Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins ( Carassius auratus)
Nonylphenol, an estrogenic-like compound, can induce vitellogenin synthesis in males and immature Teleostean species, but little is known about its effects on thyroid hormones balance. The present study evaluated the potential effects of a single acute exposure to nonylphenol (i.p. injected) on the...
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| Veröffentlicht in: | The Science of the total environment 2009-05, Vol.407 (10), p.3301-3306 |
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| creator | Zaccaroni, A. Gamberoni, M. Mandrioli, L. Sirri, R. Mordenti, O. Scaravelli, D. Sarli, G. Parmeggiani, A. |
| description | Nonylphenol, an estrogenic-like compound, can induce vitellogenin synthesis in males and immature Teleostean species, but little is known about its effects on thyroid hormones balance. The present study evaluated the potential effects of a single acute exposure to nonylphenol (i.p. injected) on the thyroid and reproductive axis of 250 shubunkins (
Carassius auratus). Plasma levels of thyroid hormones were quantified immunoenzymatically by ELISA assay. Nonylphenol induced a significant decrease of thyroxin levels, whereas no effect on triiodothyronine concentrations was detected. No histopathological changes were detected in thyroid or testes. The toxicological data confirmed that nonylphenol exerts an estrogenic effect on male fish. In addition, nonylphenol was suspected to inhibit the thyroid hormones balance, suggesting the thyroid should be included among the other endocrine glands susceptible to endocrine disruption. |
| doi_str_mv | 10.1016/j.scitotenv.2009.01.036 |
| format | Article |
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Carassius auratus). Plasma levels of thyroid hormones were quantified immunoenzymatically by ELISA assay. Nonylphenol induced a significant decrease of thyroxin levels, whereas no effect on triiodothyronine concentrations was detected. No histopathological changes were detected in thyroid or testes. The toxicological data confirmed that nonylphenol exerts an estrogenic effect on male fish. In addition, nonylphenol was suspected to inhibit the thyroid hormones balance, suggesting the thyroid should be included among the other endocrine glands susceptible to endocrine disruption.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2009.01.036</identifier><identifier>PMID: 19232673</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Biomarkers - blood ; Carassius auratus ; Ecotoxicology, biological effects of pollution ; Endocrine Disruptors - toxicity ; Freshwater ; Fundamental and applied biological sciences. Psychology ; General aspects ; Goldfish ; Hepatocytes - drug effects ; Hepatocytes - metabolism ; Hepatocytes - pathology ; Histology ; Liver - drug effects ; Liver - pathology ; Longevity - drug effects ; Male ; Nonylphenol ; Phenols - toxicity ; Techniques ; Testis - drug effects ; Testis - metabolism ; Testis - pathology ; Thyroid Gland - drug effects ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroid hormones ; Thyroid Hormones - blood ; Toxicity Tests ; Vitellogenin ; Water Pollutants, Chemical - toxicity</subject><ispartof>The Science of the total environment, 2009-05, Vol.407 (10), p.3301-3306</ispartof><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-cb5649e40eabd950c76be5c86f4404ebbfcdb3b1ef7970b57246dea1fc0fa2883</citedby><cites>FETCH-LOGICAL-c485t-cb5649e40eabd950c76be5c86f4404ebbfcdb3b1ef7970b57246dea1fc0fa2883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0048969709000758$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21399109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19232673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaccaroni, A.</creatorcontrib><creatorcontrib>Gamberoni, M.</creatorcontrib><creatorcontrib>Mandrioli, L.</creatorcontrib><creatorcontrib>Sirri, R.</creatorcontrib><creatorcontrib>Mordenti, O.</creatorcontrib><creatorcontrib>Scaravelli, D.</creatorcontrib><creatorcontrib>Sarli, G.</creatorcontrib><creatorcontrib>Parmeggiani, A.</creatorcontrib><title>Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins ( Carassius auratus)</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Nonylphenol, an estrogenic-like compound, can induce vitellogenin synthesis in males and immature Teleostean species, but little is known about its effects on thyroid hormones balance. The present study evaluated the potential effects of a single acute exposure to nonylphenol (i.p. injected) on the thyroid and reproductive axis of 250 shubunkins (
