.2001042&rft_dat=%3Cproquest_RIE%3E1546343411%3C/proquest_RIE%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=195179395&rft_id=info:pmid/&rft_ieee_id=4599009&rfr_iscdi=true |