Genotoxic and carcinogenic effects of antipsychotics and antidepressants

Abstract This review provides a compendium of the results of genotoxicity and carcinogenicity assays performed on marketed antipsychotics and antidepressants. Of the 104 drugs examined, 47 (45.2%) do not have retrievable data. The remaining 57 (54.8%) have at least one and often more than one genoto...

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Veröffentlicht in:	Toxicology (Amsterdam) 2009-07, Vol.261 (3), p.77-88
Hauptverfasser:	Brambilla, Giovanni, Mattioli, Francesca, Martelli, Antonietta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - toxicity Antipsychotic Agents - toxicity Antipsychotics and antidepressants Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Carcinogenicity Tests Cell Transformation, Neoplastic - drug effects Chemical agents Chromosome Aberrations - chemically induced Consumer Product Safety Emergency Genotoxicity Humans Medical sciences Mutagenicity Tests Neoplasms - chemically induced Risk Assessment Toxicology Tumors
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