Carassius auratus). Plasma levels of thyroid hormones were quantified immunoenzymatically by ELISA assay. Nonylphenol induced a significant decrease of thyroxin levels, whereas no effect on triiodothyronine concentrations was detected. No histopathological changes were detected in thyroid or testes. The toxicological data confirmed that nonylphenol exerts an estrogenic effect on male fish. In addition, nonylphenol was suspected to inhibit the thyroid hormones balance, suggesting the thyroid should be included among the other endocrine glands susceptible to endocrine disruption.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Carassius auratus</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Goldfish</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - metabolism</subject><subject>Hepatocytes - pathology</subject><subject>Histology</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Longevity - drug effects</subject><subject>Male</subject><subject>Nonylphenol</subject><subject>Phenols - toxicity</subject><subject>Techniques</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid hormones</subject><subject>Thyroid Hormones - blood</subject><subject>Toxicity Tests</subject><subject>Vitellogenin</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEokvhL1BfQHBI8Ffi-Fit-JIqcaA9W7YzYb117MVOKpZfj6NdlWMtS7488854nqq6IrghmHSf9k22bo4zhIeGYiwbTBrMumfVhvRC1gTT7nm1wZj3teykuKhe5bzH5YievKwuiKSMdoJtqr-3u2OKbkC7mKYYICNdLjqs0bPTHoFO_oiMi5NO95BQHBH8OcS8JEBzRLwOMRz9YQcheuQC0sPiZzRpDyjvFrOEexcy-oC2Oumc3VLSl6TnJX98Xb0Ytc_w5vxeVndfPt9uv9U3P75-317f1Jb37Vxb03ZcAsegzSBbbEVnoLV9N3KOORgz2sEwQ2AUUmDTCsq7ATQZLR417Xt2Wb0_5R5S_L1AntXksgXvdYC4ZMU463vaPQ1SzAUjlBVQnECbYs4JRnVIruznqAhWqx-1V49-1OpHYaKKn1L59txiMRMM_-vOQgrw7gzobLUfkw7W5UeOEiYlwbJwVydu1FHpX6kwdz8pJqx0J4yK9TfXJwLKbh8cpHUkCBYGl8DOaojuyXH_AaMhvtc</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Zaccaroni, A.</creator><creator>Gamberoni, M.</creator><creator>Mandrioli, L.</creator><creator>Sirri, R.</creator><creator>Mordenti, O.</creator><creator>Scaravelli, D.</creator><creator>Sarli, G.</creator><creator>Parmeggiani, A.</creator><general>Elsevier B.V</general><general>[Amsterdam; New York]: Elsevier Science</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20090501</creationdate><title>Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins ( Carassius auratus)</title><author>Zaccaroni, A. ; Gamberoni, M. ; Mandrioli, L. ; Sirri, R. ; Mordenti, O. ; Scaravelli, D. ; Sarli, G. ; Parmeggiani, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-cb5649e40eabd950c76be5c86f4404ebbfcdb3b1ef7970b57246dea1fc0fa2883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Carassius auratus</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Goldfish</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - metabolism</topic><topic>Hepatocytes - pathology</topic><topic>Histology</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Longevity - drug effects</topic><topic>Male</topic><topic>Nonylphenol</topic><topic>Phenols - toxicity</topic><topic>Techniques</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid hormones</topic><topic>Thyroid Hormones - blood</topic><topic>Toxicity Tests</topic><topic>Vitellogenin</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaccaroni, A.</creatorcontrib><creatorcontrib>Gamberoni, M.</creatorcontrib><creatorcontrib>Mandrioli, L.</creatorcontrib><creatorcontrib>Sirri, R.</creatorcontrib><creatorcontrib>Mordenti, O.</creatorcontrib><creatorcontrib>Scaravelli, D.</creatorcontrib><creatorcontrib>Sarli, G.</creatorcontrib><creatorcontrib>Parmeggiani, A.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaccaroni, A.</au><au>Gamberoni, M.</au><au>Mandrioli, L.</au><au>Sirri, R.</au><au>Mordenti, O.</au><au>Scaravelli, D.</au><au>Sarli, G.</au><au>Parmeggiani, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins ( Carassius auratus)</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>407</volume><issue>10</issue><spage>3301</spage><epage>3306</epage><pages>3301-3306</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><coden>STENDL</coden><abstract>Nonylphenol, an estrogenic-like compound, can induce vitellogenin synthesis in males and immature Teleostean species, but little is known about its effects on thyroid hormones balance. The present study evaluated the potential effects of a single acute exposure to nonylphenol (i.p. injected) on the thyroid and reproductive axis of 250 shubunkins (
Carassius auratus). Plasma levels of thyroid hormones were quantified immunoenzymatically by ELISA assay. Nonylphenol induced a significant decrease of thyroxin levels, whereas no effect on triiodothyronine concentrations was detected. No histopathological changes were detected in thyroid or testes. The toxicological data confirmed that nonylphenol exerts an estrogenic effect on male fish. In addition, nonylphenol was suspected to inhibit the thyroid hormones balance, suggesting the thyroid should be included among the other endocrine glands susceptible to endocrine disruption.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>19232673</pmid><doi>10.1016/j.scitotenv.2009.01.036</doi><tpages>6</tpages></addata></record> |
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| subjects | Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Biomarkers - blood Carassius auratus Ecotoxicology, biological effects of pollution Endocrine Disruptors - toxicity Freshwater Fundamental and applied biological sciences. Psychology General aspects Goldfish Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Histology Liver - drug effects Liver - pathology Longevity - drug effects Male Nonylphenol Phenols - toxicity Techniques Testis - drug effects Testis - metabolism Testis - pathology Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid hormones Thyroid Hormones - blood Toxicity Tests Vitellogenin Water Pollutants, Chemical - toxicity |
| title | Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins ( Carassius auratus) |
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